Results 11 to 20 of about 262,074 (332)
Involvement of the JNK/FOXO3a/Bim Pathway in Neuronal Apoptosis after Hypoxic-Ischemic Brain Damage in Neonatal Rats. [PDF]
, 2015 c-Jun N-terminal kinase (JNK) plays a key role in the regulation of neuronal apoptosis. Previous studies have revealed that forkhead transcription factor (FOXO3a) is a critical effector of JNK-mediated tumor suppression.
Li, Deyuan +8 more
core +16 more sources
INFLUENCE OF AN INHIBITOR OF JNK ON THE SECRETION OF THE INFLAMMASOME–DEPENDENT PROINFLAMMATORY CYTOKINES [PDF]
Journal of IMAB, 2020 Purpose: In this study, we determine the influence of prolonged exposure on organic air pollutants, on the secretion of inflammasome-dependent cytokines IL-1β and IL-18.
Boncho Grigorov +3 more
doaj +1 more source
JNK Pathway in CNS Pathologies [PDF]
International Journal of Molecular Sciences, 2021 The c-Jun N-terminal Kinase (JNK) signalling pathway is a conserved response to a wide range of internal and external cellular stress signals. Besides the stress response, the JNK pathway is involved in a series of vital regulatory mechanisms during development and adulthood that are critical to maintain tissue homeostasis. These mechanisms include the
Teresa de los Reyes Corrales +2 more
openaire +3 more sources
Autophagy Reports, 2023 During organogenesis cellular homeostasis plays a crucial role in patterning and growth. The role of promoter proximal pausing of RNA polymerase II, which regulates transcription of several developmental genes by GAGA factor or Motif 1 Binding Protein ...
Anuradha Venkatakrishnan Chimata +4 more
doaj +1 more source
Disease Models & Mechanisms, 2021 The mammalian central nervous system (CNS) exhibits limited regenerative capacity and the mechanisms that mediate its regeneration are not fully understood.
María Losada-Pérez +2 more
doaj +1 more source
The expression of MAPK signaling pathways in conjunctivochalasis [PDF]
International Journal of Ophthalmology, 2019 This study investigated the potential role of MAPK signaling pathways in conjunctivochalasis (CCH). Twenty loose conjunctival biopsy samples from 20 CCH and 15 conjunctival biopsy samples from 15 normal controls (CON) were collected.
Yuan-Ling Jia +4 more
doaj +1 more source
Spz/Toll-6 signal guides organotropic metastasis in Drosophila
Disease Models & Mechanisms, 2019 Targeted cell migration plays important roles in developmental biology and disease processes, including in metastasis. Drosophila tumors exhibit traits characteristic of human cancers, providing a powerful model to study developmental and cancer biology.
Ketu Mishra-Gorur +5 more
doaj +1 more source
Impact of JNK and Its Substrates on Dendritic Spine Morphology
Cells, 2020 The protein kinase JNK1 exhibits high activity in the developing brain, where it regulates dendrite morphology through the phosphorylation of cytoskeletal regulatory proteins.
Emilia Komulainen +6 more
doaj +1 more source
Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells [PDF]
The Korean Journal of Internal Medicine, 2021 Background/Aims Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years.
Yoo Jin Na +5 more
doaj +1 more source
Covalent JNK inhibitors? [PDF]
Proceedings of the National Academy of Sciences, 2009 Stebbins et al. reported novel JNK inhibitors that block JNK binding to the scaffolding protein JIP1 (1). The most potent compound, BI-78D3, was postulated to bind noncovalently to JNK at the JIP1 site. The binding data and structure of BI-78D3 suggest, however, that BI-78D3 may instead act through covalent modification of JNK at Cys163.
John L, Stebbins +12 more
openaire +4 more sources