Results 11 to 20 of about 20,717 (141)

Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: A randomized multi-center clinical trial

Asian Pacific Journal of Tropical Medicine, 2021
Objective: To evaluate different doses of ivermectin in adult patients with mild COVID-19 and to evaluate the effect of ivermectin on mortality and clinical consequences. Methods: A randomized, double-blind, placebo-controlled, multicenter clinical trial
Morteza Shakhsi Niaee, Peyman Namdar, Abbas Allami, Leila Zolghadr, Amir Javadi, Amin Karampour, Mehran Varnaseri, Behzad Bijani, Fatemeh Cheraghi, Yazdan Naderi, Fatemeh Amini, Masoumeh Karamyan, Mohammad Jafar YadYad, Ramin Jamshidian, Nematollah Gheibi   +14 more
doaj   +1 more source

Effect of Ivermectin Treatment on the Frequency of Seizures in Persons with Epilepsy Infected with Onchocerca volvulus

Pathogens, 2020
A clinical trial performed in the Democratic Republic of Congo (DRC), among persons with epilepsy (PWE) infected with Onchocerca volvulus treated with anti-seizure medication suggested that ivermectin reduces the seizure frequency. We assessed the effect
Alfred Dusabimana, Solomon Tsebeni Wafula, Stephen Jada Raimon, Joseph Nelson Siewe Fodjo, Dan Bhwana, Floribert Tepage, Gasim Abd-Elfarag, An Hotterbeekx, Steven Abrams, Robert Colebunders   +9 more
doaj   +1 more source

RETRACTED: Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways

Pharmacology Research & Perspectives, 2022
Advanced hepatocellular carcinoma (HCC) results in generally poor clinical outcomes and necessitates better therapeutic strategies. Ivermectin, which is an existing anti‐parasitic drug, has been recently identified as a novel anti‐cancer drug.
Haofeng Lu, Lin Zhou, Hongping Zuo, Wenjin Le, Jianfei Hu, Tiequan Zhang, Mi Li, Yufeng Yuan   +7 more
doaj   +1 more source

Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode.

PLoS Pathogens, 2022
The antiparasitic drug ivermectin plays an essential role in human and animal health globally. However, ivermectin resistance is widespread in veterinary helminths and there are growing concerns of sub-optimal responses to treatment in related helminths ...
Roz Laing, Stephen R Doyle, Jennifer McIntyre, Kirsty Maitland, Alison Morrison, David J Bartley, Ray Kaplan, Umer Chaudhry, Neil Sargison, Andy Tait, James A Cotton, Collette Britton, Eileen Devaney   +12 more
doaj   +1 more source

Chromatographic Quantification of Ivermectin and Pranziquantel in the Tablets Using Stability Indicating RP-HPLC Method [PDF]

Pharmaceutical Sciences, 2019
Background: A new stability indicating RP-HPLC based assay method was developed to quantify ivermectin and praziquantel simultaneously and applied effectively to tablets.
Naga Venkata Suresh Kumar Devaka, Vallabhaneni Madhusudhan Rao   +1 more
doaj   +1 more source

Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s.

Parasites & Vectors, 2023
Background The effects of ivermectin (endectocide) on mosquito survival make it a potential new malaria vector control tool. The drug can be administered to mosquito disease vectors through blood hosts that include humans and livestock. Its increased use
Caroline Kiuru, Kelly Ominde, Martha Muturi, Lawrence Babu, Caroline Wanjiku, Carlos Chaccour, Marta Ferreira Maia   +6 more
doaj   +1 more source

Ivermectin susceptibility and sporontocidal effect in Greater Mekong Subregion Anopheles

Malaria Journal, 2017
Background Novel vector control methods that can directly target outdoor malaria transmission are urgently needed in the Greater Mekong Subregion (GMS) to accelerate malaria elimination and artemisinin resistance containment efforts. Ivermectin mass drug
Kevin C. Kobylinski, Ratawan Ubalee, Alongkot Ponlawat, Chanyapat Nitatsukprasert, Siriporn Phasomkulsolsil, Thanaporn Wattanakul, Joel Tarning, Kesara Na-Bangchang, Patrick W. McCardle, Silas A. Davidson, Jason H. Richardson   +10 more
doaj   +1 more source

Identification of the metabolites of ivermectin in humans

Pharmacology Research & Perspectives, 2021
Mass drug administration of ivermectin has been proposed as a possible malaria elimination tool. Ivermectin exhibits a mosquito‐lethal effect well beyond its biological half‐life, suggesting the presence of active slowly eliminated metabolites.
Phornpimon Tipthara, Kevin C. Kobylinski, Markus Godejohann, Borimas Hanboonkunupakarn, Alison Roth, John H. Adams, Nicholas J. White, Podjanee Jittamala, Nicholas P. J. Day, Joel Tarning   +9 more
doaj   +1 more source

Plasma pharmacokinetic profile of fluralaner (Bravecto™) and ivermectin following concurrent administration to dogs

Parasites & Vectors, 2015
Background Fluralaner is a novel systemic ectoparasiticide for dogs providing immediate and persistent flea, tick and mite control after a single oral dose.
Feli M. Walther, Mark J. Allan, Rainer KA Roepke   +2 more
doaj   +1 more source

Use of Ivermectin as a Potential Chemoprophylaxis for COVID-19 in Egypt: A Randomised Clinical Trial [PDF]

Journal of Clinical and Diagnostic Research, 2021
Introduction: The rate of secondary attacks of SARS-COV-2 is high among household close contacts. Social distancing, isolation and infection control measures are important for preventing exposure to infection, but insufficient.
Waheed M Shoumann, Abdelmonem Awad Hegazy, Ramadan M Nafae, Moustafa I Ragab, Saad R Samra, Dalia Anas Ibrahim, Tarek H AL-Mahrouky, Ashraf E Sileem   +7 more
doaj   +1 more source