Results 21 to 30 of about 5,515 (141)

Ivabradine Prevents Low Shear Stress Induced Endothelial Inflammation and Oxidative Stress via mTOR/eNOS Pathway. [PDF]

PLoS ONE, 2016
Ivabradine not only reduces heart rate but has other cardiac and vascular protective effects including anti-inflammation and anti-oxidation. Since endothelial nitric oxide synthase (eNOS) is a crucial enzyme in maintaining endothelial activity, we aimed ...
Bing Li, Junxia Zhang, Zhimei Wang, Shaoliang Chen   +3 more
doaj   +1 more source

Locally injected ivabradine inhibits carrageenan-induced pain and inflammatory responses via hyperpolarization-activated cyclic nucleotide-gated (HCN) channels.

PLoS ONE, 2019
BackgroundRecently, attention has been focused on the role of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels in the mechanism of and as a treatment target for neuropathic and inflammatory pain.
Saki Miyake, Hitoshi Higuchi, Yuka Honda-Wakasugi, Maki Fujimoto, Hotaka Kawai, Hitoshi Nagatsuka, Shigeru Maeda, Takuya Miyawaki   +7 more
doaj   +1 more source

Ivabradin [PDF]

pharma-kritik, 2008
Mit einer neuen Wirkungsweise erreicht Ivabradin eine ähnliche antianginöse Wirkung wie Atenolol oder Amlodipin. Als Prophylaxe gegen koronare Ereignisse scheint die teure Innovation jedoch nicht wirksam.
openaire   +1 more source

Impact of Ivabradine on Inflammatory Markers in Chronic Heart Failure

Journal of Immunology Research, 2016
Background. Inflammation plays a crucial role in the progression of chronic heart failure (CHF). Ivabradine is known to reduce the morbidity and mortality of patients with CHF under certain conditions.
Ilonka Rohm, Daniel Kretzschmar, Rudin Pistulli, Marcus Franz, P. Christian Schulze, Christian Stumpf, Atilla Yilmaz   +6 more
doaj   +1 more source

Identification of the molecular site of ivabradine binding to HCN4 channels.

PLoS ONE, 2013
Ivabradine is a specific heart rate-reducing agent approved as a treatment of chronic stable angina. Its mode of action involves a selective and specific block of HCN channels, the molecular components of sinoatrial "funny" (f)-channels.
Annalisa Bucchi, Mirko Baruscotti, Marco Nardini, Andrea Barbuti, Stefano Micheloni, Martino Bolognesi, Dario DiFrancesco   +6 more
doaj   +1 more source

The Biological Effects of Ivabradine in Cardiovascular Disease

Molecules, 2012
A large number of studies in healthy and asymptomatic subjects, as well as patients with already established cardiovascular disease (CAD) have demonstrated that heart rate (HR) is a very important and major independent cardiovascular risk factor for ...
Graziano Riccioni, Sara Franceschelli, Lorenza Speranza   +2 more
doaj   +1 more source

Clinical pharmacology and prescribing education: An updated medical school curriculum from the British Pharmacological Society

British Journal of Clinical Pharmacology, EarlyView.
Aims Prescribing is a complex, essential skill that doctors must acquire to practice medicine safely and effectively. The British Pharmacological Society has historically provided a core curriculum to guide clinical pharmacology and prescribing education in UK medical schools.
Dagan O. Lonsdale, Clare Guilding, Jennifer Koenig, Michael Okorie, Reecha Sofat, Simon Maxwell   +5 more
wiley   +1 more source

Ivabradine [PDF]

Reactions Weekly, 2020
  +6 more sources

MELD score predicts outcomes in patients with advanced heart failure: A longitudinal evaluation

ESC Heart Failure, Volume 12, Issue 2, Page 839-847, April 2025.
Abstract Aims Advanced heart failure (AHF) is characterized by recurrent episodes of haemodynamic instability and frequent hospitalizations, leading to a progressive decline in quality of life and high mortality rates. The objectives of this study were to evaluate the effect of the model for end‐stage liver disease (MELD) score and its variations in ...
Francesco Curcio, Cristiano Amarelli, Rosaria Chiappetti, Irene Mattucci, Veronica Flocco, Mahmoud Issa Rammal, Ciro Abete, Francesca Mazzella, Ciro Maiello, Pasquale Abete, Francesco Cacciatore   +10 more
wiley   +1 more source

Preserved Autonomic Cardiovascular Regulation With Cardiac Pacemaker Inhibition: A Crossover Trial Using High‐Fidelity Cardiovascular Phenotyping

Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease, 2016
BackgroundSympathetic and parasympathetic influences on heart rate (HR), which are governed by baroreflex mechanisms, are integrated at the cardiac sinus node through hyperpolarization‐activated cyclic nucleotide–gated channels (HCN4).
Karsten Heusser, Jens Tank, Julia Brinkmann, Christoph Schroeder, Marcus May, Anika Großhennig, Daniela Wenzel, André Diedrich, Fred C. G. J. Sweep, Heidrun Mehling, Friedrich C. Luft, Jens Jordan   +11 more
doaj   +1 more source