Results 31 to 40 of about 362 (130)

An Open Source Automated Tumor Infiltrating Lymphocytes Algorithm for Prognosis in Primary Small Bowel Adenocarcinoma Using Routine Hematoxylin and Eosin Stained Sections

open access: yesCancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Objective While tumor‐infiltrating lymphocytes (TILs) are prognostic in various cancers, their role in small bowel adenocarcinoma (SBA) is unexplored. This study evaluates the prognostic significance of digitally quantified TILs in SBA. Methods Using digital pathology (QuPath) on hematoxylin and eosin (H&E)‐stained slides from 62 SBA cases, we
Minying Deng   +12 more
wiley   +1 more source

Artificial intelligence-powered H&E-based quantification of spatial tumor-infiltrating lymphocyte distribution identifies prognostic immune niches in colorectal cancer

open access: yesCancer Immunology, Immunotherapy
Purpose The prognostic significance of tumor-infiltrating lymphocytes (TILs) in colorectal cancer (CRC) is well established; however, existing approaches inadequately capture their spatial distribution.
Hyun-Hee Koh   +9 more
doaj   +1 more source

ATF4, ZIK1, and PNMA3 Transcriptomic Signatures Predict Chemoradiotherapy Response in Cervical Cancer

open access: yesCancer Medicine, Volume 15, Issue 8, August 2026.
ABSTRACT Background Cervical cancer (CC) is a main malignancy affecting women globally, with a high mortality rate. Chemoradiotherapy resistance is a significant factor in determining treatment outcomes, and prognostic biomarkers are essential for the appropriate selection of therapeutic strategies.
Angelo Borges de Melo Neto   +14 more
wiley   +1 more source

Preoperative Evaluation in Obstructive Sleep Apnea Syndrome

open access: yesTürk Uyku Tıbbı Dergisi, 2015
In patients with Obstructive sleep apnea syndrome (OSAS), preoperative evaluation should be routinely done in all patients with OSAS undergoing surgery or in all patients suspected to have OSAS to avoid problems during perioperative (pre-intra-post ...
Oya İtil
doaj   +1 more source

Development and Validation of a Pathomics Model for Prognosis Prediction in Neoadjuvant Therapy‐Treated Breast Cancer: A Retrospective, Multicenter Study

open access: yesMedComm, Volume 7, Issue 7, July 2026.
We retrospectively enrolled breast cancer patients receiving neoadjuvant therapy from multiple centers. We analyzed digital whole‐slide images, extracted pathological features, and built integrated prediction models combining pathological features and text information.
Yani Wei   +14 more
wiley   +1 more source

Losartan Enhances Radiosensitivity by Reversing Immunosuppressive Tumor Microenvironment Induced by Radiotherapy in TNBC

open access: yesCancer Science, Volume 117, Issue 7, Page 1795-1812, July 2026.
Our study demonstrates that the angiotensin receptor blocker losartan enhances the efficacy of radiotherapy in triple‐negative breast cancer by reversing the immunosuppressive tumor microenvironment. Losartan reprograms tumor‐associated macrophages, inhibits myeloid‐derived suppressor cell function, and boosts CD8+ T‐cell activity.
Xu Wang   +8 more
wiley   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

open access: yesAdvanced Science, Volume 13, Issue 35, 24 June 2026.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu   +7 more
wiley   +1 more source

METHODS FOR DESCRIPTION OF EDUCATION AND SCIENTIFIC SERVICES IN INFORMATION AND EDUCATION ON THE BASIS OF INTEROPERABILITY STACK EIF

open access: yesОткрытое образование (Москва), 2016
The article deals with methodology for description of scientifi c and educational services in education and information on the basis of interoperability stack EIF (European Interoperability Framework).
Ekaterina V. Pavlova
doaj   +1 more source

Leveraging Artificial Intelligence and Large Language Models for Cancer Immunotherapy

open access: yesAdvanced Science, Volume 13, Issue 35, 24 June 2026.
Cancer immunotherapy faces challenges in predicting treatment responses and understanding resistance mechanisms. Artificial intelligence (AI) and machine learning (ML) offer powerful solutions for cancer immunotherapy in patient stratification, biomarker discovery, treatment strategy optimization, and foundation model development.
Xinchao Wu   +4 more
wiley   +1 more source

Confirmation of a Useful Dark‐Room Resting‐State Procedure: Periodic and Aperiodic MEG Activity in Children

open access: yesPsychophysiology, Volume 63, Issue 2, February 2026.
ABSTRACT In a previous paper, we showed in children 6–12 years old that a resting‐state (RS) eyes‐open dark room (DR) task provides RS parietal‐occipital alpha measures similar to those obtained using the standard RS eyes‐closed (EC) exam. Results provided initial evidence that the RS DR procedure is feasible and useful with populations often excluded ...
Marybeth McNamee   +14 more
wiley   +1 more source

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