Results 11 to 20 of about 135,785 (350)

Silencing E3 Ubiqutin ligase ITCH as a potential therapy to enhance chemotherapy efficacy in p53 mutant neuroblastoma cells [PDF]

, 2020
P53 mutations are responsible for drug-resistance of tumour cells which impacts on the efficacy of treatment. Alternative tumour suppressor pathways need to be explored to treat p53- deficient tumours.
Hart, Stephen L, Meng, Jinhong, Tagalakis, Aristides D   +2 more
core   +2 more sources

Exploration of sensory and spinal neurons expressing gastrin-releasing peptide in itch and pain related behaviors

Nature Communications, 2020
The role of gastrin related peptide (GRP+) neurons in itch is debated. Here, the authors generate a conditional knock-in mouse to label and manipulate GRP expressing DRG neurons and investigate their role in itch and nociception.
Devin M. Barry, Xue-Ting Liu, Benlong Liu, Xian-Yu Liu, Fang Gao, Xiansi Zeng, Juan Liu, Qianyi Yang, Steven Wilhelm, Jun Yin, Ailin Tao, Zhou-Feng Chen   +11 more
doaj   +1 more source

Current and Emerging Therapies for Chronic Spontaneous Urticaria: A Narrative Review

Dermatology and Therapy, 2023
Chronic spontaneous urticaria (CSU) is a condition in which wheals, angioedema, and pruritus occur spontaneously and recurrently for at least 6 weeks. The etiology of this disease is partially dependent on production of autoantibodies that activate and ...
Gil Yosipovitch, Georgia Biazus Soares, Omar Mahmoud   +2 more
doaj   +1 more source

Role of burn severity and posttraumatic stress symptoms in the co-occurrence of itch and neuropathic pain after burns: A longitudinal study

Frontiers in Medicine, 2022
Itch and pain are common after burns. Neuropathic mechanisms may underlie both modalities but remain not well-understood. This study aims to prospectively document neuropathic pain symptoms and to identify potential itch symptom profiles that differ ...
N. E. E. Van Loey, N. E. E. Van Loey, A. E. E. de Jong, H. W. C. Hofland, A. I. M. van Laarhoven, A. I. M. van Laarhoven   +5 more
doaj   +1 more source

A spinal neural circuitry for converting touch to itch sensation

Nature Communications, 2020
Light touch can sometimes induce unpleasant itch sensation but the neural correlates of this conversion are not well studied. Here, the authors provide evidence that Tac2 expressing spinal interneurons are connected to gastrin-releasing peptide receptor (
Sihan Chen, Xiao-Fei Gao, Yuxi Zhou, Ben-Long Liu, Xian-Yu Liu, Yufen Zhang, Devin M. Barry, Kun Liu, Yingfu Jiao, Rita Bardoni, Weifeng Yu, Zhou-Feng Chen   +11 more
doaj   +1 more source

Predictive factors of quality of life in chronic pruritus patients: A cross-sectional studyCapsule Summary

JAAD International, 2023
Background: Chronic pruritus severely impacts the quality of life (QoL) of patients. Due to its multifactorial nature, the presence of factors that can predict itch-specific QoL needs comprehensive exploration.
Siri Choragudi, BS, Georgia Biazus Soares, BHS, Gil Yosipovitch, MD   +2 more
doaj   +1 more source

Attentional Bias Modification Training for Itch: A Proof-of-Principle Study in Healthy Individuals

Frontiers in Medicine, 2021
Itch draws our attention to allow imposing action against bodily harm (e.g., remove insects). At the same time, itch is found to interfere with ongoing tasks and daily life goals.
Antoinette I. M. van Laarhoven, Antoinette I. M. van Laarhoven, Jennifer M. Becker, Jennifer M. Becker, Dimitri M. L. van Ryckeghem, Dimitri M. L. van Ryckeghem, Dimitri M. L. van Ryckeghem, Stefaan Van Damme, Geert Crombez, Geert Crombez, Reinout W. H. J. Wiers   +10 more
doaj   +1 more source

Mindfulness as Predictor of Itch Catastrophizing in Patients With Atopic Dermatitis: Results of a Cross-Sectional Questionnaire Study

Frontiers in Medicine, 2021
Itch and worry about itch are predominant symptoms in atopic dermatitis (AD). Mindfulness refers to paying attention in a certain way, non-judgementally and on purpose. In patients with chronic pain, which shares several similarities with chronic itch, a
Kjell Lüßmann, Kerry Montgomery, Andrew Thompson, Uwe Gieler, Christoph Zick, Joerg Kupfer, Christina Schut   +6 more
doaj   +1 more source

Brain processing of contagious itch in patients with atopic dermatitis [PDF]

, 2017
Several studies show that itch and scratching cannot only be induced by pruritogens like histamine or cowhage, but also by the presentation of certain (audio-) visual stimuli like pictures on crawling insects or videos showing other people scratching ...
Apkarian, Bae, Buccino, Buccino, Calvo-Merino, Cavanna, Chrostowska-Plak, Evers, Farrow, Fried, Garcia-Larrea, Hanifin, Harsay, Holle, Iacoboni, Ishiuji, Knotkova, Krakauer, Lavery, Lloyd, Mochizuki, Mochizuki, Mochizuki, Mochizuki, Mochizuki, Mochizuki, Niemeier, Palombo, Papoiu, Papoiu, Papoiu, Plassmann, Platek, Savin, Schneider, Schut, Schut, Schut, Schut, Smolke, Ständer, Ständer, Yosipovitch, Yosipovitch, Yosipovitch   +44 more
core   +3 more sources

The prelimbic cortex regulates itch processing by controlling attentional bias

iScience, 2023
Summary: Itch is a complex and unpleasant sensory experience. Recent studies have begun to investigate the neural mechanisms underlying the modulation of sensory and emotional components of itch in the brain.
Guang-Yan Wu, Xiao-Xia Zheng, Shan-Lan Zhao, Yi Wang, Shan Jiang, Yi-Song Wang, Yi-Lun Yi, Juan Yao, Hui-Zhong Wen, Ju Liu, Hong-Li Li, Jian-Feng Sui   +11 more
doaj   +1 more source