Results 51 to 60 of about 5,515 (141)

Managing High‐Risk Drug Interactions With Nirmatrelvir/Ritonavir: Experience From a Dedicated Pharmacology Advice Service

Clinical and Translational Science, Volume 19, Issue 3, March 2026.
ABSTRACT Nirmatrelvir boosted with ritonavir is a key antiviral against COVID‐19, yet ritonavir's potent CYP3A4 inhibition exposes patients to numerous drug–drug interactions. To make prescribing safer, a national proactive system providing expert pharmacology advice was implemented in France.
Youssef Libiad, Bénédicte Franck, Camille Tron, Sébastien Lalanne, Christelle Boglione‐Kerrien, Fabrice Taïeb, Marie‐Clémence Verdier, Florian Lemaitre   +7 more
wiley   +1 more source

Current Trends in Duchenne Muscular Dystrophy Research and Therapy: 3D Cardiac Modelling

Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 1, February 2026.
ABSTRACT Duchenne muscular dystrophy (DMD), caused by dystrophin deficiency, presents a multifaceted challenge that affects both skeletal muscle function and cardiomyocyte homeostasis, causing progressive degeneration and life‐threatening cardiac complications by adolescence.
Marta Przymuszała, Marta Białobrzeska, Józef Dulak, Urszula Florczyk‐Soluch   +3 more
wiley   +1 more source

Cardiac Resynchronization Therapy: Reconsidering Its Essence as a Treatment for Electrical Dyssynchrony in Heart Failure

Journal of Arrhythmia, Volume 42, Issue 1, February 2026.
Flow of cardiac resynchronization therapy (CRT) in heart failure management. Heart failure (HF) patients with electrical dyssynchrony are first identified through screening. If electrical dyssynchrony contributes to HF deterioration, CRT is initiated to improve electrical synchrony.
Michio Ogano, Yu‐ki Iwasaki, Jun Tanabe, Wataru Shimizu, Kuniya Asai   +4 more
wiley   +1 more source

EFFICACY AND SAFETY OF IVABRADINE AND BISOPROLOL IN PATIENTS WITH ISCHEMIC HEART DISEASE: RESULTS OF COMPARATIVE RANDOMIZED OPEN STUDY

Рациональная фармакотерапия в кардиологии, 2016
Aim. To study influence of ivabradine as compared with bisoprolol on clinical and hemodynamic indices, exercise tolerance, endothelial function, quality of life (QL) and erectile function in patients with ischemic heart disease. Material and methods.
R. D. Kurbanov, A. O. Kan, F. M. Bekmetova, A. B. Shek   +3 more
doaj   +1 more source

Population Physiologically‐Based Pharmacokinetic Modeling to Determine Ontogeny: A Quantitative Clinical Pharmacology Example in Pediatric Rare Disease

CPT: Pharmacometrics &Systems Pharmacology, Volume 15, Issue 2, February 2026.
ABSTRACT Pediatric physiologically‐based pharmacokinetic (PBPK) modelling plays an increasing role in selecting doses in children and addressing clinical pharmacology questions. Ethical concerns often limit clinical pharmacology studies that have no direct therapeutic benefit in children, highlighting the value of PBPK model predictions.
Yumi Cleary, Bhagwat Prasad, Kayode Ogungbenro, Michael Gertz, Aleksandra Galetin   +4 more
wiley   +1 more source

Acute Effects of Ivabradine on Dynamic Obstruction of the Left Ventricular Outflow Tract in Cats with Preclinical Hypertrophic Cardiomyopathy

Journal of Veterinary Internal Medicine, 2014
Background Ivabradine is a negative chronotropic drug with minimal effects on central hemodynamics. Its effect on dynamic obstruction of the left ventricular outflow tract (LVOT) in cats with hypertrophic cardiomyopathy (HCM) remains unknown.
K.A. Blass, K.E. Schober, X. Li, B.A. Scansen, J.D. Bonagura   +4 more
doaj   +1 more source

Optochemical modulation of corneal cold nerve terminal impulse activity with a photochromic ion channel blocker

British Journal of Pharmacology, Volume 183, Issue 3, Page 545-559, February 2026.
Background and Purpose The functional organization of corneal cold nerve endings, critical structures in maintaining the ocular surface, remains poorly understood. Here, the photoisomerizable small‐molecule diethylamine‐azobenzene‐quaternary ammonium (DENAQ) was used to photomodulate activity of cold‐sensing nerve terminals in control and chronic tear ...
David Ares‐Suárez, Almudena Iñigo‐Portugués, Enrique Velasco, Susana Quirce, Fernando Aleixandre‐Carrera, Ariadna Díaz‐Tahoces, M. Carmen Acosta, Wan‐Chen Lin, Richard H. Kramer, Carlos Belmonte, Juana Gallar, Victor Meseguer   +11 more
wiley   +1 more source

Effects of adding ivabradine to usual care in patients with angina pectoris: a systematic review of randomised clinical trials with meta-analysis and Trial Sequential Analysis

Open Heart, 2020
Objective To determine the impact of ivabradine on outcomes important to patients with angina pectoris caused by coronary artery disease.Methods We conducted a systematic review.
Janus Christian Jakobsen, Christian Gluud, Emil Eik Nielsen, Mathias Maagaard, Naqash Javaid Sethi, Liang Ning, Si-hong Yang   +6 more
doaj   +1 more source

Association of Weight Loss Composition Following Metabolic‐Bariatric Surgery With Incident Major Adverse Cardiovascular Events and All‐Cause Mortality

Clinical Obesity, Volume 16, Issue 1, February 2026.
ABSTRACT Severe obesity is associated with an increased cardiovascular risk. Metabolic‐bariatric surgery (MBS) can reduce the risk of cardiovascular events and mortality, potentially depending on weight loss composition. This study assessed the association between post‐MBS weight loss composition and major adverse cardiovascular events (MACE) and all ...
Malou A. H. Nuijten, Bente M. de Roos, Jan H. M. Karregat, Eric J. Hazebroek, Valerie M. Monpellier, Ignace M. C. Janssen, Maria T. E. Hopman, Esmée A. Bakker, Thijs M. H. Eijsvogels   +8 more
wiley   +1 more source

Effectiveness and safety of combining thiazides with loop diuretics vs. loop diuretics monotherapy in patients with acute decompensated heart failure: A retrospective cohort study

British Journal of Clinical Pharmacology, Volume 92, Issue 1, Page 220-229, January 2026.
Aims This study investigated factors associated with and outcomes of combined loop diuretics with hydrochlorothiazide (HCTZ) for acute decompensated heart failure (ADHF). Methods In this retrospective study, adults hospitalized for ADHF and who received intravenous loop diuretics between January 2016 and March 2023 were enrolled.
Chia‐Chen Hsu, Hsien‐Chih Chiu, Ju‐Chieh Wung, Yueh‐Ching Chou, Yuh‐Lih Chang, Chian‐Ying Chou, Chin‐Chou Huang   +6 more
wiley   +1 more source