Results 221 to 230 of about 262,074 (332)

Polyhexamethylene guanidine phosphate induces IL-6 and TNF-α expression through JNK-dependent pathway in human lung epithelial cells

, 2018
Min‐Seok Kim, Jin-Young Han, Sunghwan Kim, Hyung Young Kim, Doin Jeon, Kyuhong Lee   +5 more
openalex   +2 more sources

Deep learning‐based H&E‐derived risk scores in colorectal cancer: associations with tumour morphology, biology, and predicted drug response

The Journal of Pathology, EarlyView.
Abstract Over recent years, several deep learning (DL) models have been presented to predict colorectal cancer (CRC) patient survival directly from haematoxylin and eosin (H&E)‐stained routine whole‐slide images (WSIs). Unlike traditional studies that rely on manually defined histopathological features, weakly supervised DL allows training directly on ...
Nic G Reitsam, Xiaofeng Jiang, Junhao Liang, Bianca Grosser, Veselin Grozdanov, Chiara ML Loeffler, Marco Gustav, Tim Lenz, Hannah S Muti, Zunamys I Carrero, Nicholas P West, Philip Quirke, Sebastian Foersch, Moritz Jesinghaus, Wolfram Müller, Tanwei Yuan, Michael Hoffmeister, Hermann Brenner, Jitendra Jonnagaddala, Nicholas J Hawkins, Robyn L Ward, Heike I Grabsch, Bruno Märkl, Jakob N Kather   +23 more
wiley   +1 more source

FAK/SRC-JNK axis promotes ferroptosis via upregulating ACSL4 expression. [PDF]

Cell Death Dis
Qin J, Ma S, Wang J, Huang S, Luan J, He J, Hou G, Sun N, Zhang W, Gao M.   +9 more
europepmc   +1 more source

What practicing pathologists and oncologists should know about the new computational pathology‐based companion diagnostic tools

The Journal of Pathology, EarlyView.
Abstract The integration of artificial intelligence into pathology is transforming the assessment of histological and immunohistochemical (IHC) slides, offering opportunities to reduce variability and streamline diagnostics. In practical terms, most available tools and research models emulate the diagnostic capabilities of pathologists by detecting ...
Diana Montezuma, Sara P. Oliveira, Inti Zlobec, Nadieh Khalili, Jordi Temprana‐Salvador, Sabine Leh, David Ameisen, Mircea‐Sebastian Șerbănescu, Arsela Prelaj, Jakob Nikolas Kather, Norman Zerbe, Vincenzo L'Imperio   +11 more
wiley   +1 more source

Molecular and cellular effects of the combined treatment with Camptothecin and Roscovitine in human lung and colon adenocarcinoma cells [PDF]

, 2008
De Mattia, Roberta
core   +1 more source

Gomisin A ameliorates metastatic melanoma by inhibiting AMPK and ERK/JNK-mediated cell survival and metastatic phenotypes

, 2019
Yo-Han Han, Jeong-Geon Mun, Hee Dong Jeon, Jin Bong Park, Ji-Ye Kee, Seung‐Heon Hong   +5 more
openalex   +1 more source

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

ASCT2 palmitoylation regulated by JNK1-ZDHHC14 axis orchestrates glutamine metabolism and NSCLC progression. [PDF]

Cell Discov
Chen X, Ke Z, Wei S, Chen J, Zhu K, Xu J, Zhao Y, Cen M, Jin Y, Pan Z, Xiong J, Chen Y, Dong C, Cao Q, Cao C.   +14 more
europepmc   +1 more source

Prevalence of non‐alcoholic fatty liver disease and its association with different combinations of weight status and metabolic abnormalities in children aged 6–18 years

Pediatric Investigation, EarlyView.
Children with non‐overweight combined with metabolic risk factors might increase the risk of non‐alcoholic fatty liver disease (NAFLD). These findings suggest that overweight and obesity should not be the sole criterion for NAFLD screening in children. In particular, more attention should be given to non‐overweight combined with metabolic abnormalities
Peiyu Ye, Luting Peng, Liwang Gao, Xiaonan Li, Qin Liu, Pei Xiao, Liang Wang, Xiaoyan Shi, Jun Ma, Yanhui Dong, Dongling Dai, Qinghua Yang, Xinchun Chen, Xin Fan, Naijun Wan, Jin Zhang, Bin Li, Lin Zhou, Guangsheng Wu, Lin Yang, Yan He, Yinkun Yan, Jie Mi   +22 more
wiley   +1 more source

Transcription-dependent and -independent functions of Drosophila p53 isoforms in the induction of apoptosis and senescence-associated tumorigenesis. [PDF]

Cell Death Dis
Pérez-Aguilera M, Ruiz-Losada M, Gil Cortes P, Benchaib M, Rubio C, Baena-López LA, Baonza A, Estella C.   +7 more
europepmc   +1 more source