Results 81 to 90 of about 399,504 (355)
Haematologica, 2011 Background Prognostic risk stratification according to acquired or inherited genetic alterations has received increasing attention in acute myeloid leukemia in recent years.
Sarolta Nahajevszky +18 more
doaj +1 more source
Role of the bone morphogenic protein pathway in developmental haemopoiesis and leukaemogenesis [PDF]
, 2016 Myeloid leukaemias share the common characteristics of being stem cell-derived clonal diseases, characterised by excessive proliferation of one or more myeloid lineage.
Toofan, Parto, Wheadon, Helen
core +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Hepatology, EarlyView., 2022 Mesenchymal stem cells subset, educated by TNF‐α, are involved to generate inflammatory microenvironment and promote hepatocarcinogenesis Abstract Background and Aims Increasing evidence suggests that mesenchymal stem cells (MSCs) home to injured local tissues and the tumor microenvironment in the liver.
Chen Zong +9 more
wiley +1 more source
Hematology, 2022 Background: The V617F mutation of Janus-associated kinase 2 (JAK2) is common in myeloproliferative neoplasms (MPN). JAK2 V617F mutation can be detected in patients with de novo acute myeloid leukemia (AML), but de novo acute promyelocytic leukemia (APL ...
Yi-zhi Jiang +8 more
doaj +1 more source
Involvement of JAK2 and MAPK on type II nitric oxide synthase expression in skin-derived dendritic cells [PDF]
, 1999 In this report, we demonstrate that a fetal mouse skin-derived dendritic cell line produces nitric oxide (NO) in response to the endotoxin [lipopolysaccharide (LPS)] and to cytokines [tumor necrosis factor-alpha (TNF-alpha) and granulocyte-macrophage ...
Carvalho, AP +4 more
core +1 more source
Interferon-γ acutely augments inhibition of neocortical layer 5 pyramidal neurons [PDF]
, 2020 BACKGROUND: Interferon-γ (IFN-γ, a type II IFN) is present in the central nervous system (CNS) under various conditions. Evidence is emerging that, in addition to its immunological role, IFN-γ modulates neuronal morphology, function, and development in ...
Bräuer, Anja U. +7 more
core +1 more source
Selective Janus kinase inhibition preserves interferon-λ–mediated antiviral responses
Science immunology, 2021 TYK2 is required for efficient IFN-α/β signaling but dispensable for IFN-λ–mediated antiviral protection in epithelial cells. Specific inhibition Janus kinase (JAK) inhibitors are powerful therapeutics used to treat inflammatory diseases but are also ...
D. Schnepf +16 more
semanticscholar +1 more source
FEBS Open Bio, EarlyView.We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan +6 more
wiley +1 more source
Constitutive nuclear localization of Janus kinases 1 and 2. [PDF]
Endocrinology, 1996 Both GH and the GH receptor have been reported to undergo rapid nuclear translocation. Janus kinases (JAK) 1 and 2 have been implicated in GH receptor signaling, and both of these kinases are phosphorylated by GH stimulation. In this report, we have investigated the subcellular distribution of JAK1 and JAK2.
Lobie, P.E. +5 more
openaire +4 more sources