Modelling the elimination of river blindness using long-term epidemiological and programmatic data from Mali and Senegal [PDF]
, 2017 The onchocerciasis transmission models EPIONCHO and ONCHOSIM have been independently developed and used to explore the feasibility of eliminating onchocerciasis from Africa with mass (annual or biannual) distribution of ivermectin within the timeframes ...
Basáñez, M-G +7 more
core +6 more sources
Acta Biochimica et Biophysica SinicaEsophageal squamous cell carcinoma (ESCC) is one of the most common forms of malignancy worldwide. However, there is currently a lack of effective chemotherapeutic drugs for ESCC.
Liu Huiyang +4 more
doaj +1 more source
Caenorhabditis elegans muscle Cys-loop receptors as novel targets of terpenoids with potential anthelmintic activity [PDF]
, 2019 The anthelmintic treatment of nematode infections remains the pillar of worm control in both human and veterinary medicine. Since control is threatened by the appearance of drug resistant nematodes, there is a need to develop novel compounds, among which
Bouzat, Cecilia Beatriz +2 more
core +1 more source
Presence of the ABCB1 (MDR1) deletion mutation causing ivermectin hypersensitivity in certain dog breeds in Belgium [PDF]
, 2009 Hypersensitivity to ivermectin and certain other drugs in Collies and related breeds is caused by a 4-base pair deletion mutation in the ABCB1 gene, better known as the MDR1 gene, encoding P-glycoprotein.
Daminet, Sylvie +9 more
core +2 more sources
Density dependence and the control of helminth parasites.
, 2006 1. The transient dynamics and stability of a population are determined by the interplay between species density, its spatial distribution and the positive and negative density-dependent processes regulating population growth. 2.
Basáñez, María-Gloria +2 more
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The therapeutic efficacy and macrofilaricidal activity of doxycycline for the treatment of river blindness [PDF]
, 2014 Background. Onchocerca volvulus and lymphatic filariae, causing river blindness and elephantiasis, depend on endosymbiotic Wolbachia bacteria for growth, development, fertility, and survival.
Achim Hoerauf +43 more
core +1 more source
On 'Analytical models for the patchy spread of plant disease'.
, 2003 Epidemiologists are interested in using models that incorporate the effects of clustering in the spatial pattern of disease on epidemic dynamics. Bolker (1999, Bull. Math. Biol.
Filipe, JAN, Gilligan, CA, Maule, MM
core +1 more source
International Journal of Medicine and Health Development, 2004 Aim: To elucidate the non-drug related factors involved in the unique actions of ivermectin and the disassociation between plasma ivermectin concentrations, the commencement of microfilaricidal effects and adverse events.
E N Shu, 0 E Onwujekwe, P 0 Okonkwo
doaj
Evidence against Wolbachia symbiosis in Loa loa [PDF]
, 2003 BACKGROUND: The majority of filarial nematode species are host to Wolbachia bacterial endosymbionts, although a few including Acanthocheilonema viteae, Onchocerca flexuosa and Setaria equina have been shown to be free of infection. Comparisons of species
Akue, Jean-Paul +10 more
core +2 more sources
Pharmacokinetics, safety, and efficacy of a single co-administered dose of diethylcarbamazine, albendazole and ivermectin in adults with and without Wuchereria bancrofti infection in Cote d\u27Ivoire [PDF]
, 2019 BackgroundA single co-administered dose of ivermectin (IVM) plus diethylcarbamazine (DEC) plus albendazole (ALB), or triple-drug therapy, was recently found to be more effective for clearing microfilariae (Mf) than standard DEC plus ALB currently used ...
Bjerum, Catherine M +9 more
core +3 more sources