Results 181 to 190 of about 1,276,875 (301)

The Governance Gap: Democratizing Drug Development Through Decision Architecture

Clinical Pharmacology &Therapeutics, EarlyView.
Drug development is most exposed to governance failure where it can least afford it, in global health. The field has more predictive power than at any point in its history and roughly the same failure rate it had a decade ago. We argue that this paradox persists because the field has invested heavily in prediction science while neglecting decision ...
Craig R. Rayner, Nancy E. Martin, Danielle Smith, Eliza Kruger, Carl M.J. Kirkpatrick, Goonaseelan (Colin) Pillai, Katy Moore, Darrell Nix, Cristina Donini, Jakob P. Cramer, Edmundo Muniz, Natalia Muniz, Ernst Bos, Douglas McNair, Shyam Bhaskaran, Mark Sullivan, Dan Hartman   +16 more
wiley   +1 more source

Molecular characterization of JC virus in progressive multifocal leukoencephalopathy cases from India. [PDF]

Sci Rep
Palani GS, Telang S, Reddy V, Dhanya K, Ashwini MA, Mani RS.   +5 more
europepmc   +1 more source

Treatment of Inflammatory Bowel Disease and Pediatric Onset Multiple Sclerosis With Ocrelizumab and Ustekinumab in a JC-virus Positive Adolescent. [PDF]

JPGN Rep, 2022
Lambert-Jenkins K, Rossman I, Watson KL.
europepmc   +1 more source

Should natalizumab be used despite JC virus positivity?-Commentary. [PDF]

Mult Scler
Hedström AK.
europepmc   +1 more source

Transforming the Landscape of Drug Innovation in AI Era: AlphaFold 3 and Beyond

Exploration, EarlyView.
Traditional drug development is time‐consuming and costly, and new tools are urgently needed to improve efficiency. This perspective reviews the considerable potential of AlphaFold 3 as a next‐generation predictive tool for drug discovery, particularly in target identification and validation, hit identification and lead optimization, and personalized ...
Songlin He, Liangbin Zhou, Xiaoshuai Wang, Chenzhong Li, Cheng Jiang, Rocky S. Tuan, Zhong Alan Li   +6 more
wiley   +1 more source

Persistence of intraocular JC-virus associated with a MacTel phenotype. [PDF]

AIDS
Hupin N, Hoogewoud F, Sallo FB, Vermeirsch S, Suttels V, Guex-Crosier Y.   +5 more
europepmc   +1 more source

Progressive multifocal leukoencephalopathy and the spectrum of JC virus-related disease. [PDF]

Nat Rev Neurol, 2021
Cortese I, Reich DS, Nath A.
europepmc   +1 more source

Transoral Robotic Surgery for Oropharyngeal Squamous Cell Carcinoma: Glossotonsillar Sulcus Involvement Conveys an Unfavorable Oncological Outcome

Head &Neck, EarlyView.
ABSTRACT Background Transoral robotic surgery (TORS) is widely used in management of early‐stage primary oropharyngeal squamous cell carcinoma (OPSCC). Tumors involving the glossotonsillar sulcus (GTS) are hypothesized to confer worse oncological outcomes compared to those situated in the rest of the oropharynx, with a paucity of evidence to support ...
Johan S. Nilsson, John C. Hardman, James Tsimiklis, Bora Jeong, Maryam Khan, Jonathan Daniel, Giri Krishnan, Andrew Foreman, Suren Krishnan, John‐Charles Hodge   +9 more
wiley   +1 more source

Visual and Neuro-Ophthalmic Manifestations of John Cunningham (JC) Virus-Related Natalizumab-Associated Progressive Multifocal Leukoencephalopathy in Multiple Sclerosis: A Systematic Review. [PDF]

Cureus
Jangirashvili T, Parthiv O, Shengelia L, Tabeshadze Z, Kontchoshvili A, Waked CA, Tamer RM.   +6 more
europepmc   +1 more source

Human neurotropic polyomavirus, JC virus, late coding region encodes a novel nuclear protein, ORF4, which targets the promyelocytic leukemia nuclear bodies (PML-NBs) and modulates their reorganization. [PDF]

Virology, 2023
Saribas AS, Bellizzi A, Wollebo HS, Beer T, Tang HY, Safak M.   +5 more
europepmc   +1 more source