Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich +24 more
wiley +1 more source
Inter-assay variability in anti-JC virus serology in the era of natalizumab biosimilars: implications for PML risk stratification. [PDF]
Caminero AB, Oreja-Guevara C.
europepmc +1 more source
Teaching NeuroImage: Cerebellar Atrophy Due to JC Virus Granule Cell Neuronopathy: A Clinical Syndrome Distinct From Classic PML. [PDF]
Silva-Rosas C +3 more
europepmc +1 more source
Carrion ecology: concepts, interdisciplinary synthesis, and perspectives
ABSTRACT Carrion is a ubiquitous resource in both terrestrial and aquatic ecosystems, yet it has long been overlooked in ecological research. Over the past two decades, studies on carrion and the many organisms that exploit it have flourished, revealing not only wide‐ranging ecological functions but also significance far beyond ecology.
Marcos Moleón +38 more
wiley +1 more source
Detection of JC virus DNA in CSF of pediatric patients with non-PML neurological disorders. [PDF]
Hemmati N, Alipour AH, Kiasari BA.
europepmc +1 more source
A human-derived 3D brain organoid model to study JC virus infection. [PDF]
Barreras P +8 more
europepmc +1 more source
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal +8 more
wiley +1 more source
Could a macular telangiectasia type 2-like phenotype characterize retinal JC virus infection? [PDF]
Varenne F +11 more
europepmc +1 more source
The Oncogenic Roles of JC Virus T Antigen in Breast Carcinogenesis. [PDF]
Zheng HC, E Y, Cui ZG, Zhao S, Zhang Y.
europepmc +1 more source

