Results 71 to 80 of about 8,819 (284)

Antimicrobial use guidelines for canine pyoderma by the International Society for Companion Animal Infectious Diseases (ISCAID)

open access: yesVeterinary Dermatology, Volume 36, Issue 3, Page 234-282, June 2025.
Background – Canine pyoderma is one of the most common presentations in small animal practice, frequently leading to antimicrobial prescribing. Objectives – To provide clinicians with antimicrobial treatment guidelines for staphylococcal pyoderma, including those involving meticillin‐resistant staphylococci.
Anette Loeffler   +9 more
wiley   +1 more source

Cyclodextrin-based catalysts and molecular reactors [PDF]

open access: yes, 2015
We suggest two nonparametric approaches, based on kernel methods and orthogonal series to estimating regression functions in the presence of instrumental variables. For the first time in this class of problems, we derive optimal convergence rates, and
Easton, Christopher J.
core   +1 more source

Synthesis of highly functionalized β-aminocyclopentanecarboxylate stereoisomers by reductive ring opening reaction of isoxazolines

open access: yesBeilstein Journal of Organic Chemistry, 2012
A rapid and simple procedure was devised for the synthesis of multifunctionalized cyclic β-amino esters and γ-amino alcohols via the 1,3-dipolar cycloaddition of nitrile oxides to β-aminocyclopentenecarboxylates.
Melinda Nonn   +3 more
doaj   +1 more source

Cu-Catalyzed Oxyalkynylation and Aminoalkynylation of Unactivated Alkenes: Synthesis of Alkynyl-Featured Isoxazolines and Cyclic Nitrones.

open access: yesOrganic Letters, 2018
A convenient and efficient vicinal oxyalkynylation/aminoalkynylation of internal unactivated alkenes is achieved by means of a Cu-catalyzed radical cascade reaction of unsaturated ketoximes with ethynylbenziodoxolone (EBX) reagents. This protocol enables
Wen-Jun Han   +5 more
semanticscholar   +1 more source

A Facile Synthesis of 3‐Substituted Coumarins and Investigation of Their 3CLpro Inhibition Activity Against SARS‐CoV‐2

open access: yesChemistryOpen, Volume 14, Issue 5, May 2025.
A user‐friendly protocol for the synthesis 3‐substituted coumarin derivatives was developed using Friedel‐Crafts alkylation and ozonolysis as key steps. Deactivation of 3‐chymotrypsin like protease (3CLpro) enzyme using these coumarin derivatives were investigated to explored their potential as 3CLpro inhibitors for Covid‐19 Therapeutics.
Manoj K. Choudhary   +5 more
wiley   +1 more source

Steroid [16, 17-c]isoxazoline

open access: yesChemical and Pharmaceutical Bulletin, 1964
5'-Methyl-5α-androstano[16, 17-c]isoxazolin-3β-ol (Va) and 5'-methylandrost-5-eno[16, 17-c]isoxazolin-3β-ol (Vb), were obtained by treatment of 3β, 20α-dihydroxy-5α-pregnan-16-one 3-acetate 16-oxime (IIIa) or 3β, 20α-dihydroxypregn-5-en-16-one 3-acetate 16-oxime (IIIb) with tosyl chloride in pyridine followed by alkaline hydrolysis. Oxidation of Va and
Katsura Morita   +2 more
openaire   +4 more sources

The Isoxazoline Route to α-Methylen Lactones. [PDF]

open access: yesTetrahedron Letters, 1983
A new route to α-methylene lactones, important structural subunits of many natural products, has been developed using the nitrile oxide derived from 2-nitroethanol.
Arun K. Ghosh, Alan P. Kozikowski
openaire   +3 more sources

The catalytic hydrogenation of 3-(2-fluorophenyl)- and 3-(4-fluorophenyl)-4,4-ethylenedioxycyclopenta[d]isoxazolines [PDF]

open access: yes, 2016
The catalytic hydrogenation of 3-(2-fluorophenyl)- and 3-(4-fluorophenyl)-4,4-ethylenedioxycyclo-penta[d ]isoxazolines led with good yields to corresponding fluorinated β -hydroxyketones.
Antonevich, I. P.   +2 more
core  

Inverse electron-demand 1,3-dipolar cycloaddition of nitrile oxide with common nitriles leading to 3-functionalized 1,2,4-oxadiazoles [PDF]

open access: yes, 2011
A carbamoyl-substituted nitrile oxide was generated upon treatment of easily available 2-methyl-4-nitro-3-isoxazolin-5(2H)-one with THF (not dried); the reaction proceeded efficiently even in the absence of any special reagents and reaction conditions ...
1020   +15 more
core   +1 more source

Synthesis and biological profile of substituted hexahydrofuro[3,4‐b]furans, a novel class of bicyclic acyl‐acyl carrier protein (ACP) thioesterase inhibitors

open access: yesPest Management Science, Volume 81, Issue 5, Page 2635-2651, May 2025.
The present work covers a series of novel herbicidal lead structures that possess a hexahydrofuro[3,4‐b]furan scaffold as a structural key feature, carrying ortho‐substituted aryloxy side chains. Based on an optimized synthetic approach a broader structure–activity relationship (SAR) study was carried out delivering some lead structures that show good ...
Hartmut Ahrens   +13 more
wiley   +1 more source

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