Acta Dermato-Venereologica, 2022 Chronic itch can severely affect quality of life. Patients report that their chronic itch can be exacerbated by exposure to warm conditions (“warmth hyperknesis”).
Daniele Riccio +2 more
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Pain and itch coding mechanisms of polymodal sensory neurons
Cell Reports, 2023 Summary: Pain and itch coding mechanisms in polymodal sensory neurons remain elusive. MrgprD+ neurons represent a major polymodal population and mediate both mechanical pain and nonhistaminergic itch. Here, we show that chemogenetic activation of MrgprD+
Changxiong Guo +10 more
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Distinct roles of NMB and GRP in itch transmission [PDF]
, 2017 A key question in our understanding of itch coding mechanisms is whether itch is relayed by dedicated molecular and neuronal pathways. Previous studies suggested that gastrin-releasing peptide (GRP) is an itch-specific neurotransmitter. Neuromedin B (NMB)
Bardoni, Rita +16 more
core +3 more sources
Assessing acute itch intensity : general labelled magnitude scale is more reliable than classic visual analogue scale [PDF]
, 2016 The reliable measurement of itch intensity is crucial, both in research as well as clinical contexts. For example, when the reliability of a measurement scale is unknown, it is impossible to determine whether a patient has changed sufficiently to be ...
Holle, Henning +3 more
core +2 more sources
Emerging Methods to Objectively Assess Pruritus in Atopic Dermatitis. [PDF]
, 2019 INTRODUCTION:Atopic dermatitis (AD) is an inflammatory skin disease with a chronic, relapsing course. Clinical features of AD vary by age, duration, and severity but can include papules, vesicles, erythema, exudate, xerosis, scaling, and lichenification.
Bhutani, Tina +7 more
core +1 more source
Chronic itch development in sensory neurons requires BRAF signaling pathways [PDF]
, 2013 Chronic itch, or pruritus, is associated with a wide range of skin abnormalities. The mechanisms responsible for chronic itch induction and persistence remain unclear.
Barry, Devin M. +17 more
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A test-retest reliability study of human experimental models of histaminergic and non-histaminergic itch [PDF]
, 2017 Numerous exploratory, proof-of-concept and interventional studies have used histaminergic and non-histaminergic human models of itch. However, no reliability studies for such surrogate models have been conducted.
Andersen, Hjalte Holm +7 more
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Attentional Bias Towards Visual Itch and Pain Stimuli in Itch- and Pain-free Individuals?
Acta Dermato-Venereologica, 2020 Itch and pain are important attention-demanding sensations that allow adaptive responses to potential bodily harm. An attentional bias towards itch and pain stimuli, i.e.
Jennifer M. Becker +6 more
doaj +1 more source
Environmental influences on induction of itching and scratching using immersive virtual reality
Scientific Reports, 2023 Chronic itching is a serious and uncomfortable condition. The scratch response might result in a vicious cycle of alternating itching and scratching.
Emmy W. T. van de Burgt +3 more
doaj +1 more source
Recognition mechanism of p63 by the E3 ligase Itch Novel strategy in the study and inhibition of this interaction. [PDF]
, 2012 The HECT-containing E3 ubiquitin ligase Itch mediates the degradation of several proteins, including p63 and p73, involved in cell specification and fate.
Barbato, G +4 more
core +1 more source