Results 131 to 140 of about 6,203 (152)

Itaconate ameliorates cardiovascular inflammation in a mouse model of Kawasaki disease vasculitis - brief report. [PDF]

Front Immunol
Lee Y, Namba T, Atici AE, Aubuchon E, Lane ME, Ross BL, Noval Rivas M, Arditi M.   +7 more
europepmc   +1 more source

Human pneumovirus induces IFN-dependent expression of the immune-responsive gene 1 and is inhibited by 4-octyl itaconate in human macrophages. [PDF]

NAR Mol Med
Spahn AS, Rian K, Gidon A, Louet C, Boyartchuk V, Flo TH, Anthonsen MW.   +6 more
europepmc   +1 more source

Oxalate synthesis pathways that contribute to oxalate accumulation in leaves of bitter dock (<i>Rumex obtusifolius</i> L.) differ between day and night. [PDF]

Plant Biotechnol (Tokyo)
Sakuma W, Murayama H, Miyagi A.
europepmc   +1 more source

Itaconic Acid Directly Binds to the Cysteine Residue of PurF: A Novel Mechanism for Inhibiting Purine Metabolism in Porcine Pathogenic <i>Escherichia coli</i>. [PDF]

Microorganisms
Liu H, Li X, Zhang X, Ge Y, Chen Y, Li X, Wu Z.   +6 more
europepmc   +1 more source

Metabolic control of neuroinflammation: focus on itaconate and its derivatives in CNS disorders. [PDF]

Front Immunol
Wang Y, Liu S, Zhu W, Hao P, Xu J, Mai D, Chen R, Han H, Bian X, Wang B.   +9 more
europepmc   +1 more source

Photocatalytic Annulation of Primary Amines to δ-Lactams: Access to Privileged (Spiro)piperidine Space. [PDF]

Org Lett
Turner-Dore JC, Bell-Tyrer JJ, Askey HE, Richards DL, Polishchuk O, Datsenko OP, Cadge JA, Ciaccia M, Mykhailiuk PK, Cresswell AJ.   +9 more
europepmc   +1 more source

IRG1-itaconate axis in immunometabolism: mechanistic roles and therapeutic potential in inflammatory diseases. [PDF]

Front Immunol
Liu Y, Zhang P, Kong W, Li J, Yang H, Bai H, Fan G, Cao X, Li Y.   +8 more
europepmc   +1 more source

Targeting neuroinflammation: itaconate and mesaconate as therapeutic strategies against H7N7 influenza-associated CNS damage. [PDF]

Front Immunol
Ohm M, He W, Bruder D, Hiller K, Korte M, Hosseini S.   +5 more
europepmc   +1 more source

The Immunomodulatory Metabolite Itaconate Modifies NLRP3 and Inhibits Inflammasome Activation

Cell Metabolism, 2020
The Krebs cycle-derived metabolite itaconate is highly upregulated in inflammatory macrophages and exerts immunomodulatory effects through cysteine modifications on target proteins.
Anne McGettrick, Luke A. J. O'Neill, Alexander Hooftman   +2 more
exaly   +1 more source

Itaconate transporter SLC13A3 impairs tumor immunity via endowing ferroptosis resistance

Cancer Cell
Immune checkpoint blockade (ICB) triggers tumor ferroptosis. However, most patients are unresponsive to ICB. Tumors might evade ferroptosis in the tumor microenvironment (TME).
Weiping Zou, Sara Grove
exaly   +2 more sources