Results 21 to 30 of about 34,079 (294)
Cell, 2009 The itch sensation results from the excitation of primary sensory nerve endings in the skin, but the underlying molecular mechanisms are not completely understood. Liu et al. (2009) now report that some members of the Mrgpr class of G protein-coupled receptors mediate the itch caused by the antimalarial drug chloroquine.
Ardem Patapoutian +2 more
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Allergology International, 2017 Itch is an unpleasant cutaneous sensation that can arise following insect bites, exposure to plant ingredients, and some diseases. Itch can also have idiopathic causes. Itch sensations are thought to protect against external insults and toxic substances.
Hiroki Kittaka, Makoto Tominaga
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A tactile twist: decoding the phenomena of mechanical itch and alloknesis
Frontiers in Molecular Neuroscience, 2023 Itch is a sensation in the skin which provokes the desire to scratch. In the past few decades there has been a significant elucidation of the immune and neural pathways which underly the sensation of itch.
Taylor Follansbee, Xinzhong Dong
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Neuroimmune Mediators of Pruritus in Hispanic Scalp Psoriatic Itch
Acta Dermato-Venereologica, 2023 Scalp psoriatic itch is a common, bothersome, yet understudied, condition with numerous associated treatment challenges. The aim of this study was to enhance our understanding of the pathophysiology of scalp psoriatic itch.
Leigh A. Nattkemper +6 more
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Management of Itch in the Elderly: A Review
Dermatology and Therapy, 2019 Chronic itch is common in the elderly patient and may be caused by a variety of known dermatologic and non-dermatologic conditions and can have a significant effect on quality of life.
Kayla M. Fourzali, Gil Yosipovitch
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Brain, 2013 Research over the past 15 years has helped to clarify the anatomy and physiology of itch, the clinical features of neuropathic itch syndromes and the scientific underpinning of effective treatments. Two itch-sensitive pathways exist: a histamine-stimulated pathway that uses mechanically insensitive C-fibres, and a cowhage-stimulated pathway primarily ...
Michael J. Aminoff, Amar Dhand
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Clinical and Experimental Dermatology, 2005 The study of itch remains a neglected field, with a number of barriers limiting satisfactory therapy in the majority of instances. We review recent advances, focusing on the identification of the neural pathways, distinct from pain, that signal itch; methods to measure itch as scratch in humans; and the identification of a role for H4 receptors in ...
Jonathan L. Rees, C. S. Murray
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Neutrophils promote CXCR3-dependent itch in the development of atopic dermatitis
eLife, 2019 Chronic itch remains a highly prevalent disorder with limited treatment options. Most chronic itch diseases are thought to be driven by both the nervous and immune systems, but the fundamental molecular and cellular interactions that trigger the ...
Carolyn M Walsh +11 more
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An Altered Skin and Gut Microbiota Are Involved in the Modulation of Itch in Atopic Dermatitis
Cells, 2022 Skin and gut microbiota play an important role in the pathogenesis of atopic dermatitis (AD). An alteration of the microbiota diversity modulates the development and course of AD, e.g., decreased microbiome diversity correlates with disease severity ...
Catharina Sagita Moniaga +2 more
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Environmental influences on induction of itching and scratching using immersive virtual reality
Scientific Reports, 2023 Chronic itching is a serious and uncomfortable condition. The scratch response might result in a vicious cycle of alternating itching and scratching.
Emmy W. T. van de Burgt +3 more
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