Results 31 to 40 of about 362 (130)
ABSTRACT Objective While tumor‐infiltrating lymphocytes (TILs) are prognostic in various cancers, their role in small bowel adenocarcinoma (SBA) is unexplored. This study evaluates the prognostic significance of digitally quantified TILs in SBA. Methods Using digital pathology (QuPath) on hematoxylin and eosin (H&E)‐stained slides from 62 SBA cases, we
Minying Deng +12 more
wiley +1 more source
Purpose The prognostic significance of tumor-infiltrating lymphocytes (TILs) in colorectal cancer (CRC) is well established; however, existing approaches inadequately capture their spatial distribution.
Hyun-Hee Koh +9 more
doaj +1 more source
ABSTRACT Background Cervical cancer (CC) is a main malignancy affecting women globally, with a high mortality rate. Chemoradiotherapy resistance is a significant factor in determining treatment outcomes, and prognostic biomarkers are essential for the appropriate selection of therapeutic strategies.
Angelo Borges de Melo Neto +14 more
wiley +1 more source
Preoperative Evaluation in Obstructive Sleep Apnea Syndrome
In patients with Obstructive sleep apnea syndrome (OSAS), preoperative evaluation should be routinely done in all patients with OSAS undergoing surgery or in all patients suspected to have OSAS to avoid problems during perioperative (pre-intra-post ...
Oya İtil
doaj +1 more source
We retrospectively enrolled breast cancer patients receiving neoadjuvant therapy from multiple centers. We analyzed digital whole‐slide images, extracted pathological features, and built integrated prediction models combining pathological features and text information.
Yani Wei +14 more
wiley +1 more source
Our study demonstrates that the angiotensin receptor blocker losartan enhances the efficacy of radiotherapy in triple‐negative breast cancer by reversing the immunosuppressive tumor microenvironment. Losartan reprograms tumor‐associated macrophages, inhibits myeloid‐derived suppressor cell function, and boosts CD8+ T‐cell activity.
Xu Wang +8 more
wiley +1 more source
T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu +7 more
wiley +1 more source
The article deals with methodology for description of scientifi c and educational services in education and information on the basis of interoperability stack EIF (European Interoperability Framework).
Ekaterina V. Pavlova
doaj +1 more source
Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu +4 more
wiley +1 more source
ABSTRACT In a previous paper, we showed in children 6–12 years old that a resting‐state (RS) eyes‐open dark room (DR) task provides RS parietal‐occipital alpha measures similar to those obtained using the standard RS eyes‐closed (EC) exam. Results provided initial evidence that the RS DR procedure is feasible and useful with populations often excluded ...
Marybeth McNamee +14 more
wiley +1 more source

