Results 171 to 180 of about 1,276,875 (301)

Safety and pharmacokinetics of inhaled aloxistatin: A first‐in‐human phase 1 dose escalation trial

open access: yesBritish Journal of Clinical Pharmacology, EarlyView.
Aims Aloxistatin (E64d) is a membrane‐permeable cysteine protease inhibitor prodrug that is converted by esterases to the active metabolite E64c (loxistatin). This first‐in‐human study evaluated the safety, tolerability and pharmacokinetics of single ascending doses of inhaled E64d in healthy volunteers.
Sebastian Fähndrich   +24 more
wiley   +1 more source

Carrion ecology: concepts, interdisciplinary synthesis, and perspectives

open access: yesBiological Reviews, EarlyView.
ABSTRACT Carrion is a ubiquitous resource in both terrestrial and aquatic ecosystems, yet it has long been overlooked in ecological research. Over the past two decades, studies on carrion and the many organisms that exploit it have flourished, revealing not only wide‐ranging ecological functions but also significance far beyond ecology.
Marcos Moleón   +38 more
wiley   +1 more source

A human-derived 3D brain organoid model to study JC virus infection. [PDF]

open access: yesJ Neurovirol, 2022
Barreras P   +8 more
europepmc   +1 more source

A case series of necrotizing periodontal diseases in hospitalized patients: What hasn't been said yet?

open access: yesClinical Advances in Periodontics, EarlyView.
Abstract Background Necrotizing periodontal diseases (NPDs) are uncommon and severe inflammatory conditions characterized by tissue necrosis, painful ulceration, and rapid clinical progression, frequently associated with systemic immunosuppression. Limited data exist regarding their clinical presentation and management in hospital settings.
Osmaria Letthycia Carvalho Leal   +8 more
wiley   +1 more source

Could a macular telangiectasia type 2-like phenotype characterize retinal JC virus infection? [PDF]

open access: yesAIDS
Varenne F   +11 more
europepmc   +1 more source

The Oncogenic Roles of JC Virus T Antigen in Breast Carcinogenesis. [PDF]

open access: yesFront Mol Biosci, 2021
Zheng HC, E Y, Cui ZG, Zhao S, Zhang Y.
europepmc   +1 more source

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