Results 51 to 60 of about 399,504 (355)

Development of an enzyme-coupled activity assay for Janus kinase 2 inhibitor screening

SLAS Discovery, 2023
JAK2 transmits signals of several important cytokines, such as growth hormone and erythropoietin. The interest toward the therapeutic targeting of JAK2 was boosted in 2005, when the somatic JAK2 V617F mutation, responsible for the majority of ...
Angelika Pölläniemi, Anniina Virtanen, Olli Silvennoinen, Teemu Haikarainen   +3 more
doaj   +1 more source

Alopecia areata: a multifactorial autoimmune condition [PDF]

, 2019
Alopecia areata is an autoimmune disease that results in non-scarring hair loss, and it is clinically characterised by small patches of baldness on the scalp and/or around the body. It can later progress to total loss of scalp hair (Alopecia totalis) and/
Butcher, John P., Henriquez, Fiona L., Reid, Stuart, Simakou, Teontor   +3 more
core   +1 more source

Janus kinase 2 variants associated with the transformation of myeloproliferative neoplasms into acute myeloid leukemia

Cancer, 2019
Canonical Janus kinase 2 (JAK2) V617F and exon 12 mutations in myeloid neoplasms are well described. There are limited reports of other JAK2 variants of potential clinical relevance.
C. Benton, P. Boddu, C. Dinardo, P. Bose, Feng Wang, R. Assi, N. Pemmaraju, Devendra Kc, S. Pierce, K. Patel, M. Konopleva, F. Ravandi, G. Garcia-Manero, T. Kadia, J. Cortes, H. Kantarjian, M. Andreeff, S. Verstovsek   +17 more
semanticscholar   +1 more source

Down syndrome-recent progress and future prospects [PDF]

, 2009
Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and is associated with a number of deleterious phenotypes, including learning disability, heart defects, early-onset Alzheimer's disease and childhood leukaemia.
Adams, Adayev, Ahn, Ait Yahya-Graison, Altafaj, Antonarakis, Arron, Aylward, Aylward, Bartel, Belichenko, Bercovich, Best, Bliss, Brault, Canfield, Canzonetta, Carothers, Clark, Contestabile, Costa, de Graaf, De Vita, Denoeud, Dowjat, Draheim, E. M.C. Fisher, Ermak, Ermak, F. K. Wiseman, Fernandez, Freeman, Fuentes, Gerstein, Glasson, Granholm, Granholm, Groet, Guidi, Gwack, Harashima, Hasle, Hassold, Hill, Holland, Holtzman, Holtzman, Hunter, Hunter, Izraeli, Janicki, Johannsen, K. A. Alford, Kiyoi, Klusmann, Kuhn, Lai, Lee, Liang, Loos, Lorenzi, Mart  nez de Lagr  n, Maslen, Meng, Moore, Morice, Morris, Morrison, Murthy, Necchi, Nistor, O'Doherty, O'Donovan, O'Nuallain, Olson, Park, Pearlson, Prandini, Richtsmeier, Ryoo, Sato, Seo, Sethupathy, Stefansson, Sultan, Sussan, Toso, Tybulewicz, V. L.J. Tybulewicz, Wahab, Walters, Wechsler, Wegiel, Weis, Williams, Woods, Yang   +96 more
core   +2 more sources

Discovery of Janus Kinase 2 (JAK2) and Histone Deacetylase (HDAC) Dual Inhibitors as a Novel Strategy for the Combinational Treatment of Leukemia and Invasive Fungal Infections.

Journal of Medicinal Chemistry, 2018
Clinically, leukemia patients often suffer from the limited efficacy of chemotherapy and high risks of infection by invasive fungal pathogens. Herein, a novel therapeutic strategy was developed in which a small molecule can simultaneously treat leukemia ...
Yahui Huang, Guoqiang Dong, Huanqiu Li, Na Liu, Wannian Zhang, C. Sheng   +5 more
semanticscholar   +1 more source

Intracellular mechanisms underlying the nicotinic enhancement of LTP in the rat dentate gyrus [PDF]

, 2008
We have previously shown that activation of nicotinic acetylcholine receptors (nAChRs) enhanced long-term potentiation (LTP) in the rat dentate gyrus in vitro via activation of α7 nAChR. In the present studies, mechanisms underlying the acute and chronic
Abel, Arendt, Atack, Bain, Bear, Blanquet, Bliss, Blitzer, Blitzer, Bogan, Casey, Charpantier, Cho, Dajas-Bailador, Davies, Davis, Decker, Dhavan, Dominguez del Toro, English, Faghih, Fujii, Giovannini, Gray, Hope, Huang, Huang, Hunter, Hurst, Ji, Jones, Kawakami, Kelly, Kihara, Klein, Krause, Le Novere, Levin, Li, Liston, Lu, Man, Mann, Marrero, Matsuyama, Matthies, Meriane, Opazo, O’Dell, Peavy, Picciotto, Polesskaya, Polesskaya, Radcliffe, Roberson, Rush, Salazar, Sanna, Sanna, Santos, Seguela, Sharifzadeh, Sharifzadeh, Sharma, Shaw, Shaw, Sweatt, Takada-Takatori, Tominaga-Yoshino, Wada, Wang, Wang, Welsby, Welsby, Whitehouse, Woo, Wu, Yang, Ying, Yu, Zhang, Zwart   +81 more
core   +1 more source

The helicase HAGE prevents interferon-a-induced PML expression in ABCB5+ malignant melanoma-initiating cells by promoting the expression of SOCS1 [PDF]

, 2014
The tumour suppressor PML (promyelocytic leukaemia protein) regulates several cellular pathways involving cell growth, apoptosis, differentiation and senescence.
A Carracedo, A Hauschild, A Jankowsky, A Kakizuka, AA Tarhini, AJ Linley, BJ Wilson, C Gurrieri, C Lavau, C Schindler, D Ungureanu, DJ Groskreutz, G Marie-Claude, GB Lesinski, H de The, J Borrow, K Ito, K Wheatley, M Stadler, MK Chelbi-Alix, NY Frank, O Cordin, P Salomoni, RAR Piganis, S Aaronson, T Kamura, T Regad, T Regad, T Regad, T Schatton, TA Endo, W Condemine, WB Dias, Z Li   +33 more
core   +1 more source

A case of new-onset vitiligo in a patient on tofacitinib and brief review of paradoxical presentations with other novel targeted therapies [PDF]

, 2020
With recent advancements in the understanding of vitiligo pathogenesis, Janus kinase (JAK) inhibitors have emerged as a promising new treatment modality, but their effects remain incompletely elucidated.
Alikhan, Mujahed, Jogi, Reena, Nguyen, Julie K, Patel, Anisha B, Schlichte, Megan J   +4 more
core  

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity [PDF]

, 2017
STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects.
De Bosscher, Karolien, De Cauwer, Lode, Icardi, Laura, Mori, Raffaele, Peelman, Frank, Tavernier, Jan, Van Der Heyden, José, Wauman, Joris   +7 more
core   +3 more sources

Leptin receptor signaling via Janus kinase 2/Signal transducer and activator of transcription 3 impacts on ovarian cancer cell phenotypes

OncoTarget, 2017
Ovarian cancer is a leading cause of cancer mortality in women world-wide. Considerable progress has been made to characterize the different subtypes of ovarian cancer, but specific therapies remain limited and prognosis poor.
J. Kumar, Hao Fang, D. McCulloch, T. Crowley, A. Ward   +4 more
semanticscholar   +1 more source