Results 41 to 50 of about 50,912 (262)

Human myiasis in Ecuador. [PDF]

, 2020
We review epidemiological and clinical data on human myiasis from Ecuador, based on data from the Ministry of Public Health (MPH) and a review of the available literature for clinical cases.
Calvopina, M, Castañeda, B, Cooper, PJ, Cueva, I, Ortiz-Prado, E, Rodriguez-Hidalgo, R   +5 more
core   +1 more source

Molecular mechanisms of Cys-loop ion channel receptor modulation by ivermectin

Frontiers in Molecular Neuroscience, 2012
Ivermectin is a gold standard anthelmintic drug that works by potently depressing neuronal activity and muscular contractility in arthropods and nematodes. At the molecular level, ivermectin activates inhibitory glutamate-gated chloride channels (GluClRs)
Timothy eLynagh, Joe eLynch
doaj   +1 more source

How can onchocerciasis elimination in Africa be accelerated? Modelling the impact of increased ivermectin treatment frequency and complementary vector control [PDF]

, 2017
Background: Great strides have been made toward onchocerciasis elimination by mass drug administration (MDA) of ivermectin. Focusing on MDA-eligible areas, we investigated where the elimination goal can be achieved by 2025 by continuation of current ...
Afework H Tekle, Alley, Annette C Kuesel, Basáñez, Basáñez, Basáñez, Bottomley, Boussinesq, Coffeng, Coffeng, Coffeng, Colebunders, Daniel A Boakye, Dyson, Filipe, GBD 2016 Disease and Injury Incidence and Prevalence Collaborators, Grace Fobi, Habbema, Honorat G M Zouré, Kaiser, Kamgno, Katabarwa, Kim, Little, Lont, Maria-Gloria Basáñez, Martin Walker, Matthews, Michel Boussinesq, Opoku, Plaisier, Plaisier, Plaisier, Sake J de Vlas, Samuel Wanji, Stolk, Stolk, Suzanne Verver, Tekle, Tekle, Traore, Turner, Turner, Turner, Turner, Walker, Walker, Walker, Walker, Wilma A Stolk, World Health Organization, World Health Organization, World Health Organization/African Programme for Onchocerciasis Control, World Health Organization/African Programme for Onchocerciasis Control, World Health Organization/African Programme for Onchocerciasis Control, World Health Organization/African Programme for Onchocerciasis Control, World Health Organization/African Programme for Onchocerciasis Control, Young Eun Kim, Zouré, Zouré   +59 more
core   +3 more sources

Impact of ivermectin components on Anopheles dirus and Anopheles minimus mosquito survival

Parasites & Vectors
Background Ivermectin mass drug administration to humans or livestock is a potential vector control tool for malaria elimination. Racemic ivermectin is composed of two components, namely a major component (> 80%; ivermectin B1a), which has an ethyl group
Pattarapon Khemrattrakool, Thitipong Hongsuwong, Phornpimon Tipthara, Rattawan Kullasakboonsri, Theerawit Phanphoowong, Patchara Sriwichai, Borimas Hanboonkunupakarn, Podjanee Jittamala, Joel Tarning, Kevin C. Kobylinski   +9 more
doaj   +1 more source

Targeting JAK‐1 in Disseminated Cutaneous Lichen Planus

JEADV Clinical Practice, EarlyView.
ABSTRACT We report the case of a 63‐year‐old woman with an exuberant and recalcitrant clinical presentation of LP who had an excellent response to 200 mg/day abrocitinib, a JAK‐1 inhibitor, after failure to other commonly used therapies. The efficacy of JAK inhibitors in lichen planus is supported by small case series and isolated case reports. Further
F. Barbosa, L. Siems, D. Luz, A. Duarte
wiley   +1 more source

Would ivermectin for malaria control be beneficial in onchocerciasis-endemic regions?

Infectious Diseases of Poverty, 2019
Background There is accumulating evidence supporting the use of ivermectin as a malaria control tool. Recent findings from the repeat ivermectin mass drug administrations for control of malaria trial demonstrated a reduced incidence of malaria in ...
Joseph Nelson Siewe Fodjo, Marina Kugler, An Hotterbeekx, Adam Hendy, Jean-Pierre Van Geertruyden, Robert Colebunders   +5 more
doaj   +1 more source

Ivermectin has New Application in Inhibiting Colorectal Cancer Cell Growth

Frontiers in Pharmacology, 2021
Colorectal cancer (CRC) is the third most common cancer worldwide and still lacks effective therapy. Ivermectin, an antiparasitic drug, has been shown to possess anti-inflammation, anti-virus, and antitumor properties. However, whether ivermectin affects
Shican Zhou, Hang Wu, Wenjuan Ning, Xiao Wu, Xiaoxiao Xu, Yuanqiao Ma, Xingwang Li, Junhong Hu, Chenyu Wang, Junpeng Wang   +9 more
doaj   +1 more source

Advancing pharmacometrics in Africa—Transition from capacity development toward job creation

CPT: Pharmacometrics &Systems Pharmacology, Volume 14, Issue 3, Page 407-419, March 2025.
Abstract Trained pharmacometricians remain scarce in Africa due to limited training opportunities, lack of a pharmaceutical product development ecosystem, and emigration to high‐income countries. The Applied Pharmacometrics Training (APT) fellowship program was established to address these gaps and specifically foster job creation for talent retention.
Goonaseelan (Colin) Pillai, Samer Mouksassi, Innocent G. Asiimwe, Craig R. Rayner, Steven Kern, Phumla Sinxadi, Paolo Denti, Eric Decloedt, Catriona Waitt, Bernhards R. Ogutu, Rik de Greef   +10 more
wiley   +1 more source

Analysis of putative resistance gene loci in UK field populations of Haemonchus contortus after six years of macrocyclic lactone use [PDF]

, 2016
Sheep farmers in the UK rely on strategic anthelmintic use to treat and control gastrointestinal roundworms in their flocks. However, resistance to these drugs is now widespread and threatens the sustainability of sheep production.
Devaney, Eileen, Laing, Roz, Lecova, Lenka, Maitland, Kirsty, Skuce, Philip J., Tait, Andy   +5 more
core   +1 more source

Equine fasciolosis due to Fasciola hepatica in the Community of Madrid (Spain): First report of a rare parasitic infection in horses

Veterinary Record Case Reports, EarlyView.
Abstract We reported for the first time a confirmed case of equine fasciolosis in the Community of Madrid (Spain). Here, we described the clinical presentation, diagnostic approach and treatment of the affected horse, as well as the seroprevalence of Fasciola hepatica in the equestrian centre where it was detected.
Carolina R. Sanz, Juan David Carbonell, Guadalupe Miró, Arancha Meana   +3 more
wiley   +1 more source