Results 11 to 20 of about 51,251 (187)

Janus Kinases in Leukemia. [PDF]

Cancers (Basel), 2021
Janus kinases (JAKs) transduce signals from dozens of extracellular cytokines and function as critical regulators of cell growth, differentiation, gene expression, and immune responses. Deregulation of JAK/STAT signaling is a central component in several human diseases including various types of leukemia and other malignancies and autoimmune diseases ...
Raivola J, Haikarainen T, Abraham BG, Silvennoinen O.   +3 more
europepmc   +6 more sources

Identification of the protein kinases Pyk3 and Phg2 as regulators of the STATc-mediated response to hyperosmolarity [PDF]

, 2014
Cellular adaptation to changes in environmental osmolarity is crucial for cell survival. In Dictyostelium, STATc is a key regulator of the transcriptional response to hyperosmotic stress. Its phosphorylation and consequent activation is controlled by two
A Kortholt, A Kortholt, AA Noegel, Adrian John Harwood, BK Gilsbach, C Blanc, Christoph S. Clemen, CR Thompson, DE Levy, H Kiu, H Kuwayama, H Towbin, J Faix, J Langenick, J Na, Jeffrey G. Williams, Jianbo Na, JM Goldberg, K Adler, KL Williams, L Gebbie, Linh Hai Vu, Ludwig Eichinger, M Brink, M Fukuzawa, M Gamper, MR Lee, NS Lee, P Farbrother, P Gatsios, R Kang, RH Insall, T Araki, T Araki, T Araki, T Araki, Tsuyoshi Araki, UK Laemmli   +37 more
core   +11 more sources

Janus kinase (JAK) inhibitors in the treatment of neoplastic and inflammatory disorders

Pharmacological Research, 2022
The Janus kinase (JAK) family of nonreceptor protein-tyrosine kinases consists of JAK1, JAK2, JAK3, and TYK2 (Tyrosine Kinase 2). Each of these proteins contains a JAK homology pseudokinase (JH2) domain that interacts with and regulates the activity of ...
Robert Roskoski, Jr.
doaj   +1 more source

New Applications of JAK/STAT Inhibitors in Pediatrics: Current Use of Ruxolitinib

Pharmaceuticals, 2022
Janus kinases (JAK) are a family of tyrosine kinases (JAK1, JAK2, JAK3, and TYK2) that transduce cytokine-mediated signals through the JAK–STAT metabolic pathway.
Annalisa Marcuzzi, Erika Rimondi, Elisabetta Melloni, Arianna Gonelli, Antonio Giacomo Grasso, Egidio Barbi, Natalia Maximova   +6 more
doaj   +1 more source

Janus kinases: dermatological perspective, a review

Journal of the Egyptian Women’s Dermatologic Society, 2020
Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription pathway.
Hanan R Nada, Maha F Elmasry, Dina A El Sharkawy, Sally Mamdouh   +3 more
doaj   +1 more source

Basics of Janus kinases: a review

Journal of the Egyptian Women’s Dermatologic Society, 2020
Janus kinases (JAKs) are a group of nonreceptor intracellular tyrosine kinases that could modify cytokine-mediated signals through the JAK-signal transducer and activator of transcription (STAT) pathway. The intracellular signaling pathway JAK/STAT has a
Hanan R Nada, Maha F Elmasry, Dina A El Sharkawy, Sally Mamdouh   +3 more
doaj   +1 more source

Jak Inhibitors for Treatment of Autoimmune Diseases: Lessons from Systemic Sclerosis and Systemic Lupus Erythematosus

Pharmaceuticals, 2022
Systemic sclerosis and systemic lupus erythematosus represent two distinct autoimmune diseases belonging to the group of connective tissue disorders.
Przemysław Kotyla, Olga Gumkowska-Sroka, Bartosz Wnuk, Kacper Kotyla   +3 more
doaj   +1 more source

The Janus kinases (Jaks) [PDF]

Genome Biology, 2004
The Janus kinase (Jak) family is one of ten recognized families of non-receptor tyrosine kinases. Mammals have four members of this family, Jak1, Jak2, Jak3 and Tyrosine kinase 2 (Tyk2). Birds, fish and insects also have Jaks. Each protein has a kinase domain and a catalytically inactive pseudo-kinase domain, and they each bind cytokine receptors ...
Yamaoka, Kunihiro, Saharinen, Pipsa, Pesu, Marko, Holt, Vance ET, Silvennoinen, Olli, O'Shea, John J   +5 more
openaire   +3 more sources

Acacetin Inhibits Cell Proliferation and Induces Apoptosis in Human Hepatocellular Carcinoma Cell Lines

Molecules, 2022
Human hepatocellular carcinoma (HCC) is the fifth most common cancer and the third leading cause of death across the world. Recent evidence suggests that STAT3 regulates proliferative, survival, metastasis, and angiogenesis genes in HCC.
Manal Alfwuaires, Hany Elsawy, Azza Sedky   +2 more
doaj   +1 more source

The role of janus kinases in the treatment of autoimmune skin diseases [PDF]

Farmacja Polska, 2021
The JAK / STAT signaling pathway is a pleiotropic signal transduction pathway for many biochemical substances that are ligands, for example cytokines, growth factor, leptin, erythropoietin or interferons.
Arnold Kukowka, Maria Salmanowicz, Magda Mądra, Bolesław Banach   +3 more
doaj   +1 more source