Results 131 to 140 of about 1,005 (158)
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IVIVC of Octreotide in PLGA-Glucose Microsphere Formulation, Sandostatin® LAR
AAPS PharmSciTech, 2022In vitro-in vivo correlation (IVIVC) analysis reveals a relationship between in vitro release and in vivo pharmacokinetic response of the drug of interest. Sandostatin LAR Depot (SLD) for endocrine tumors and acromegaly is a sustained-release formulation of octreotide, a cyclic oligomer of 8 amino acids, which prolongs therapeutic efficacy and enhances
Jin-Sook, Song +5 more
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Integrating drug permeability with dissolution profile to develop IVIVC
Biopharmaceutics & Drug Disposition, 2012ABSTRACTIn this review article, three different approaches to predict in vivo oral absorption based on the in vitro data of drug permeability, solubility and dissolution were introduced. At the drug discovery stage, the absorption potential of each candidate is most important to select better compounds for further development.
Ryusuke, Takano +2 more
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Extrahepatic Metabolism may Complicate the IVIVC in Rats
Drug Metabolism Letters, 2014As the liver is generally considered the organ most involved in metabolic transformations, metabolism in other organs is often overlooked and in vitro screening systems largely adopted in drug discovery are generally based on liver tissue fractions. First pharmacokinetics of new chemical entities (NCEs) are initially based on preclinical species; rat ...
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IVIVC: Indices for Comparing Release and Response Profiles
Drug Development and Industrial Pharmacy, 1999An important aspect of in vivo–in vitro correlation (IVIVC) is to quantify the difference between two time profiles, typically from a reference formulation R and a test formulation T.
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Transdermal Delivery of Etoposide Phosphate II: In Vitro In Vivo Correlations (IVIVC)
Journal of Pharmaceutical Sciences, 2016A dependable in vitro in vivo correlation (IVIVC) is a vital tool to optimize drug formulation and expedite product development time. Although many IVIVC examples are available for oral delivery systems, IVIVC for transdermal delivery is far less common, especially for electrical-assisted delivery.
Hiren Patel +2 more
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Application of an NLME–Stochastic Deconvolution Approach to Level A IVIVC Modeling
Journal of Pharmaceutical Sciences, 2017Stochastic deconvolution is a parameter estimation method that calculates drug absorption using a nonlinear mixed-effects model in which the random effects associated with absorption represent a Wiener process. The present work compares (1) stochastic deconvolution and (2) numerical deconvolution, using clinical pharmacokinetic (PK) data generated for ...
Maziar, Kakhi +3 more
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In Vivo–In Vitro Correlation (IVIVC) Modeling Incorporating a Convolution Step
Journal of Pharmacokinetics and Pharmacodynamics, 2001The purpose of in vivo-in vitro correlation (IVIVC) modeling is described. These models are usually fitted to deconvoluted data rather than the raw plasma drug concentration/time data. Such a two-stage analysis is undesirable because the deconvolution step is unstable and because the fitted model predicts the fraction of a dosage unit dissolved ...
T, O'Hara +5 more
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IN VITRO-IN VIVO CORRELATION (IVIVC): TAMOXIFEN NANOSPHERES
INDIAN DRUGSThe primary goal of this study was to establish an in vitro-in vivo correlation (IVIVC) for tamoxifen (TAM)- loaded polycaprolactone-chitosan nanospheres. The plasma attention of TAM and time records have been used to calculate the pharmacokinetic parameters.
Phalguna Yadagiri, Michael Wombeogo
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The Role of in Vitro-in Vivo Correlations (IVIVC) to Regulatory Agencies
1997Dissolution testing remains a potentially powerful and nearly always useful method for obtaining data related to quality and, potentially, clinical performance of dosage forms, especially solid oral dosage forms. But, not surprisingly, dissolution is not always a surrogate for bioequivalence, which necessitates human testing for determination of ...
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In Vitro Dissolution as a Tool for Formulation Selection: Telmisartan Two-Step IVIVC
Molecular Pharmaceutics, 2018The purpose of this investigation was to develop an exploratory two-step level A IVIVC for three telmisartan oral immediate release formulations, the reference product Micardis, and two generic formulations (X1 and X2). Correlation was validated with a third test formulation, Y1.
Alejandro Ruiz Picazo +8 more
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