Results 61 to 70 of about 33,630 (280)

Photosensitizing Lipid Nanoparticles for Ferroptosis‐Enhanced Photodynamic Cancer Therapy via GPX4 Silencing

Advanced Healthcare Materials, EarlyView.
Photosensitizing lipid nanoparticles (PLNPs) are engineered by incorporating cholesterol–PEG–pheophorbide a into MC3‐based LNPs and encapsulating GPX4‐targeting siRNA. Upon light activation, PLNPs generate reactive oxygen species (ROS) while silencing GPX4 to induce ferroptosis.
Ga‐Hyun Bae, Seungyong Shin, Joo Dong Park, Eun‐Young Koh, Seunghyo Ko, Jieun Han, Chun Gown Park, Dong‐Hyun Kim, Kun Na, Wooram Park   +9 more
wiley   +1 more source

Effects of resveratrol-loaded dendrimer nanomedicine on hepatocellular carcinoma cells

Frontiers in Immunology
Resveratrol (Res), a Chinese herbal extract, has demonstrated a remarkable and distinct antitumor effect, characterized by prolonged efficacy and minimal adverse reactions.
Jiao Qu, Yueqin Zhang, Cong Song, Yue Wang   +3 more
doaj   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Decolorization of the benzidine-based azo dye Congo red by the new strain Shewanella xiamenensis G5-03

Brazilian Journal of Biology, 2021
Shewanella xiamenensis G5-03 was observed to decolorize the azo dye Congo red in synthetic wastewater. The influence of some factors on the dye decolorization efficiency was evaluated.
E. R. Silva, E. L. Dall’Oglio, L. G. Vasconcelos, E. B. Morais   +3 more
doaj   +1 more source

Understanding and Circumventing Failure Mechanisms in Chalcogenide Optical Phase Change Material Ge2Sb2Se4Te

Advanced Optical Materials, Volume 13, Issue 8, March 13, 2025.
Chalcogenide optical PCMs have gathered interest for their potential in compact, non‐volatile optics and photonics. Free‐space PCM metasurfaces require new considerations from phase change memory that need to be addressed for reliable scale‐up. Several failure mechanisms pertaining to free‐space PCM devices and layout methods are isolated to prevent ...
Cosmin Constantin Popescu, Kiumars Aryana, Brian Mills, Tae Woo Lee, Louis Martin‐Monier, Luigi Ranno, Jia Xu Brian Sia, Khoi Phuong Dao, Hyung‐Bin Bae, Vladimir Liberman, Steven A. Vitale, Myungkoo Kang, Kathleen A. Richardson, Carlos A. Ríos Ocampo, Dennis Calahan, Yifei Zhang, William M. Humphreys, Hyun Jung Kim, Tian Gu, Juejun Hu   +19 more
wiley   +1 more source

ROS Activated NETosis of Bone Marrow CD55+ Intermediate Mature Neutrophils Through HIF1α‐PADI4 Pathway to Initiate Bone Aging

Advanced Science, EarlyView.
In this study, we find CD55+ neutrophils show activated NETosis within bone marrow, induce BMSC senescence and osteogenesis inhibition, finally leading to bone aging initiation. Mechanistically, ROS synergizes with the CD55‐driven HIF1α‐PADI4 pathway to promote NETosis.
Yutong Guo, Shengjie Cui, Xi Wen, Yidi Wang, Ben Wu, Yixiang Wang, Yan Gu   +6 more
wiley   +1 more source

Update Delay: A new Information-Centric Metric for a Combined Communication and Application Level Reliability Evaluation of CAM based Safety Applications [PDF]

, 2012
Standard network metrics, such as throughput, latency and reception probability, are the most popular performance indicators used in the literature to describe and compare communication protocol variations. However, these “traditional” network-centric PI
Härri, Jérôme, Kloiber, Bernhard, Rico-Garcia, Cristina, Strang, Thomas   +3 more
core  

Gαi1/3 Is a Novel Regulatory Target for RANKL Signal Transduction and Osteoporosis

Advanced Science, EarlyView.
ABSTRACT Osteoporosis, characterized by progressive bone loss and increased fracture risk, is a growing concern as the population ages. Current treatments, though advanced, remain limited, underscoring the necessity for novel therapeutic targets. Recent studies have shown that the immune system plays a key role in osteoporosis, with osteoclasts driving
Chaowen Bai, Mingchao Zhang, Le Liu, Lide Tao, Chenyang Xu, Hao Chai, Xin Shi, Yin Wang, Xiaopei Zhang, Qiong Chen, Dong Liu, Jinyu Bai, Chang She, Xiaozhong Zhou, Cong Cao, Huajian Shan   +15 more
wiley   +1 more source

Kidney Function Trajectories with Tolvaptan in ADPKD Patients with CKD-G5

Kidney International Reports
Introduction: Improvement of estimated glomerular filtration rate (eGFR) slope has been established using tolvaptan in patients with Autosomal Dominant Polycystic Kidney Disease (ADPKD).
Akinari Sekine, Junichi Hoshino, Toshio Mochizuki, Shinya Nakatani, Saori Nishio, Tatsuya Suwabe, Hiroki Hayashi, Hirayasu Kai, Koichi Seta, Fumihiko Hattanda, Sumi Hidaka, Kazushige Hanaoka, Mahiro Kurashige, Hiroshi Kataoka, Kiyotaka Uchiyama, Keiji Shimazu, Eiji Ishikawa, Yosuke Shimada, Haruna Kawano, Ken Tsuchiya, Shigeo Horie, Ichiei Narita, Yoshitaka Isaka, Satoru Muto   +23 more
doaj   +1 more source

ITS‐G5 performance improvement and evaluation for vulnerable road user safety services

IET Intelligent Transport Systems, 2017
Cooperative intelligent transportation system (C‐ITS) allows to improve safety of vehicles through communications between vehicles and infrastructure. C‐ITS may also improve the safety of vulnerable road users (VRUs), but work on this issue is still in an early stage.
Scholliers Johan, Kujanpää Kaisa, Valta Mikko, Jutila Mirjami   +3 more
openaire   +2 more sources