Results 191 to 200 of about 66,683 (260)

The impact of social distancing measures on anti-JC virus serostatus changes before and during the COVID-19 pandemic in US patients with multiple sclerosis. [PDF]

Mult Scler
Krieger SC, Sinks S, Huang F, Steverson J, Kalina TJ, White K, Avila RL.   +6 more
europepmc   +1 more source

Dental Pulp Stem Cell‐Derived Intracellular Vesicles Inhibit OSCC by Delivering PTEN to Suppress PI3K/AKT/mTOR Signalling Pathway

Cell Proliferation, EarlyView.
DPSC‐IVs suppressed PI3K/AKT/mTOR signalling pathway by delivering PTEN to tumour cells, which reduced the expression of Bcl‐2 and elevated that of Bax. Meanwhile, DPSC‐IVs activated PINK1/Parkin mediated mitophagy, which further raised ROS levels.
Yu Luo, Qiang Qin, Wenting She, Xiangying Wang, Xiqin Li, Chenxuan Shu, Ruohan Li, Ziwei Li, Dongjie Fu, Yan He, Qingsong Ye   +10 more
wiley   +1 more source

Lactate‐Primed NETosis Modulates Hepatic Regeneration During Acute Liver Failure via the TLR9/KLF15/AJUBA Axis

Cell Proliferation, EarlyView.
This study elucidates a novel Kupffer cell‐neutrophil‐hepatocyte axis that drives metabolic‐immune crosstalk during acute liver failure. Specifically, lactate‐primed NETs release links metabolic reprogramming to NETosis‐induced regenerative failure in hepatocytes via the TLR9/KLF15/AJUBA axis.
Jin Guo, Xiaoya Zhang, Danmei Zhang, Chunxia Shi, Luwen Wang, Zuojiong Gong   +5 more
wiley   +1 more source

Progressive multifocal leukoencephalopathy associated with systemic lupus erythematosus: longitudinal observation of lymphocytes, JC virus in cerebrospinal fluid, and brain magnetic resonance imaging. [PDF]

J Neurovirol
Yamada H, Toko M, Nakamori M, Ueno H, Aoki S, Sugimoto T, Yasutomi H, Nakamichi K, Maruyama H.   +8 more
europepmc   +1 more source

Inborn errors of immunity in children with neuroinflammation

Developmental Medicine &Child Neurology, EarlyView.
Abstract Inborn errors of immunity (IEIs), an expanding group of monogenic disorders with diverse clinical manifestations, are increasingly recognized to include neuroinflammatory disease. Examples of diseases included under this umbrella are Aicardi–Goutières syndrome, deficiency of adenosine deaminase 2, familial haemophagocytic lymphohistiocytosis ...
Eppie M Yiu, Dilan Dissanayake, Jessie Cunningham, Helen Branson, Ori Scott, E Ann Yeh   +5 more
wiley   +1 more source

Long‐Term Follow‐Up Incidence of Type 1 Diabetes and Associated Autoimmune Diseases in First‐Degree Relatives

Diabetes, Obesity and Metabolism, EarlyView.
ABSTRACT Background First‐degree relatives (FDRs) of individuals with type 1 diabetes (T1D) carry a significantly elevated risk of developing autoimmune diseases, including celiac disease (CD) and autoimmune thyroid disease (AITD). The DiaUnion 1.0 study aimed to characterize one‐time autoantibodies, genetic risk profiles and long‐term progression to ...
Julie H. Christensen, Gitte Lindved Petersen, Simranjeet Kaur, Alexander Lind, Samia Hamdan, Maria Naredi Scherman, Jesper Johannesen, Daniel Agardh, Julie C. Antvorskov, Flemming Pociot   +9 more
wiley   +1 more source

Potential Role of Liver Transplantation for Child–Pugh Class A Hepatocellular Carcinoma: Prognosis and Medical Expenditure in Japan—A Retrospective Single‐Center Study

Hepatology Research, EarlyView.
Among patients with CP‐A HCC initially within the Japan criteria, some lose oncological eligibility for LT before hepatic decompensation. Further studies are needed to identify baseline factors associated with poor outcomes and to evaluate their relevance to future LT candidacy.
Akihiro Seki, Tomoyoshi Chiba, Shintaro Yagi, Rika Horii, Noboru Takata, Hiroki Nomura, Masaki Miyazawa, Tomoyuki Hayashi, Takeshi Terashima, Shinichi Nakanuma, Mitsuyoshi Okazaki, Satoshi Takada, Tatsuya Yamashita, Masao Honda, Hajime Takatori, Tetsuro Shimakami, Taro Yamashita   +16 more
wiley   +1 more source

Investigation of Epstein-Barr virus, Cytomegalovirus, Human herpesvirus 6, and Polyoma viruses (JC virus, BK virus) among Gastric cancer patients: A cross sectional study. [PDF]

Health Sci Rep
Soltani S, Farahani A, Shahbahrami R, Shateri Z, Emadi MS, Pakzad R, Lotfi M, Asanjarani B, Rasti A, Erfani Y, Siri G.   +10 more
europepmc   +1 more source

Fatal encephalopathy with wild-type JC virus and ruxolitinib therapy. [PDF]

Ann Neurol, 2019
Reoma LB, Trindade CJ, Monaco MC, Solis J, Montojo MG, Vu P, Johnson K, Beck E, Nair G, Khan OI, Quezado M, Hewitt SM, Reich DS, Childs R, Nath A.   +14 more
europepmc   +1 more source

Migration pathways and HIV care Cascade among newly enrolled adult patients in a tertiary clinic in Montréal, Canada

HIV Medicine, EarlyView.
Abstract Objectives Migrants are disproportionately affected by HIV and face inequities in accessing care. This study examined the HIV care cascade among newly registered adults at the Chronic Viral Illness Service (CVIS). Methods We conducted a retrospective cohort study of adults (≥18 years) living with HIV and newly registered at the CVIS, in ...
Kathy Nodzynski, David Lessard, Dominic Chu, Nadine Kronfli, Claire Dufrêne‐Boelen, Sean Yaphe, Marina Klein, Jean‐Pierre Routy, Alexandra Hamel, Cecilia Costiniuk, Alexandra de Pokomandy, Serge Vicente, Krescyn Moonsamy, Nashira Popovic, Joseph Cox, Bertrand Lebouché   +15 more
wiley   +1 more source