Results 101 to 110 of about 71,442 (302)

Comparison of Receptor‐Mediated Endocytosis and Its Application to Enhance DNA Transfection by TFAMoplex

Advanced NanoBiomed Research, EarlyView.
We developed an assay to distinguish cellular binding from internalization. Compatible with microscopy and high‐throughput screening, the method identifies ligand‐mediated uptake. Applying top candidates to a protein‐based DNA carrier enhanced transfection efficiency, providing a rational strategy to improve non‐viral gene delivery systems.
David Scherer, Steffen Honrath, Jonas Kurmann, Alexander Klipp, Finn Brigger, Jean‐Christophe Leroux   +5 more
wiley   +1 more source

Charakterisierung JC Virus-spezifischer CD4+ T Zell Epitope in Gesunden

, 2013
Infection with John Cunningham virus (JCV) is very common in humans and usually remains asymptomatic in healthy individuals. However, under circumstances of severe immunocompromise, the polyomavirus JC may cause progressive multifocal leukoencephalopathy
Aly, Lilian Marlene
core  

Impaired antibody response causes persistence of prototypic T cell-contained virus

, 2009
CD8 T cells are recognized key players in control of persistent virus infections, but increasing evidence suggests that assistance from other immune mediators is also needed. Here, we investigated whether specific antibody responses contribute to control
André Fitsche, Bruno Eschli, Lukas Flatz, Senn, Beatrice M., Marylise Fernandez, Ahmed N Hegazy, Verbeek, J Sjef, Eschli, Bruno, Fink, Katja, Rami Sommerstein, Doron Merkler, Daniel D Pinschewer, Katja Fink, Siegrist, Claire-Anne, Odermatt, Bernhard, Andreas Bergthaler, Horvath, Edit, Fitsche, André, Bergthaler, Andreas, Claire-Anne Siegrist, Holdener, Martin, Beatrice M Senn, Verbeek, J. Sjef, Admar Verschoor, J Sjef Verbeek, Verschoor, Admar, Merkler, Doron, Edit Horvath, Pinschewer, Daniel, Martin Holdener, Bernhard Odermatt, Flatz, Lukas, Pinschewer, Daniel D., Sommerstein, Rami, Hegazy, Ahmed N., Fernandez, Marylise   +35 more
core   +1 more source

JC virus antibody status in a pediatric multiple sclerosis cohort: Prevalence, conversion rate and influence on disease severity

, 2014
Background: Because of the emergence of novel therapies for multiple sclerosis (MS) and the associated increased risk of progressive multifocal leukoencephalopathy, John Cunningham (JC) virus infection has become a focus of interest for neurologists ...
Hummel, Hannah-Maria, Brueck, Wolfgang, Ellenberger, David, Pfeifenbring, Sabine, Gärtner, Jutta, Huppke, Brenda, Huppke, Peter, Stark, Wiebke   +7 more
core   +1 more source

Modulation of the virus-receptor interaction by mutations in the V5 loop of feline immunodeficiency virus (FIV) following in vivo escape from neutralising antibody [PDF]

, 2010
<b>BACKGROUND:</b> In the acute phase of infection with feline immunodeficiency virus (FIV), the virus targets activated CD4+ T cells by utilising CD134 (OX40) as a primary attachment receptor and CXCR4 as a co-receptor.
Brian J Willett, Margaret J Hosie, Ayman Samman, McMonagle, Elizabeth L., Logan, Nicola, Nicola Logan, Hosie, Margaret J., Samman, Ayman, Willett, Brian J., Kraase, Martin, Martin Kraase, Elizabeth L McMonagle   +11 more
core   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

In ovo Antiviral Screening of Four Nigerian Medicinal Plants (Artemisia absinthium L., Annona senegalensis Pers., Erythrina senegalensis DC., and Jatropha curcas L.) Against Newcastle Disease Virus [PDF]

Journal of Shahrekord University of Medical Sciences
Background and aims: Newcastle disease virus (NDV) poses a major threat to global poultry production, driving interest in novel plant-based antiviral agents.
Sylvester Nefai Mathias, Emmanuel Halilu Mshelia, Chinenye Jane Ugwah-Oguejiofor, Ibrahim Yusuf Alkali, Aminu Ahmed Biambo, Mansur Lawal, Aliyu Hamidu Ahmed   +6 more
doaj   +1 more source

Integrated Clinical and Proteomic Profiling of CD19 Chimeric Antigen Receptor T Cell Therapy in Progressive Systemic Sclerosis

Arthritis &Rheumatology, EarlyView.
Objective To characterize the clinical, immunologic, and proteomic changes associated with CD19 chimeric antigen receptor T cell therapy in patients with progressive systemic sclerosis (SSc). Methods Patients with progressive SSc received CD19 chimeric antigen receptor (CAR)‐T cell therapy and were observed longitudinally for safety, clinical efficacy,
Chenhan Jia, Wanyi Lin, Zhangyi Zhao, Fenglin Wu, Chaoyu Gu, Yuankai Sun, Zhe Ding, Chang Wei, Xinyu Li, Cuiwei Xie, Peng Xia, Zhen Xia, Xuesong Liu, Shaoying Yang, Chunyan Zhang, Hanlin Yin, Liangjing Lu   +16 more
wiley   +1 more source

Genetic diversity of Brazilian isolates of feline immunodeficiency virus [PDF]

, 2010
We isolated Feline immunodeficiency virus (FIV) from three adult domestic cats, originating from two open shelters in Brazil. Viruses were isolated from PBMC following co-cultivation with the feline T-lymphoblastoid cell line MYA-1.
HAGIWARA, M. K., Richtzenhain, L.J., CRUZ, J. C. M., HOSIE, M. J., REIS, J. K. P., Hagiwara, M.K., Cruz, J.C.M., WILLETT, B. J., Hosie, M.J., Logan, N., Willett, B.J., BRANDAO, P. E., Teixeira, Bruno Marques, Reis, J.K.P., Brandão, P.E., RICHTZENHAIN, L. J.   +15 more
core   +1 more source

Increased plasma microbial tDR‐1 in at‐risk individuals is associated with decreased conversion to clinical rheumatoid arthritis and reduces an in vitro macrophage type 1 interferon response

Arthritis &Rheumatology, Accepted Article.
Background Microbial small RNAs (sRNAs) can regulate human genes. Higher plasma concentrations of microbial tRNA‐derived RNA‐1 (tDR‐1) were previously associated with lower rheumatoid arthritis (RA) disease activity. This study examined whether tDR‐1 concentrations differ in anti‐cyclic citrullinated peptide‐3 positive (CCP3+) at‐risk individuals (ARI)
Anastasiia Phothisane, Tulsi K Joishy, Carolina Ramirez‐Becerra, Qiong Wu, Jennifer Seifert, Marie L Feser, Jill M Norris, M Kristen Demoruelle, LauraKay Moss, Kevin D Deane, V Michael Holers, Michelle J Ormseth   +11 more
wiley   +1 more source