Results 71 to 80 of about 8,940 (287)

Effect of a Spray Containing Occlusive Agents, Humectants and Physiological Lipids on Skin Hydration of Healthy Dogs When Applied After Bathing With a Chlorhexidine 2%/Miconazole 2% Shampoo

open access: yesVeterinary Dermatology, EarlyView.
Background: Normal hydration of the canine epidermis is imperative for cutaneous homeostasis. Xerosis may be encountered in canine atopic dermatitis and may be aggravated by topical antiseptics. Hypothesis and Objectives: To evaluate the hydrating properties and the safety of a spray (Sensiderm spray; MP Labo) when applied after shampooing healthy dogs
Adamantia Pseftogka   +3 more
wiley   +1 more source

Steroid [16, 17-c]isoxazoline

open access: yesChemical and Pharmaceutical Bulletin, 1964
5'-Methyl-5α-androstano[16, 17-c]isoxazolin-3β-ol (Va) and 5'-methylandrost-5-eno[16, 17-c]isoxazolin-3β-ol (Vb), were obtained by treatment of 3β, 20α-dihydroxy-5α-pregnan-16-one 3-acetate 16-oxime (IIIa) or 3β, 20α-dihydroxypregn-5-en-16-one 3-acetate 16-oxime (IIIb) with tosyl chloride in pyridine followed by alkaline hydrolysis. Oxidation of Va and
Katsura Morita   +2 more
openaire   +4 more sources

Mechanochemische Methoden mit Anwendung in der Late‐Stage Modifizierung Pharmazeutisch Wirksamer Verbindungen

open access: yesAngewandte Chemie, Volume 137, Issue 41, October 6, 2025.
Dieser Review diskutiert mechanochemische Strategien zur späten Modifizierung bioaktiver Wirkstoffe und bietet zugleich eine wertvolle Übersicht zur Auswahl geeigneter Substrate, um das pharmazeutische Potenzial neuer und bestehender (mechano)chemischer Verfahren zu evaluieren.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Cyclodextrin-based catalysts and molecular reactors [PDF]

open access: yes, 2015
We suggest two nonparametric approaches, based on kernel methods and orthogonal series to estimating regression functions in the presence of instrumental variables. For the first time in this class of problems, we derive optimal convergence rates, and
Easton, Christopher J.
core   +1 more source

The Isoxazoline Route to α-Methylen Lactones. [PDF]

open access: yesTetrahedron Letters, 1983
A new route to α-methylene lactones, important structural subunits of many natural products, has been developed using the nitrile oxide derived from 2-nitroethanol.
Arun K. Ghosh, Alan P. Kozikowski
openaire   +3 more sources

Mechanochemical Strategies Applied to the Late‐Stage Modifications of Pharmaceutically Active Compounds

open access: yesAngewandte Chemie International Edition, Volume 64, Issue 41, October 6, 2025.
This review highlights mechanochemical strategies for the late‐stage modification of active pharmaceutical ingredients (APIs), providing a valuable resource for selecting substrates to evaluate the pharmaceutical potential of novel and existing (mechano)chemical protocols.
Johanna Templ, Lars Borchardt
wiley   +1 more source

Synthesis of highly functionalized β-aminocyclopentanecarboxylate stereoisomers by reductive ring opening reaction of isoxazolines

open access: yesBeilstein Journal of Organic Chemistry, 2012
A rapid and simple procedure was devised for the synthesis of multifunctionalized cyclic β-amino esters and γ-amino alcohols via the 1,3-dipolar cycloaddition of nitrile oxides to β-aminocyclopentenecarboxylates.
Melinda Nonn   +3 more
doaj   +1 more source

Synthesis of some flurophenyl 4-oxocyclopentane[d]isoxazolines and their dioxolane derivatives [PDF]

open access: yes, 2013
A number of new fluorophenyl 4-oxocyclopentane[d]isoxazolines and their dioxolane derivatives has been synthesized. The obtained substances are of the interest as the perspective biologically active compounds as well as the intermediates in total ...
Antonevich, I. P., Nesterova, S. V.
core  

Assessing the in Planta Efficacy of Oxathiapiprolin as a Potential Treatment for Kauri Dieback Disease

open access: yesMicrobiologyOpen, Volume 14, Issue 5, October 2025.
We tested the oomycide oxathiapiprolin as a protective and curative agent against kauri dieback disease (caused by Phytophthora agathidicida) in Agathis australis seedlings. Protective application of oxathiapiprolin (10 or 50 mg per seedling) effectively prevented disease, but it did not cure existing infections.
Hannah F. Robinson   +2 more
wiley   +1 more source

Nitroimidazoles XIII. Synthesis of Substituted (1-Methyl-5-Nitro-2-Imidazolyl) Isoxazoles [PDF]

open access: yesIranian Journal of Chemistry & Chemical Engineering, 1998
The beta0diketone derivatives of nitroimidazole were synthesized from the reaction of magnesium salt of beta-ketoaccids 3 with imidazolide 4. The raction of beta-diketones with hydroxylamine hydrochloride afforded either the isoxazoles or the 5-hydroxyl ...
Abbas Shafiee, Mohammad ALi Ebrahimzadeh
doaj  

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