Results 61 to 70 of about 20,113 (176)

Impact of a Research Integrity Assessment (RIA) of Randomized Controlled Trials Included in Interventional COVID‐19 Systematic Reviews: A Meta‐Epidemiological Study

open access: yesCochrane Evidence Synthesis and Methods, Volume 4, Issue 2, March 2026.
ABSTRACT Objective This study aimed to evaluate the feasibility, reliability, and impact of the Research Integrity Assessment (RIA) tool when applied to randomized controlled trials (RCTs) included in systematic reviews. RIA is a structured tool designed to assess retractions, trial registration, ethical approval, authorship, and plausibility of ...
Stephanie Weibel   +12 more
wiley   +1 more source

Trends and Patterns of Adverse Drug Reaction Reporting in Sierra Leone: A Retrospective Analysis of VigiFlow Data (2008–2022)

open access: yesPharmacoepidemiology and Drug Safety, Volume 35, Issue 3, March 2026.
ABSTRACT Purpose Adverse drug reactions (ADRs) present significant obstacles for healthcare systems, impacting both patient safety and the effectiveness of treatments. Despite this, there is a scarcity of research on ADR reports in Sierra Leone, especially over long periods.
Isatu Jalloh   +4 more
wiley   +1 more source

Ivermectin: Difficulties in resolving pharmacokinetic and pharmacodynamic relationships in onchocerciasis

open access: yesInternational Journal of Medicine and Health Development, 2004
Aim: To elucidate the non-drug related factors involved in the unique actions of ivermectin and the disassociation between plasma ivermectin concentrations, the commencement of microfilaricidal effects and adverse events.
E N Shu, 0 E Onwujekwe, P 0 Okonkwo
doaj  

Ivermectin inhibits the growth of ESCC by activating the ATF4-mediated endoplasmic reticulum stress-autophagy pathway

open access: yesActa Biochimica et Biophysica Sinica
Esophageal squamous cell carcinoma (ESCC) is one of the most common forms of malignancy worldwide. However, there is currently a lack of effective chemotherapeutic drugs for ESCC.
Liu Huiyang   +4 more
doaj   +1 more source

The Impact of Study Size on COVID‐19 Treatment Outcomes: A Meta‐Epidemiological Study Comparing Large and Small Randomized Controlled Trials

open access: yesReviews in Medical Virology, Volume 36, Issue 2, March 2026.
ABSTRACT Small randomized controlled trials (RCTs) in COVID‐19 meta‐analyses have been associated with more favourable treatment effects and reduced result stability. This study assessed how trial size impacts effect estimates, statistical stability, and risk of bias.
Dong Hyun Kim   +11 more
wiley   +1 more source

Investigated Different Ratios of Cotton Seed Cake With Dried Sesbania sesban Leaves on the Feed Intake, Digestibility and Growth Performance of Semien Sheep

open access: yesVeterinary Medicine and Science, Volume 12, Issue 2, March 2026.
The price of feed cost is one of the main challenges for animal producers in Ethiopia. Sesbania is not utilized for animal feed and is commonly found in different geographical locations. Therefore, mixing of cotton seed cake with dried Sesbania sesban leaves at equal proportion improves biological performance of Semien sheep and economically visible ...
Wondimu Demoz Tessema   +2 more
wiley   +1 more source

Enhanced detection of equine strongyles: Insights from morphological and nemabiome metabarcoding approaches in northern Iran

open access: yesEquine Veterinary Journal, Volume 58, Issue 2, Page 508-522, March 2026.
Abstract Background Strongyles pose significant health concerns for equids globally. Strongyles, comprising over 60 species, can lead to severe morbidity and mortality, with Strongylus vulgaris posing higher risks due to its migratory behaviour. Routine diagnostic methods, such as faecal egg counts, lack species‐level resolution, while traditional ...
Sina Mohtasebi   +5 more
wiley   +1 more source

Effect of land use change on Melolonthidae (Coleoptera: Scarabaeoidea) beetle communities in the deforestation arc of the Brazilian Amazon

open access: yesInsect Conservation and Diversity, Volume 19, Issue 2, Page 404-419, March 2026.
Habitat transformation in Amazon due to agriculture expansion impairs Melolonthidae diversity. Assemblage response towards habitat transformation are group‐dependent. Although highly disturbed, Amazon arc of deforestation region dwells sensitive insect assemblages. Abstract Although the Amazon provides crucial goods and ecosystem services for humanity,
Kleyton Rezende Ferreira   +4 more
wiley   +1 more source

The exposomal imprint on rosacea: More than skin deep

open access: yesJournal of the European Academy of Dermatology and Venereology, Volume 40, Issue 3, Page 387-403, March 2026.
Rosacea reflects systemic and environmental interactions, not just a skin disorder. Key factors include environmental triggers, genetic and microbiome influences, diagnostic gaps in skin of colour and social determinants. Advances in multi‐omics and exposome integration highlight pathways towards precision medicine, prevention and equitable, patient ...
Katerina Grafanaki   +3 more
wiley   +1 more source

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