Results 21 to 30 of about 25,487 (235)

Prediction of potential inhibitors for RNA-dependent RNA polymerase of SARS-CoV-2 using comprehensive drug repurposing and molecular docking approach [PDF]

International Journal of Biological Macromolecules 163 (2020) 1787-1797, 2020
The pandemic prevalence of COVID-19 has become a very serious global health issue. Scientists all over the world have been heavily invested in the discovery of a drug to combat SARS-CoV-2. It has been found that RNA-dependent RNA Polymerase (RdRp) plays a crucial role in SARS-CoV-2 replication, and thus could be a potential drug target.
arxiv   +1 more source

Transcriptomic analyses implicate neuronal plasticity and chloride homeostasis in ivermectin resistance and response to treatment in a parasitic nematode.

PLoS Pathogens, 2022
The antiparasitic drug ivermectin plays an essential role in human and animal health globally. However, ivermectin resistance is widespread in veterinary helminths and there are growing concerns of sub-optimal responses to treatment in related helminths ...
Roz Laing, Stephen R Doyle, Jennifer McIntyre, Kirsty Maitland, Alison Morrison, David J Bartley, Ray Kaplan, Umer Chaudhry, Neil Sargison, Andy Tait, James A Cotton, Collette Britton, Eileen Devaney   +12 more
doaj   +1 more source

Ivermectin and malaria control [PDF]

Malaria Journal, 2017
As the world begins to realize the very real prospect of eliminating malaria as a public health problem globally, the scientific community is acutely aware that novel and innovative new tools will be required if that lofty goal is to be accomplished.
Satoshi Ōmura, Andy Crump
openaire   +4 more sources

Effect of Ivermectin Treatment on the Frequency of Seizures in Persons with Epilepsy Infected with Onchocerca volvulus

Pathogens, 2020
A clinical trial performed in the Democratic Republic of Congo (DRC), among persons with epilepsy (PWE) infected with Onchocerca volvulus treated with anti-seizure medication suggested that ivermectin reduces the seizure frequency. We assessed the effect
Alfred Dusabimana, Solomon Tsebeni Wafula, Stephen Jada Raimon, Joseph Nelson Siewe Fodjo, Dan Bhwana, Floribert Tepage, Gasim Abd-Elfarag, An Hotterbeekx, Steven Abrams, Robert Colebunders   +9 more
doaj   +1 more source

Effects of larval exposure to sublethal doses of ivermectin on adult fitness and susceptibility to ivermectin in Anopheles gambiae s.s.

Parasites & Vectors, 2023
Background The effects of ivermectin (endectocide) on mosquito survival make it a potential new malaria vector control tool. The drug can be administered to mosquito disease vectors through blood hosts that include humans and livestock. Its increased use
Caroline Kiuru, Kelly Ominde, Martha Muturi, Lawrence Babu, Caroline Wanjiku, Carlos Chaccour, Marta Ferreira Maia   +6 more
doaj   +1 more source

Ivermectin synergizes sorafenib in hepatocellular carcinoma via targeting multiple oncogenic pathways

Pharmacology Research & Perspectives, 2022
Advanced hepatocellular carcinoma (HCC) results in generally poor clinical outcomes and necessitates better therapeutic strategies. Ivermectin, which is an existing anti‐parasitic drug, has been recently identified as a novel anti‐cancer drug.
Haofeng Lu, Lin Zhou, Hongping Zuo, Wenjin Le, Jianfei Hu, Tiequan Zhang, Mi Li, Yufeng Yuan   +7 more
doaj   +1 more source

Ivermectin exposures reported to the Poisons Information Helpline in South Africa during the COVID-19 pandemic

South African Medical Journal, 2022
Background. Ivermectin is an antiparasitic drug that has shown in vitro activity against COVID‑19. Clinical studies supporting ivermectin for COVID‑19 prevention and treatment are conflicting, with important limitations. Public support for ivermectin is
V Pillay-Fuentes Lorente, G Voigt, C E du Plessis, K Balme, C J Marks, E H Decloedt, C Stephen, H Reuter, R van Rensburg   +8 more
doaj   +1 more source

Ivermectin susceptibility and sporontocidal effect in Greater Mekong Subregion Anopheles

Malaria Journal, 2017
Background Novel vector control methods that can directly target outdoor malaria transmission are urgently needed in the Greater Mekong Subregion (GMS) to accelerate malaria elimination and artemisinin resistance containment efforts. Ivermectin mass drug
Kevin C. Kobylinski, Ratawan Ubalee, Alongkot Ponlawat, Chanyapat Nitatsukprasert, Siriporn Phasomkulsolsil, Thanaporn Wattanakul, Joel Tarning, Kesara Na-Bangchang, Patrick W. McCardle, Silas A. Davidson, Jason H. Richardson   +10 more
doaj   +1 more source

Ivermectin susceptibility, sporontocidal effect, and inhibition of time to re-feed in the Amazonian malaria vector Anopheles darlingi

Malaria Journal, 2017
Background Outdoor malaria transmission hinders malaria elimination efforts in the Amazon region and novel vector control tools are needed. Ivermectin mass drug administration (MDA) to humans kills wild Anopheles, targets outdoor-feeding vectors, and can
Kevin C. Kobylinski, Karín S. Escobedo-Vargas, Victor M. López-Sifuentes, Salomón Durand, Edward S. Smith, G. Christian Baldeviano, Robert V. Gerbasi, Sara-Blythe Ballard, Craig A. Stoops, Gissella M. Vásquez   +9 more
doaj   +1 more source

Bayesian hypothesis testing and hierarchical modelling of ivermectin effectiveness in treating Covid-19 [PDF]

arXiv, 2021
Ivermectin is an antiparasitic drug that some have claimed is an effective treatment for reducing Covid-19 deaths. To test this claim, two recent peer reviewed papers both conducted a meta-analysis on a similar set of randomized controlled trials data, applying the same classical statistical approach.
arxiv