Modulation of the antagonistic properties of an insulin mimetic peptide by disulfide bridge modifications. [PDF]
J Pept Sci, 2023 Insulin mimetics with agonistic or antagonistic effects toward the receptor could find applications in treating diabetes or malignant diseases. As demonstrated, it is possible to modulate the functional properties of insulin receptor unnatural peptide ligands using disulfide bridge mimetics. Insulin is a peptide responsible for regulating the metabolic
Lubos M +7 more
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Characterization of insulin crystalline form in isolated β-cell secretory granules [PDF]
Open Biology, 2022 Insulin is stored in vivo inside the pancreatic β-cell insulin secretory granules. In vitro studies have led to an assumption that high insulin and Zn2+ concentrations inside the pancreatic β-cell insulin secretory granules should promote insulin ...
Seiya Asai +7 more
doaj +2 more sources
Application of Capillary and Free-Flow Zone Electrophoresis for Analysis and Purification of Antimicrobial β-Alanyl-Tyrosine from Hemolymph of Fleshfly Neobellieria bullata [PDF]
Molecules, 2021 The problem of a growing resistance of bacteria and other microorganisms to conventional antibiotics gave rise to a search for new potent antimicrobial agents.
Veronika Šolínová +4 more
doaj +2 more sources
Insulin receptor Arg717 and IGF-1 receptor Arg704 play a key role in ligand binding and in receptor activation [PDF]
Open Biology, 2023 The insulin receptor (IR, with its isoforms IR-A and IR-B) and the insulin-like growth factor 1 receptor (IGF-1R) are related tyrosine kinase receptors.
Anna Kertisová +7 more
doaj +2 more sources
Non-glycosylated IGF2 prohormones are more mitogenic than native IGF2 [PDF]
Communications Biology, 2023 Insulin-like Growth Factor-2 (IGF2) is important for the regulation of human embryonic growth and development, and for adults’ physiology. Incorrect processing of the IGF2 precursor, pro-IGF2(156), leads to the formation of two IGF2 proforms, big-IGF2(87)
Pavlo Potalitsyn +11 more
doaj +2 more sources
From venom peptides to a potential diabetes treatment [PDF]
eLife, 2019 Cone snails have evolved a variety of insulin-like molecules that may help with the development of better treatments for diabetes.
Jiří Jiráček, Lenka Žáková
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Characterization of viral insulins reveals white adipose tissue-specific effects in mice [PDF]
Molecular Metabolism, 2021 Objective: Members of the insulin/insulin-like growth factor (IGF) superfamily are well conserved across the evolutionary tree. We recently showed that four viruses in the Iridoviridae family possess genes that encode proteins highly homologous to human ...
Martina Chrudinová +10 more
doaj +2 more sources
A radioligand binding assay for the insulin-like growth factor 2 receptor. [PDF]
PLoS ONE, 2020 Insulin-like growth factors 2 and 1 (IGF2 and IGF1) and insulin are closely related hormones that are responsible for the regulation of metabolic homeostasis, development and growth of the organism.
Pavlo Potalitsyn +7 more
doaj +2 more sources
Structural Perspectives of Insulin Receptor Isoform-Selective Insulin Analogs [PDF]
Frontiers in Endocrinology, 2017 A significant drawback of the exogenous administration of insulin to diabetics is the non-physiological profile of insulin action resulting in the insufficient suppression of hepatic glucose production, which is the main contributing factor to diabetic ...
Jiří Jiráček, Lenka Žáková
doaj +2 more sources
The efficiency of insulin production and its content in insulin-expressing model β-cells correlate with their Zn2+ levels [PDF]
Open Biology, 2020 Insulin is produced and stored inside the pancreatic β-cell secretory granules, where it is assumed to form Zn2+-stabilized oligomers. However, the actual storage forms of this hormone and the impact of zinc ions on insulin production in vivo are not ...
Petra Dzianová +12 more
doaj +2 more sources