Results 191 to 200 of about 262,074 (332)

Vascular Calcification: Mechanisms, Models, and Therapies

iNew Medicine, EarlyView.
ABSTRACT Vascular calcification represents an active multifactorial process that mirrors several key features of skeletal bone mineralization. Clinically, it is characterized by diminished arterial compliance and increased arterial wall stiffness, both of which serve as independent predictors of significant adverse cardiovascular events.
Wenya Zhu, Shu Yang, Ziyi Chen, Xiaoxiao Yang, Zhen Liang, Yuanli Chen   +5 more
wiley   +1 more source

Mutually exclusive alternative pre-mRNA splicing promotes adaptive metabolic stress signaling by JNK. [PDF]

Proc Natl Acad Sci U S A
Lee A, Gentzler A, Fitzpatrick D, Raju Ponny S, Aydemir O, Han MS, Lewis CA, Gao G, Davis RJ.   +8 more
europepmc   +1 more source

Polyubiquitination of Transforming Growth Factor β-activated Kinase 1 (TAK1) at Lysine 562 Residue Regulates TLR4-mediated JNK and p38 MAPK Activation [PDF]

, 2015
I‐Ting Chen, Pang‐Hung Hsu, Wan‐Ching Hsu, Nien‐Jung Chen, Ping‐Hui Tseng   +4 more
openalex   +1 more source

JNK and obesity [PDF]

Genome Biology, 2002
openaire   +1 more source

N6‐Methyladenosine (m6A) in Liver Disease: Pathogenic Mechanisms and Therapeutic Potential

iNew Medicine, EarlyView.
ABSTRACT Accumulating evidence highlights the critical role of epigenetic modifications, particularly N6‐methyladenosine (m6A), in liver disease. As the most abundant RNA modification in eukaryotic cells, m6A is dynamically regulated by multicomponent m6A methyltransferases (e.g., METTL3 and METTL14), demethylases (FTO and ALKBH5), and m6A‐binding ...
Yingfen Chen, Ru Ya, Ziling Zhang, Siyue Dong, Seol Hee Park, Wonhyo Seo, Yong He   +6 more
wiley   +1 more source

MAPK signaling pathways in host immune regulation during Mycobacterium tuberculosis infection. [PDF]

Front Immunol
Diao YF, Wang JY, Tan XY, Yuan JS.
europepmc   +1 more source

Inhibition of Enterovirus A71 by Selenium Nanoparticles Interferes with JNK Signaling Pathways

, 2019
Yinghua Li, Tiantian Xu, Zhengfang Lin, Changbing Wang, Yu Xia, Min Guo, Mingqi Zhao, Yi Chen, Bing Zhu   +8 more
openalex   +1 more source

Wu-tou decoction attenuates neuropathic pain via suppressing spinal astrocytic IL-1R1/TRAF6/JNK signaling [PDF]

, 2017
Chao Wang, Xiangying Kong, Chunyan Zhu, Chunfang Liu, Danni Sun, Qionghong Xu, Zhiyun Mao, Qingxia Qin, Hongchang Su, Dan‐Qiao Wang, Xiaoliang Zhao, Na Lin   +11 more
openalex   +1 more source

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Attack of the kinases: JNK signaling in metabolism. [PDF]

Am J Physiol Regul Integr Comp Physiol
Fernández-González I, Vattathara JJ, Davis RJ, Sabio G, López M.   +4 more
europepmc   +1 more source