Results 71 to 80 of about 1,834 (212)

Efficacy of Der f 2/Zen 1‐LAMP1 Plasmid‐Based Vaccine Immunotherapy in Dogs With Atopic Dermatitis: A Proof‐of‐Concept Study

Veterinary Dermatology, Volume 37, Issue 2, Page 306-318, April 2026.
Background: DNA‐based vaccination rapidly induces strong cellular and humoral immune responses, which may be enhanced by inclusion of lysosomal‐associated membrane protein‐1 (LAMP). Objectives: This proof‐of‐concept study evaluated the efficacy and safety of a Der f 2/Zen 1‐LAMP‐based DNA vaccine immunotherapy in client‐owned dogs with nonseasonal AD ...
Petra Bizikova, Chigusa Matsumoto, Shoji Ogino, Toshihiro Tsukui, Kim Love, Marcy Murphy, Ina Herrmann   +6 more
wiley   +1 more source

Synthesis of new coumarin tethered isoxazolines as potential anticancer agents

, 2018
A series of new coumarin tethered isoxazolines (7a-l) were synthesized and evaluated for their cytotoxic potency against human melanoma cancer cell line (UACC 903) as well as fibroblast normal cell line (FF2441). Preliminary results revealed that some of
Kiran, K. R., Jayarama, S., Anil, S. M., Balaji, K. S., Lingaraju, G. S., Sadashiva, M. P.   +5 more
core   +1 more source

Randomised, Double‐Blinded, Placebo‐Controlled Challenge Test With Single Food Items in Dogs With Atopic Dermatitis and Adverse Food Reactions

Veterinary Dermatology, Volume 37, Issue 2, Page 247-256, April 2026.
ABSTRACT Background Identification of offending foods in dogs with adverse food reactions is usually based on “deterioration” during open food challenges. Objectives To examine the placebo effect during double‐blinded, placebo‐controlled food challenges using a predefined set of criteria for relapse.
Evi I. Sofou, Elisa Samuel, Svetlina Aleksandrova, Manolis Chatzis, Manolis N. Saridomichelakis   +4 more
wiley   +1 more source

Dicobalt Octacarbonyl Promoted Rearrangement of 4-Isoxazolines to Acylaziridines:  Dramatic Rate Acceleration with Very High Substrate Tolerance

, 2016
Dicobalt octacarbonyl [Co2(CO)8] in acetonitrile at 75 °C triggers the cleavage of the N−O bond of 4-isoxazolines (1) to bring about the valence rearrangement to 2-acylaziridines (2).
Juri Yoshida (3065511), Teruhiko Ishikawa (2416024), Takayuki Kudoh (171894), Shinobu Manabe (2713375), Ayako Yasuhara (3065508), Seiki Saito (2416018)   +5 more
core   +1 more source

Triplet Energy Transfer‐Driven Intermolecular [2+2] Photocycloaddition of Acyclic Imines and Indoles: Facile Access to Azetidine‐Fused Indolines

Advanced Science, Volume 13, Issue 14, 9 March 2026.
An intermolecular aza‐Paternò‐Büchi reaction of indoles and acyclic imines is enabled by visible‐light‐driven triplet energy transfer, providing azetidine‐fused indolines up to 93% yield for 30 examples and providing a novel protocol to access previously inaccessible scaffolds. ABSTRACT Currently, successful examples of the aza‐[2+2] photocycloaddition
Gang Yang, Zeng Han, Hong Zhang, Xiuling Cui   +3 more
wiley   +1 more source

Mechanistic Insights into the Racemization of Fused Cyclopropyl Isoxazolines

, 2019
Experimental and computational studies of the unexpected racemization of enantiopure fused cyclopropyl isoxazolines are reported. These studies offer insights into the mechanism of racemization, quantify the position of the transition state on the ...
Michael D. Bartberger, Stephen Osgood, Kyle W. Quasdorf, Stephen Osgood (8161803), Seb Caille, Adam B. Birkholz, Michael D. Bartberger (1261599), Kevin Crossley (7495457), John Colyer (2432875), Seb Caille (1633432), John Colyer, Adam B. Birkholz (8161800), Kyle W. Quasdorf (1581082), Kevin Crossley   +13 more
core   +1 more source

Effect of a Spray Containing Occlusive Agents, Humectants and Physiological Lipids on Skin Hydration of Healthy Dogs When Applied After Bathing With a Chlorhexidine 2%/Miconazole 2% Shampoo

Veterinary Dermatology, Volume 37, Issue 1, Page 140-147, February 2026.
Background: Normal hydration of the canine epidermis is imperative for cutaneous homeostasis. Xerosis may be encountered in canine atopic dermatitis and may be aggravated by topical antiseptics. Hypothesis and Objectives: To evaluate the hydrating properties and the safety of a spray (Sensiderm spray; MP Labo) when applied after shampooing healthy dogs
Adamantia Pseftogka, Elisabeta Samuel (Badulescu), Manolis K. Chatzis, Manolis N. Saridomichelakis   +3 more
wiley   +1 more source

Ring cleavage of 3,5-disubstituted 2-isoxazolines by molybdenum hexacarbonyl and water to β-hydroxy ketones.

, 1987
An efficient method for preparing ß-hydroxy ketones from 2-isoxazolines by N-O bond cleavage promoted by molybdenum hexacarbonyl is ...
BENETTI, Simonetta, BARALDI, Pier Giovanni, BARCO, Achille, SIMONI, Daniele, MANFREDINI, Stefano   +4 more
core   +1 more source

Estimated seroprevalence of Ehrlichia canis in dogs in a remote community in the Northern Territory, Australia

Australian Veterinary Journal, Volume 104, Issue 1-2, Page 66-72, January-February 2026.
Background The emergence of Ehrlichia canis in northern Australia in 2020 has reshaped the landscape of tick‐borne diseases in dogs, particularly in rural and remote communities where the brown dog tick (Rhipicephalus linnaei) is endemic. Despite the rapid spread of ehrlichiosis and reported impacts on dog health, its prevalence remains poorly ...
E Shepherdson, K Doust, JH Hoopes, AD Barbosa, J McNeill   +4 more
wiley   +1 more source

Synthesis, Biological Evaluation, and Molecular Docking of Tellurium‐Containing Benzothiazole Derivatives as Enzyme Inhibitors of DNA Gyrase and Dihydrofolate Reductase

BioMed Research International, Volume 2026, Issue 1, 2026.
Tellurium‐containing heterocycles represent an emerging class of organochalcogen compounds with notable redox properties and antimicrobial potential. Incorporation of tellurium into sulfur‐ and nitrogen‐containing frameworks can enhance biological activity through increased polarizability and favorable noncovalent interactions.
Olha Haleha, Valeriy Pantyo, Nataliya Korol, Elvira Danko, Mykhailo Onysko, Poorani Gurumallesh Prabu   +5 more
wiley   +1 more source