Results 11 to 20 of about 77,640 (305)
Molecular Cancer, 2018 Background Circ-ITCH is a circRNA generated from several exons of itchy E3 ubiquitin protein ligase (ITCH) and tumor suppressor served as a sponge for certain miRNAs targeting their parental transcripts of ITCH.
Chengdi Yang +10 more
doaj +2 more sources
S. aureus drives itch and scratch-induced skin damage through a V8 protease-PAR1 axis.
Cell, 2023 Itch is an unpleasant sensation that evokes a desire to scratch. The skin barrier is constantly exposed to microbes and their products. However, the role of microbes in itch generation is unknown.
Liwen Deng +23 more
semanticscholar +1 more source
Journal of Allergy and Clinical Immunology, 2023 Pruritus (or itch) is an unpleasant sensation leading to a desire to scratch. In the epidermis, are selective C or Aδ epidermal nerve endings which are pruriceptors.
L. Miséry +6 more
semanticscholar +1 more source
Nature Communications, 2023 Itch is known to involve the parabrachial nucleus, but the following transmission nodes remain elusive. Here, the authors show in male mice that the central medial thalamic nucleus—medial prefrontal cortex (mPFC) pathway transmits itch signals and is ...
Jia-Ni Li +10 more
semanticscholar +1 more source
Peripheral itch sensitization in atopic dermatitis.
Allergology International, 2022 Atopic dermatitis is a skin disorder caused by skin dryness and barrier dysfunction, resulting in skin inflammation and chronic itch (or pruritus). The pathogenesis of atopic dermatitis is thought to be initiated by a lowering of the itch threshold due ...
M. Tominaga, K. Takamori
semanticscholar +1 more source
Itch: from the skin to the brain – peripheral and central neural sensitization in chronic itch
Frontiers in Molecular Neuroscience, 2023 Similar to chronic pain, chronic itch is frequently linked to neural sensitization, a phenomenon wherein the nervous system becomes hypersensitive to stimuli.
O. Mahmoud +3 more
semanticscholar +1 more source
Representation and control of pain and itch by distinct prefrontal neural ensembles.
Neuron, 2023 Pain and itch are two closely related but essentially distinct sensations that elicit different behavioral responses. However, it remains mysterious how pain and itch information is encoded in the brain to produce differential perceptions.
Qian Pan +8 more
semanticscholar +1 more source
Itch and Janus Kinase Inhibitors
Acta Dermato-Venereologica, 2023 Itch is a common skin symptom, with complex aetiology and pathogenesis. It is mediated by 2 pathways, the histaminergic and non-histaminergic pathways.
Yujin Han +4 more
semanticscholar +1 more source
Similarities and Differences in Peripheral Itch and Pain Pathways in Atopic Dermatitis.
Journal of Allergy and Clinical Immunology, 2023 Atopic dermatitis (AD) is predominantly characterized by intense itching, but concomitant skin pain is experienced by more than 40% of patients. Patients with AD display considerable somatosensory aberrations including increased nerve sensitivity to itch
G. Yosipovitch +8 more
semanticscholar +1 more source
Sensory neuronal STAT3 is critical for IL-31 receptor expression and inflammatory itch.
Cell Reports, 2023 IL-31 receptor blockade suppresses pruritus of atopic dermatitis. However, cell-type-specific contributions of IL-31 receptor to itch, its expression mechanism, and the downstream signaling pathway to induce itch remain unknown.
Sonoko Takahashi +10 more
semanticscholar +1 more source