Treatment of cattle with ivermectin and its effect on dung degradation and larval abundance in a tropical savanna setting [PDF]
One HealthWhen ingested as part of a blood meal, the antiparasitic drug ivermectin kills mosquitoes, making it a candidate for mass drug administration (MDA) in humans and livestock to reduce malaria transmission. When administered to livestock, most ivermectin is
Miriam Ruhinda +9 more
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Impact of standard and long-lasting ivermectin formulations in cattle and buffalo on wild Anopheles survival on Sumba Island, Indonesia [PDF]
Scientific ReportsThe mosquito-lethal effect of commercially available standard and long-lasting ivermectin formulations were evaluated in cattle and buffalo against wild-caught Anopheles on Sumba Island, Indonesia.
Kevin C. Kobylinski +13 more
doaj +2 more sources
Acute toxicity events of ivermectin in chicks’ model [PDF]
Iraqi Journal of Veterinary Sciences, 2022 Ivermectin is a very safe drug; however, there are many studies on its toxic effects in different animals due to sensitivity, misuse, or accidental overdose.
Tamara K. Al-Najmawi, Muna H. Al-Zubaidy
doaj +1 more source
In vitro larvicidal activity of ivermectin and povidone-iodine against Oestrus ovis.
PLoS ONE, 2021 PurposeTo assess the in vitro larvicidal activity of ivermectin and povidone-iodine (PVP-I) against Oestrus ovis, the most frequent cause of external ophthalmomyiasis.MethodsL1 O.
Giuseppe D'Amico Ricci +6 more
doaj +2 more sources
Ivermectin metabolites reduce Anopheles survival
Scientific Reports, 2023 Ivermectin mass drug administration to humans or livestock is a potential vector control tool for malaria elimination. The mosquito-lethal effect of ivermectin in clinical trials exceeds that predicted from in vitro laboratory experiments, suggesting ...
Kevin C. Kobylinski +14 more
doaj +1 more source
Using Twitter Data to Understand Public Perceptions of Approved versus Off-label Use for COVID-19-related Medications [PDF]
amiajnl-2022-012337.R1, 2022 Understanding public discourse on emergency use of unproven therapeutics is crucial for monitoring safe use and combating misinformation. We developed a natural language processing-based pipeline to comprehend public perceptions of and stances on coronavirus disease 2019 (COVID-19)-related drugs on Twitter over time.
arxiv +1 more source
Current therapeutic applications and pharmacokinetic modulations of ivermectin [PDF]
Veterinary World, 2019 Ivermectin is considered to be a wonder drug due to its broad-spectrum antiparasitic activity against both ectoparasites and endoparasites (under class of endectocide) and has multiple applications in both veterinary and human medicine.
Khan Sharun +5 more
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Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes
Malaria Journal, 2023 Background Ivermectin (22,23-dihydroavermectin B1a: H2B1a) is an endectocide used to treat worm infections and ectoparasites including lice and scabies mites.
Charlotte Kern +5 more
doaj +1 more source
Integrated analysis reveals FOXA1 and Ku70/Ku80 as targets of ivermectin in prostate cancer
Cell Death and Disease, 2022 Ivermectin is a widely used antiparasitic drug and shows promising anticancer activity in various cancer types. Although multiple signaling pathways modulated by ivermectin have been identified in tumor cells, few studies have focused on the exact target
Shidong Lv +7 more
doaj +1 more source
Insights from a computational analysis of the SARS-CoV-2 Omicron variant: Host-pathogen interaction, pathogenicity and possible therapeutics [PDF]
Immunity, Inflammation and Disease 10 (2022), e639, 2022 Prominently accountable for the upsurge of COVID-19 cases as the world attempts to recover from the previous two waves, Omicron has further threatened the conventional therapeutic approaches. Omicron is the fifth variant of concern (VOC), which comprises more than 10 mutations in the receptor-binding domain (RBD) of the spike protein. However, the lack
arxiv +1 more source