Results 221 to 230 of about 2,161,678 (248)

Role of the JAK/STAT signaling pathway in diabetic nephropathy

American Journal of Physiology-Renal Physiology, 2006
Excessive cellular growth is a major contributor to pathological changes associated with diabetic nephropathy. In particular, high glucose-induced growth of glomerular mesangial cells is a characteristic feature of diabetes-induced renal complications. Glomerular mesangial cells respond to traditional growth factors, although in diabetes this occurs in
Mario B, Marrero, Amy K, Banes-Berceli, David M, Stern, Douglas C, Eaton   +3 more
openaire   +2 more sources

The Jak-Stat Pathway of Cytokine Signaling

2004
Hematopoiesis is defined by progressive changes in cytokine receptor expression and a delicate balance of intracellular activators and negative regulators of cytokine signaling. Binding of cytokines to their cognate receptors activates downstream signaling pathways and induces biologic responses. The plethora of cytokines that exhibit common structural
Ben A. Croker, Nicos A. Nicola
openaire   +1 more source

The Specific Roles of JAK/STAT Signaling Pathway in Sepsis

Inflammation, 2015
The Janus kinase-signal transducer and activator of transcription (JAK/STAT) pathway is a principal signaling pathway for the signal transduction of many pivotal cytokines involved in sepsis. Binding of cytokines to corresponding receptors can activate associated JAK kinases, which selectively phosphorylate STATs.
Bin, Cai, Jian-ping, Cai, Yu-long, Luo, Cheng, Chen, Sen, Zhang   +4 more
exaly   +3 more sources

Biological functions of Jak/Stat signaling pathway in Drosophila

Russian Journal of Genetics, 2013
The basic biological processes under the control of the Jak/Stat signaling pathway in Drosophila are reviewed. As shown, the fruit fly Drosophila melanogaster is a very convenient model organism for investigation of Jak/Stat functions in various aspects of ontogenesis.
L A, Lebedeva, A V, Shaposhnikov, V V, Panov, Y V, Shidlovskii   +3 more
openaire   +2 more sources

Role of JAK-STAT Pathway in Cancer Signaling

2018
The JAK-STAT pathway plays a central role in cell proliferation, differentiation, survival, and embryological processes. Aberrant activation of the JAK-STAT pathway due to genetic mutations, amplifications, or polymorphisms can lead to constitutive or persistent activation of the pathway and affect the development of some cancers.
Na Luo, Justin M. Balko
openaire   +1 more source

Regulation of the Jak/STAT signalling pathway

Cellular Signalling, 1995
D S, Finbloom, A C, Larner
openaire   +2 more sources

The Jak-Stat Pathway: Cytokine Signalling from the Receptor to the Nucleus

Journal of Receptors and Signal Transduction, 1999
The Jak-STAT pathway was originally discovered through the study of interferon induced intracellular signal transduction. Meanwhile, a large number of cytokines, hormones and growth factors have been found to activate Jaks and STATs. Jaks (Janus Kinases) are a unique class of tyrosine kinases that associate with cytokine receptors. Upon ligand binding,
openaire   +3 more sources

JAK-STAT signaling pathway and rosacea

Chinese Journal of Dermatology, 2021
openaire   +1 more source

C-type lectin 5, a novel pattern recognition receptor for the JAK/STAT signaling pathway in

Journal of Invertebrate Pathology, 2021
Tao Geng, Huazhou Wu
exaly  

[Recent progresses in the JAK-STAT signaling pathways].

Nihon rinsho. Japanese journal of clinical medicine, 1998
The janus kinase(JAK) family and the signal transducer and activator of transcription (STAT) family members have been shown to be activated by a number of cytokines, growth factors and oncogenic tyrosine kinases, and called the JAK-STAT pathways collectively.
openaire   +1 more source