Results 111 to 120 of about 33,016,997 (287)

Self‐Assembling Peptide‐Adjuvant Conjugate (SaPAC) Platform for Precision Cancer Immunotherapy

Advanced Science, EarlyView.
A self‐assembling peptide–adjuvant conjugate links neoantigens to TLR7 agonism, forming cationic nanoparticles that enhance lymph‐node retention, dendritic‐cell activation, and antitumor T‐cell immunity. This chemically defined platform shows how synchronized antigen and innate stimulation can be adapted across melanoma, bladder cancer, and triple ...
Yang‐Fan Wu, Jing‐Chu Hu, Ye‐Fan Hu, Wen‐Jun Li, Li Rong, Ren‐Hao Li, Yuan Yao, Lehan Hu, Xiao‐Lei Wang, Bao‐Zhong Zhang, Yicheng Lu, Shing‐Fung Chow, Canhui Su, Thomas Yau, Clive Yik‐Sham Chung, Jian‐Dong Huang   +15 more
wiley   +1 more source

Burnout as a Predictor of Job Satisfaction in Peruvian Nurses: The Mediating Role of Work Engagement

Nursing Reports
Background: Burnout and job satisfaction are widely studied phenomena within the field of occupational health, particularly among nursing professionals exposed to high work demands.
Irene J. Escalante-Zúñiga, Elizabeth Pérez-Flores, María Teresa Cabanillas-Chávez, Liset Z. Sairitupa-Sanchez, Sandra B. Morales-García, Oriana Rivera-Lozada, Wilter C. Morales-García   +6 more
doaj   +1 more source

The study of Personal Resources of Psychological Capital and Problem-Focused coping in the JD-R Model

, 2022
This research investigated the positive effects of psychological capital (psycap) and problem-focused coping on job stress and organizational citizenship behaviors (OCB). By using the Job demands and resources model (JD-R model) and conservation of resources theory (COR), we propose that problem-focused coping act as a mediator in a way that it can ...
openaire   +2 more sources

Collagen‐Binding IL‐15 Immunocytokine Armed Oncolytic Adenovirus Establishes a Self‐Reinforcing Immunostimulatory Milieu to Potentiate Antitumor Immunity

Advanced Science, EarlyView.
Repurposing the dense tumor stroma from a physical barrier into an anchoring scaffold, an engineered oncolytic adenovirus encoding IL15C‐CBD overcomes the immunosuppressive microenvironment in triple‐negative breast cancer. Intratumoral viral replication secretes this collagen‐anchored immunocytokine, forming a localized cytokine depot.
Yaqi Yang, Xiaoxiao Liu, Junqiang Ding, Jinliang Xu, Jianhua Zhang, Hanchang Zhang, Rong Yang, Sha Li, Lu Zheng, Runping Su, Yue Zhao, Jianxiao Wu, Hao Li, Changyou Zhan, Xihui Gao   +14 more
wiley   +1 more source

Enhancing employees’ workplace well-being through workplace digitization: exploring the mediating roles of job demands and digital anxiety

Frontiers in Psychology
IntroductionWith the arrival of the digital era, workplaces are undergoing radical changes, and digitalization not only enhances work efficiency but also significantly influences employees’ workplace well-being.
Zhiyong Han, Guoqing Song, Yanlong Zhang, Lei Yan, Lei Yan   +4 more
doaj   +1 more source

Fumarate Hydratase Lactylation Exacerbates Traumatic Brain Injury Pathology via Mitochondrial Dysfunction and Neuroinflammation

Advanced Science, EarlyView.
Tian et al. reveal that FH K112 lactylation is elevated after TBI, leading to fumarate accumulation, mitochondrial damage, mtDNA release and amplified neuroinflammation. AARS2 and SIRT3 act as the “writer” and “eraser” for FH K112 lactylation. The peptide Pep‐K112 targeting this site alleviates brain injury, highlighting a potential therapeutic target.
Yang Tian, Shuoyao Ma, Bo Yang, Fei Gao, Hao Guo, Haixiao Liu, Xun Wu, Wenxing Cui, Jingyu Dong, Qian Lin, Yufeng Ge, Jin Ma, Jiazhen Zhao, Yongzhi Zhang, Dongzhi Xue, Jiaxin Tian, Ziwen Zhang, Kai Wang, Meng Xu, Dayun Feng, Jinpeng Zhou, Yan Qu   +21 more
wiley   +1 more source

The inverted U-shaped relationship between judicial development and economic growth: evidence from China

Humanities & Social Sciences Communications
Judicial development (JD) is a crucial factor influencing regional economic growth. This study delves into the non-linear relationship between JD and regional economic performance.
Xin Zhang, Decai Tang, Xiejun Cheng
doaj   +1 more source

Bioinspired Metastable Transient Peeling for Repeatable Rapid Release

Advanced Science, EarlyView.
Inspired by the explosive seed ejection of the squirting cucumber, this work introduces metastable transient peeling that temporally regulates stored interfacial energy release via a tunable energy barrier. A viscoelastic hemispherical gripper achieves 52 ms ultrafast, residue‐free release with 300 000‐cycle durability, enabling damage‐free handling of
Lvzhou Li, Qingyue Li, Yao Hu, Xu Dong, Xiangli Wen, Kai Zhu, Yaoyao Jiang, Yu Tian, Jianning Ding   +8 more
wiley   +1 more source

Palaeoproteomic Deconvolution of Physical and Genetic Collagen Mixtures

Advanced Science, EarlyView.
ClassiCOL_v2 uses a novel “peptide patching” framework that treats any collagen sample as a patchwork of peptide sequences derived from phylogenetically related species. This allows the algorithm to simultaneously resolve two previously intractable problems: multi‐species samples and/or database deficiencies.
Ian Engels, Tristan Dedrie, Synnøve K. Mo, Simon Van de Vyver, Thijs R. A. Vandenbroucke, Kévin Di Modíca, Jan Decher, Alice Toso, Dieter Deforce, Simon Daled, Alexandra Burnett, Grégory Abrams, Maarten Dhaenens   +12 more
wiley   +1 more source

Resilient Teachers in a Strained System: Mental Health and Resilience Amidst School Transformation Processes

Education Sciences
In light of profound transformation processes within the education system—such as digitalization, increasing societal pluralization, and global crises—growing attention is being paid to the mental health and resilience of teachers.
Christian Reintjes, Till Kaiser, Isabelle Winter, Gabriele Bellenberg   +3 more
doaj   +1 more source