Results 211 to 220 of about 2,161,678 (248)
The JAK-STAT Signaling Pathway in Epilepsy
Current Neuropharmacology, 2023 Abstract: Epilepsy is defined as spontaneous recurrent seizures in the brain. There is increasing evidence that inflammatory mediators and immune cells are involved in epileptic seizures. As more research is done on inflammatory factors and immune cells in epilepsy, new targets for the treatment of epilepsy will be revealed.
Jia-Ai Li, Di Ma, Hongmei Meng
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The JAK/STAT signaling pathway: from bench to clinic [PDF]
Signal Transduction and Targeted Therapy, 2021 AbstractThe Janus kinase/signal transducer and activator of transcription (JAK/STAT) signaling pathway was discovered more than a quarter-century ago. As a fulcrum of many vital cellular processes, the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and ...
Xia Zhao, Xiaoyi Hu
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International Journal of Molecular Sciences, 2023 Hepatocellular Carcinoma (HCC) continues to pose a substantial global health challenge due to its high incidence and limited therapeutic options. In recent years, the Janus Kinase (JAK) and Signal Transducer and Activator of Transcription (STAT) pathway ...
Hyuk Moon, Simon Weonsang Ro
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Targeting the JAK/STAT Signaling Pathway for Breast Cancer
Current Medicinal Chemistry, 2021Breast cancer is the most common malignant tumor in women worldwide. Traditional ways of treatment, including radiotherapy and endocrine therapy, for breast cancer have inevitable side effects. In recent decades, targeted therapies for breast cancer have rapidly advanced and shown a promising future.
Fei Shao, Xiaonan Pang, Gyeong Hun Baeg
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Pharmacological Effects of Polyphenol Phytochemicals on the JAK-STAT Signaling Pathway [PDF]
Frontiers in Pharmacology, 2021 The JAK-STAT signaling pathway is a common pathway of many cytokine signal transductions, closely related to cell proliferation, apoptosis, differentiation, and inflammatory response. It is essential for inhibiting the inflammatory response, initiating innate immunity, and coordinating adaptive immune mechanisms. Owing to the nature of this pathway and
Daquan Chen, Wenwei Zhu
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Evolving cognition of the JAK-STAT signaling pathway: autoimmune disorders and cancer
Signal Transduction and Targeted Therapy, 2023 The Janus kinase (JAK) signal transducer and activator of transcription (JAK-STAT) pathway is an evolutionarily conserved mechanism of transmembrane signal transduction that enables cells to communicate with the exterior environment.
Li Lanjuan, Xinyu Gu, Qingmiao Shi
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JAK-STAT signaling pathway in non-infectious uveitis
Biochemical Pharmacology, 2022Non-infectious uveitis (NIU) refers to various intraocular inflammatory disorders responsible for severe visual loss. Cytokines participate in the regulation of ocular homeostasis and NIU pathological processes. Cytokine receptors transmit signals by activating Janus kinase (JAK) and signal transducer and activator of transcription (STAT) proteins ...
Yuhan, Su +3 more
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The role of JAK/STAT signaling pathway and its inhibitors in diseases
International Immunopharmacology, 2020The JAK/STAT signaling pathway is an universally expressed intracellular signal transduction pathway and involved in many crucial biological processes, including cell proliferation, differentiation, apoptosis, and immune regulation. It provides a direct mechanism for extracellular factors-regulated gene expression.
Shuang Liu, Youzhi Wang
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Signalling through the JAK–STAT pathway in the developing brain
Trends in Neurosciences, 1999The JAK -STAT (Janus kinase-signal transducer and activator of transcription) signalling pathway that is stimulated by cytokines has been much investigated in haematopoietic cells, but recent data indicate that this pathway is also present and active during neuronal and glial differentiation.
Cattaneo E, Conti, Luciano, De Fraja C.
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A CK2-dependent mechanism for activation of the JAK-STAT signaling pathway [PDF]
Blood, 2011 AbstractJAK-STAT signaling is involved in the regulation of cell survival, proliferation, and differentiation. JAK tyrosine kinases can be transiently activated by cytokines or growth factors in normal cells, whereas they become constitutively activated as a result of mutations that affect their function in tumors.
Luqin Deng +2 more
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