Glucose-derived spiro-isoxazolines are anti-hyperglycemic agents against type 2 diabetes through glycogen phosphorylase inhibition [PDF]
, 2016 International audienceGlycogen phosphorylase (GP) is a target for the treatment of hyperglycaemia in the context of type 2 diabetes. This enzyme is responsible for the depolymerization of glycogen into glucose thereby affecting the levels of glucose in ...
Azay-Milhau, Jacqueline +16 more
core +2 more sources
Chalcones as versatile synthons for the synthesis of 5- and 6-membered nitrogen heterocylces [PDF]
, 2014 Chalcones belong to the flavonoid family which constitutes one of the major classes of naturally occurring oxygen heterocyclic compounds. The alpha,beta-unsaturated carbonyl system of chalcones possesses two electrophilic reactive centers allowing them ...
Albuquerque, Hélio +3 more
core +1 more source
Bicyclic Isoxazoline Derivatives: Synthesis and Evaluation of Biological Activity
Molecules, 2022 The application of non-planar scaffolds in drug design allows for the enlargement of the chemical space, and for the construction of molecules that have more effective target–ligand interactions or are less prone to the development of resistance.
Kseniya N. Sedenkova +11 more
doaj +1 more source
Journal of Organic Chemistry, 2020 A facile oxidative heterocyclization of commercially available amines and tert-butyl nitrite with alkynes or alkenes leading to isoxazoles or isoxazolines is described.
Xiao-Wei Zhang +4 more
semanticscholar +1 more source
Anti-cancer activity of novel dibenzo[b,f]azepine tethered isoxazoline derivatives [PDF]
, 2012 10.1186/1472-6769-12-5BMC Chemical ...
Anilkumar, N.C. +10 more
core +3 more sources
A one-pot synthesis of 3-trifluoromethyl-2-isoxazolines from trifluoromethyl aldoxime
Beilstein Journal of Organic Chemistry, 2013 Functionalized 3-trifluoromethyl-2-isoxazolines and 3-trifluoromethylisoxazoles were easily prepared from trifluoromethyl aldoxime 2 under mild conditions by using DIB as oxidant.
Raoni S. B. Gonçalves +4 more
doaj +1 more source
1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones [PDF]
, 2010 1,3-Dipolar cycloadditions of 2-thio-3-chloroacrylamides with nitrile oxides and nitrones is described. A series of novel isoxazolines are isolated from the nitrile oxide cycloadditions, whilst the isoxazolines generated from the nitrone cycloadditions ...
Kissane, Marie +2 more
core +1 more source
A comparative laboratory trial evaluating the immediate efficacy of fluralaner, afoxolaner, sarolaner and imidacloprid + permethrin against adult Rhipicephalus sanguineus (sensu lato) ticks attached to dogs [PDF]
, 2012 Variational methods are used for targeting specific correlation effects by tailoring the configuration space. Independent sets of correlation orbitals, embedded in partitioned correlation functions (PCFs), are produced from multiconfiguration Hartree-
Froese Fischer, Charlotte +5 more
core +1 more source
PLoS Pathogens, 2021 Control of infestation by cosmopolitan lice (Pediculus humanus) is increasingly difficult due to the transmission of parasites resistant to pediculicides.
Nicolas Lamassiaude +7 more
doaj +1 more source
An anomalous hydration/dehydration sequence for the mild generation of a nitrile oxide [PDF]
, 2011 A nitrile oxide containing a carbamoyl group is readily generated upon the treatment of 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with water under mild reaction conditions, even in the absence of special reagents.
884 +19 more
core +2 more sources