Advanced Science, EarlyView.This bioinspired acinus‐on‐a‐chip recapitulates VILI pathology, revealing that volutrauma drives P53/NF‐κB pathways while barotrauma triggers mitochondrial‐Wnt dysregulation. A fibrotic transitional cell cluster was identified. Pharmacological interventions targeting these pathways significantly ameliorated injury, establishing a mechanobiological ...
Heng Lu +10 more
wiley +1 more source
p53 Inhibits JC Virus DNA Replicationin Vivoand Interacts with JC Virus Large T-Antigen
Virology, 1996 The onset of DNA replication is an important step within the life cycle of the human neurotropic polyomavirus JC. In this report, evidence that both the human and the murine tumor suppressor protein p53 strongly inhibit JCV DNA replication in vivo is presented.
STAIB, CAROLINE +6 more
openaire +2 more sources
Charakterisierung JC Virus-spezifischer CD4+ T Zell Epitope in Gesunden
, 2013 Infection with John Cunningham virus (JCV) is very common in humans and usually remains asymptomatic in healthy individuals. However, under circumstances of severe immunocompromise, the polyomavirus JC may cause progressive multifocal leukoencephalopathy
Aly, Lilian Marlene
core
Expression of JC virus T-antigen in a patient with MS and glioblastoma multiforme
, 2002 Objective: To investigate the presence of human polyomavirus JC virus genome and the expression of the viral oncoprotein T-antigen in neoplastic cells of a patient with MS and a glioblastoma multiforme.
S. Enam +6 more
core +1 more source
, 2022 Development of Retroviral Vectors Encoding Anti-JC Virus Chimeric T Cell Receptors With Degenerate ...
Anthony J Bais (13285305)
core +1 more source
Fzd7 Restrains Pink1‐Dependent Mitophagy in Suture Stem Cells to Maintain Cranial Suture Patency
Advanced Science, EarlyView.How suture stem cells fail to preserve cranial suture patency remains incompletely understood. Integrated single‐cell and high‐resolution spatial transcriptomic analyses identify reduced Fzd7 expression in Prrx1+ suture stem cells as an early feature of craniosynostosis.
Xinyan Chen +10 more
wiley +1 more source
Natural‐Inspired Engineered Microalgae With Selenium Enrichment Enabled Potent Anti‐Tumor Immunity
Advanced Science, EarlyView.Se‐Ssp was engineered as a potent immunomodulator for activating innate immunity via the TLR and cGAS‐STING pathways, therefore converting “cold” tumors into “hot” tumors to achieve high efficacy and long‐term therapeutic outcomes. ABSTRACT Immunotherapy has shed light on clinical oncology for several decades.
Yuqi Yang +11 more
wiley +1 more source
Transcriptional regulation of the glial cell-specific JC virus by p53
, 2018 The human polyomavirus JC virus is the etiologic agent of progressive multifocal leukoencephalopathy (PML). As the JC virus early promoter directs cell-specific expression of the viral replication factor large T antigen, transcriptional regulation ...
김희선
core +1 more source
In ovo Antiviral Screening of Four Nigerian Medicinal Plants (Artemisia absinthium L., Annona senegalensis Pers., Erythrina senegalensis DC., and Jatropha curcas L.) Against Newcastle Disease Virus [PDF]
Journal of Shahrekord University of Medical SciencesBackground and aims: Newcastle disease virus (NDV) poses a major threat to global poultry production, driving interest in novel plant-based antiviral agents.
Sylvester Nefai Mathias +6 more
doaj +1 more source
JC Virus Intranuclear Inclusions Associated with PML-NBs Analysis by Electron Microscopy and Structured Illumination Microscopy [PDF]
, 2012 Progressive multifocal leukoencephalopathy is a fatal demyelinating disorder caused by JC virus infection. JC virus was recently found to target promyelocytic leukemia nuclear bodies (PML-NBs), punctuate domains in the nuclei.
Shishido-Hara, Yukiko +2 more
core +1 more source