Results 21 to 30 of about 48,951 (258)

Antiparasitic activity of ivermectin: Four decades of research into a "wonder drug".

European journal of medicinal chemistry, 2023
Parasitic diseases still pose a serious threat to human and animal health, particularly for millions of people and their livelihoods in low-income countries.
Michał Sulik, M. Antoszczak, Adam Huczyński, Dietmar Steverding   +3 more
semanticscholar   +1 more source

Randomized Trial of Metformin, Ivermectin, and Fluvoxamine for Covid-19

New England Journal of Medicine, 2022
BACKGROUND Early treatment to prevent severe coronavirus disease 2019 (Covid-19) is an important component of the comprehensive response to the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic.
C. Bramante, J. Huling, C. Tignanelli, J. B. Buse, D. Liebovitz, J. Nicklas, Kenneth Cohen, M. Puskarich, H. Belani, J. Proper, L. Siegel, N. Klatt, D. Odde, Darlette G. Luke, Blake Anderson, Amy B. Karger, N. Ingraham, K. Hartman, V. Rao, Aubrey A Hagen, Barkha P Patel, S. Fenno, N. Avula, Neha V. Reddy, S. M. Erickson, S. Lindberg, R. Fricton, Samuel Lee, A. Zaman, Hanna G Saveraid, Walker J Tordsen, M. Pullen, M. Biros, Nancy E. Sherwood, Jennifer L Thompson, D. Boulware, T. Murray   +36 more
semanticscholar   +1 more source

In vitro larvicidal activity of ivermectin and povidone-iodine against Oestrus ovis.

PLoS ONE, 2021
PurposeTo assess the in vitro larvicidal activity of ivermectin and povidone-iodine (PVP-I) against Oestrus ovis, the most frequent cause of external ophthalmomyiasis.MethodsL1 O.
Giuseppe D'Amico Ricci, Giovanni Garippa, Stefano Cortese, Rita Serra, Francesco Boscia, Stefano Dore, Antonio Pinna   +6 more
doaj   +2 more sources

Repurposing antimicrobial agents for neuroprotection: Mechanisms, clinical potential, and challenges. [PDF]

Neuroprotection
Antimicrobial agents exert neuroprotective effects through modulation of interconnected pathways. Tetracyclines, macrolides, antimalarial agents, sulfones, and antiparasitic agents suppress neuroinflammation, oxidative stress, and apoptosis while preserving mitochondrial function and neurotransmission.
Manavi MA, Salehi M, Mohammad Jafari R, Goudarzi R, Khosravi S, Dehpour AR.   +5 more
europepmc   +2 more sources

The effect of early treatment with ivermectin on viral load, symptoms and humoral response in patients with non-severe COVID-19: A pilot, double-blind, placebo-controlled, randomized clinical trial

EClinicalMedicine, 2021
Background Ivermectin inhibits the replication of SARS-CoV-2 in vitro at concentrations not readily achievable with currently approved doses. There is limited evidence to support its clinical use in COVID-19 patients.
Carlos J. Chaccour, A. Casellas, Andrés Blanco-Di Matteo, Íñigo Pineda, A. Fernández-Montero, Paula Ruiz-Castillo, M. Richardson, M. Rodríguez-Mateos, Carlota Jordán-Iborra, J. Brew, Francisco Carmona-Torre, M. Giráldez, E. Laso, J. Gabaldón-Figueira, C. Dobaño, G. Moncunill, J. Yuste, J. D. del Pozo, N. Rabinovich, Verena Schöning, F. Hammann, G. Reina, B. Sádaba, M. Fernández-Alonso   +23 more
semanticscholar   +1 more source

Ivermectin for preventing and treating COVID‐19

Cochrane Database of Systematic Reviews, 2021
Background Ivermectin, an antiparasitic agent used to treat parasitic infestations, inhibits the replication of viruses in vitro. The molecular hypothesis of ivermectin's antiviral mode of action suggests an inhibitory effect on severe acute respiratory ...
Maria Popp, M. Stegemann, M. Metzendorf, Susan Gould, P. Kranke, P. Meybohm, N. Skoetz, S. Weibel   +7 more
semanticscholar   +1 more source

Ivermectin for Prevention and Treatment of COVID-19 Infection: A Systematic Review, Meta-analysis, and Trial Sequential Analysis to Inform Clinical Guidelines

American Journal of Therapeutics, 2021
Background: Repurposed medicines may have a role against the SARS-CoV-2 virus. The antiparasitic ivermectin, with antiviral and anti-inflammatory properties, has now been tested in numerous clinical trials.
A. Bryant, Theresa A Lawrie, T. Dowswell, E. Fordham, S. Mitchell, Sarah R Hill, T. Tham   +6 more
semanticscholar   +1 more source

Current therapeutic applications and pharmacokinetic modulations of ivermectin [PDF]

Veterinary World, 2019
Ivermectin is considered to be a wonder drug due to its broad-spectrum antiparasitic activity against both ectoparasites and endoparasites (under class of endectocide) and has multiple applications in both veterinary and human medicine.
Khan Sharun, T. S. Shyamkumar, V. A. Aneesha, Kuldeep Dhama, Abhijit Motiram Pawde , Amar Pal   +5 more
doaj   +1 more source

The FDA-approved drug ivermectin inhibits the replication of SARS-CoV-2 in vitro

Antiviral Research, 2020
Although several clinical trials are now underway to test possible therapies, the worldwide response to the COVID-19 outbreak has been largely limited to monitoring/containment.
L. Caly, J. Druce, M. Catton, D. Jans, K. Wagstaff   +4 more
semanticscholar   +1 more source

Pharmacokinetics of ivermectin metabolites and their activity against Anopheles stephensi mosquitoes

Malaria Journal, 2023
Background Ivermectin (22,23-dihydroavermectin B1a: H2B1a) is an endectocide used to treat worm infections and ectoparasites including lice and scabies mites.
Charlotte Kern, Pie Müller, Carlos Chaccour, Matthias E. Liechti, Felix Hammann, Urs Duthaler   +5 more
doaj   +1 more source