Results 51 to 60 of about 218,942 (264)

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Managing Employees’ Employability

, 2021
Abstract This chapter uses research findings and examples from practice to provide a state-of-the-art overview of public sector workers’ employability and its determinants and outcomes. Employability is attracting growing attention from both public and private sector organizations.
Van Harten, J., Vermeeren, Brenda
openaire   +4 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

Research on employee success, performance, and satisfaction in the Bulgarian IT industry

Entrepreneurship and Sustainability Issues
In the heart of Bulgaria’s booming IT industry, a hidden blueprint for success is emerging. Sustaining competitive advantage requires a nuanced understanding of the factors that drive employee performance, satisfaction, and retention.
Ivan Dimitrov, Yoana Krumova, Adile Dimitrova   +2 more
doaj   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

How hybrid work and organisation support shape an IT company’s employee engagement

SA Journal of Human Resource Management
Orientation: Research has yielded conflicting results on the impact of hybrid work and organisational support on work engagement. Some studies show that hybrid work allows flexibility and promotes work–life balance, thereby enhancing engagement, while ...
Warren P. Charles, Aminah Mobara, Tendency Beretu, Lisah Y. Mhembere   +3 more
doaj   +1 more source

High employee involvement and well-being in the IT sector in the Republic of Serbia [PDF]

Ekonomija: teorija i praksa
In the modern business environment, organizations are increasingly focusing on strategies and concepts that help them strengthen their competitive market position. This paper investigates human resource management models, with particular emphasis on high
Jevtić Tamara, Jevtić Jelena, Vidaković Mira   +2 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

How transformational leadership of managers affects employee innovative behavior in IT corporations

Frontiers in Psychology
Organizations are constantly challenged by new technologies that have the potential to transform their business models and organizational identity, and they are working to create an environment that supports innovation. Advances in digital tools for work
Jung Yon Kim, Dong-Yeol Yoon
doaj   +1 more source

Discerning protein pools by selective staining with self‐labeling tags

FEBS Letters, EarlyView.
Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley   +1 more source