Results 61 to 70 of about 46,297 (216)

Development of an in vitro drug sensitivity assay for Trichuris muris first-stage larvae [PDF]

, 2013
Trichuriasis represents a major public health problem in the developing world and is regarded as a neglected disease. Albendazole and mebendazole, the two drugs of choice against trichuriasis display only moderate cure rates, hence alternative drugs are ...
Keiser, Jennifer, Tritten, Lucienne, Wimmersberger, David   +2 more
core   +2 more sources

Functional characterization of ivermectin binding sites in α1β2γ2L GABA(A) receptors

Frontiers in Molecular Neuroscience, 2015
GABAA receptors (GABAARs) are the major inhibitory neurotransmitter receptors in the brain and are therapeutic targets for many indications including sedation, anesthesia and anxiolysis.
Argel eEstrada, Joe eLynch
doaj   +1 more source

Short Term Effect of Ivermectin on the Bacterial Microbiota from Fecal Samples in Chinchillas (Chinchilla lanigera)

Veterinary Sciences, 2023
The gastrointestinal microbiota plays an important role in health of the host animals and the detrimental influence of pharmaceutical treatment on the fecal microbiota receives an increasing concern.
Xinyi Ma, Jing Li, Luo Yang, Haoqian Liu, Yiping Zhu, Honglin Ren, Feng Yu, Bo Liu   +7 more
doaj   +1 more source

An empirical method to estimate the effect of soil on the rate for transmission of damping‐off disease

, 2004
The ability of some soils to suppress soil-borne diseases has been long recognised, but the underlying epidemiological mechanisms by which this occurs are largely unknown.• Using damping-off disease caused by Rhizoctonia solani, spreading through ...
Alabouvette C, Bailey DJ, C. A. Gilligan, Cook RJ, Dwyer G, Garrett KA, Gilligan CA, Gilligan CA, Gilligan CA, Hoper H, J. A. N. Filipe, Jeger MJ, Kleczkowski A, Nisbet RM, Otten W, Pielaat A, van den Bosch F, Van der Plank JE, W. Otten, Whipps JM   +19 more
core   +1 more source

A mixed methods approach to evaluating community drug distributor performance in the control of neglected tropical diseases [PDF]

, 2016
BACKGROUND: Trusted literate, or semi-literate, community drug distributors (CDDs) are the primary implementers in integrated preventive chemotherapy (IPC) programmes for Neglected Tropical Disease (NTD) control.
A Wallace, AW Solomon, C Hanson, D Evans, EC Emukah, Fiona M. Fleming, FM Fleming, Fred Matovu, J Green, J Leslie, JA Wright, JC Okeibunor, JC Okeibunor, JH Kolaczinski, JH Kolaczinski, Joanne P. Webster, JS Dill, K Banek, KA Grepin, KL Leonard, Kristian S. Hansen, L Nkonki, M Callaghan, MA Bruijnzeels, MC Baker, MF Drummond, Ministry of Health, MN Katabarwa, MO Omedo, N Najnin, P Agyei-Baffour, P Akweongo, P Basinga, SC Francis, TK Ryman, UV Amazigo, V Wiseman, World Health Organisation, World Health Organisation, World Health Organization   +39 more
core   +3 more sources

Physiological and behavioural effects of continuous remifentanil‐xylazine administration in donkeys

Equine Veterinary Journal, EarlyView.
Abstract Background Remifentanil and xylazine are used as continuous infusions to facilitate standing surgery in horses. Their use for this purpose has not been reported in donkeys. Objectives To evaluate the behavioural, sedative, and cardiorespiratory effects of continuous intravenous infusion of remifentanil and xylazine in donkeys. Study Design Non‐
Kássia Fernanda Araújo Damasceno, Andressa Nunes Mouta, Larissa de Sant' Ana Alves, Kathryn Nóbrega Arcoverde, Herbert Reis Aragão, Jerson Marques Cavalcante, Valéria Veras de Paula   +6 more
wiley   +1 more source

Early-life exposure to Ivermectin alters long-term growth and disease susceptibility.

PLoS ONE, 2021
Ivermectin is a broad-spectrum antiparasitic medicine, which is often used as a treatment for parasites or as a prophylaxis. While studies have looked at the long-term effects of Ivermectin on helminths, studies have not considered the long-term impacts ...
Taegan A McMahon, Shannon Fernandez-Denmark, Jeffrey M Grim   +2 more
doaj   +1 more source

Genomic introgression mapping of field-derived multiple-anthelmintic resistance in Teladorsagia circumcincta [PDF]

, 2017
Preventive chemotherapy has long been practiced against nematode parasites of livestock, leading to widespread drug resistance, and is increasingly being adopted for eradication of human parasitic nematodes even though it is similarly likely to lead to ...
Bisset, Stewart A, Choi, Young-Jun, Doyle, Stephen R, Grant, Warwick N, Hallsworth-Pepin, Kymberlie, Martin, John, Mitreva, Makedonka   +6 more
core   +4 more sources

A mini‐review of chronic suppression of the hypothalamic–pituitary–adrenal axis in animals with P‐glycoprotein deficiency

Journal of Small Animal Practice, EarlyView.
This mini‐review describes the pathophysiology of the disrupted hypothalamic–pituitary–adrenal axis in dogs, and probably cats, with the MDR1 (ABCB1) mutation, ABCB1‐1Δ in dogs and ABCB11930‐1931del TC in cats. Clinical consequences in affected animals are discussed and therapeutic interventions to consider are presented.
K. L. Mealey
wiley   +1 more source

Evaluation of in vitro drug-drug interactions of ivermectin and antimalarial compounds

Malaria Journal
Background Ivermectin is lethal to Anopheles mosquitoes and a novel approach to malaria transmission control. Ivermectin could be co-administered with antimalarial drugs in mass drug administration, seasonal malaria chemoprevention, or other ...
Phornpimon Tipthara, Rattawan Kullasakboonsri, Kevin C. Kobylinski, Joel Tarning   +3 more
doaj   +1 more source