Results 11 to 20 of about 297,973 (327)

JNK Pathway in CNS Pathologies [PDF]

International Journal of Molecular Sciences, 2021
The c-Jun N-terminal kinase (JNK) signalling pathway is a conserved response to a wide range of internal and external cellular stress signals. Beside the stress response, the JNK pathway is involved in a series of vital regulatory mechanisms during ...
Teresa de los Reyes Corrales, María Losada-Pérez, S. Casas-Tintó   +2 more
semanticscholar   +4 more sources

JNK signaling in apoptosis [PDF]

Oncogene, 2008
Jun N-terminal kinases or JNKs play a critical role in death receptor-initiated extrinsic as well as mitochondrial intrinsic apoptotic pathways. JNKs activate apoptotic signaling by the upregulation of pro-apoptotic genes through the transactivation of specific transcription factors or by directly modulating the activities of mitochondrial pro- and ...
DN Dhanasekaran, E. Reddy
semanticscholar   +3 more sources

Impact of JNK and Its Substrates on Dendritic Spine Morphology

Cells, 2020
The protein kinase JNK1 exhibits high activity in the developing brain, where it regulates dendrite morphology through the phosphorylation of cytoskeletal regulatory proteins.
Emilia Komulainen, Artemis Varidaki, Natalia Kulesskaya, Hasan Mohammad, Christel Sourander, Heikki Rauvala, Eleanor T. Coffey   +6 more
doaj   +1 more source

Metformin enhances the cytotoxic effect of nilotinib and overcomes nilotinib resistance in chronic myeloid leukemia cells [PDF]

The Korean Journal of Internal Medicine, 2021
Background/Aims Nilotinib is used for treating patients with imatinib-sensitive or -resistant chronic myeloid leukemia (CML); however, nilotinib-resistant cases have been observed in recent years.
Yoo Jin Na, Eun Sang Yu, Dae Sik Kim, Dae-Hee Lee, Sang Cheul Oh, Chul Won Choi   +5 more
doaj   +1 more source

The JNK Signaling Pathway in Inflammatory Skin Disorders and Cancer

Cells, 2020
The c-Jun N-terminal kinases (JNKs), with its members JNK1, JNK2, and JNK3, is a subfamily of (MAPK) mitogen-activated protein kinases. JNK signaling regulates a wide range of cellular processes, including cell proliferation, differentiation, survival ...
M. Hammouda, Amy E. Ford, Yuan Liu, Jennifer Y. Zhang   +3 more
semanticscholar   +1 more source

Covalent JNK inhibitors? [PDF]

Proceedings of the National Academy of Sciences, 2009
Stebbins et al. reported novel JNK inhibitors that block JNK binding to the scaffolding protein JIP1 (1). The most potent compound, BI-78D3, was postulated to bind noncovalently to JNK at the JIP1 site. The binding data and structure of BI-78D3 suggest, however, that BI-78D3 may instead act through covalent modification of JNK at Cys163.
John L, Stebbins, Surya K, De, Thomas, Machleidt, Barbara, Becattini, Jesus, Vazquez, Christian, Kuntzen, Li-Hsing, Chen, Jason F, Cellitti, Megan, Riel-Mehan, Aras, Emdadi, Giovanni, Solinas, Michael, Karin, Maurizio, Pellecchia   +12 more
openaire   +4 more sources

Curcumin Ameliorates Lead-Induced Hepatotoxicity by Suppressing Oxidative Stress and Inflammation, and Modulating Akt/GSK-3β Signaling Pathway

Biomolecules, 2019
Lead (Pb) is a toxic heavy metal pollutant with adverse effects on the liver and other body organs. Curcumin (CUR) is the principal curcuminoid of turmeric and possesses strong antioxidant and anti-inflammatory activities.
Ahlam Alhusaini, Laila Fadda, Iman H. Hasan, Enas Zakaria, Abeer M. Alenazi, Ayman M. Mahmoud   +5 more
doaj   +1 more source

Protein convertase subtilisin/Kexin type 9 inhibits hepatocellular carcinoma growth by interacting with GSTP1 and suppressing the JNK signaling pathway

Cancer Biology & Medicine, 2022
Objective: Protein convertase subtilisin/Kexin type 9 (PCSK9) has been found to be closely associated with the occurrence and development of numerous tumors.
Mingyan He, Jing Hu, Tingting Fang, Wenqing Tang, Bei Lv, Biwei Yang, Jinglin Xia   +6 more
doaj   +1 more source

Localized JNK signaling regulates organ size during development. [PDF]

, 2016
A fundamental question of biology is what determines organ size. Despite demonstrations that factors within organs determine their sizes, intrinsic size control mechanisms remain elusive.
Beachy, Philip A, Carlos Pastor-Pareja, José, Willsey, A Jeremy, Willsey, Helen Rankin, Xu, Tian, Zheng, Xiaoyan   +5 more
core   +3 more sources

JNK inhibition sensitises hepatocellular carcinoma cells but not normal hepatocytes to the TNF-related apoptosis-inducing ligand. [PDF]

, 2009
Background: cJun terminal kinase (JNK) is constitutively activated in most hepatocellular carcinomas (HCCs), yet its exact role in carcinogenesis remains controversial.
Bruns, Christiane, Camaj, Peter, De Toni, Enrico, Eichhorst, Sören T., Gallmeier, Eike, Gerbes, Alexander L., Göke, Burkhard, Kolligs, Frank T., Mucha, Simon R., Rizzani, Antonia, Thasler, Wolfgang E.   +10 more
core   +1 more source