Results 61 to 70 of about 262,074 (332)

CtBP impedes JNK- and Upd/STAT-driven cell fate misspecifications in regenerating Drosophila imaginal discs. [PDF]

, 2018
Regeneration following tissue damage often necessitates a mechanism for cellular re-programming, so that surviving cells can give rise to all cell types originally found in the damaged tissue. This process, if unchecked, can also generate cell types that
Alexander, Larissa, HARIHARAN, Iswar Krishna, Worley, Melanie   +2 more
core   +2 more sources

JNK Regulation of Oncogenesis

Molecules and Cells, 2006
The literature provides strong precedent for both pro-tumorigenic and tumor suppressor roles for the c-Jun N-terminal kinases (JNKs) in the setting of oncogenesis. Clearly, JNKs are activated by numerous oncogenes and growth factors and the literature documents a role for these MAP kinases in cell proliferation and transformation.
Lynn E, Heasley, Sun-Young, Han
openaire   +2 more sources

CR3 and Dectin-1 Collaborate in Macrophage Cytokine Response through Association on Lipid Rafts and Activation of Syk-JNK-AP-1 Pathway [PDF]

, 2015
Copyright: © 2015 Huang et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source ...
Brown, Gordon D, Chen, Wen-Yu, Chu, Ching-Liang, Chuu, Chih-Pin, Huang, Juin-Hua, Lin, Ching-Yu, Wu, Sheng-Yang, Wu-Hsieh, Betty A   +7 more
core   +7 more sources

Network Motifs in JNK Signaling [PDF]

Genes & Cancer, 2013
Multiple growth factors and extracellular signals can lead to activation of the c-Jun amino N-terminal protein kinase (JNK) pathway. Activation of JNK can in turn lead to a multitude of downstream changes in phosphorylation and transcriptional activation within the cell. Mapping the upstream and downstream connectivity within the JNK network reveals an
Vasudha, Sehgal, Prahlad T, Ram
openaire   +2 more sources

Half-Spin Tautological Relations and Faber's Proportionalities of Kappa Classes [PDF]

, 2019
We employ the $1/2$-spin tautological relations to provide a particular combinatorial identity. We show that this identity is a statement equivalent to Faber's formula for proportionalities of kappa-classes on $\mathcal{M}_g$, $g\geq 2$.
Garcia-Failde, Elba, Kramer, Reinier, Lewański, Danilo, Shadrin, Sergey   +3 more
core   +3 more sources

Human tribbles-1 controls proliferation and chemotaxis of smooth muscle cells via MAPK signaling pathways [PDF]

, 2007
Migration and proliferation of smooth muscle cells are key to a number of physiological and pathological processes, including wound healing and the narrowing of the vessel wall.Previous work has shown links between inflammatory stimuli and vascular ...
Agnes Czibula, Andrea R. King, Anthony G. Wilson, Bonventre, Che, Choukroun, David C. Crossman, Du, Emily Heath, Endre Kiss-Toth, Force, Goldschmidt, Grosshans, Hegedus, Hegedus, Hongtao Guan, Hye Youn Sung, Iynedjian, Jones, Ju, Katalin Eder, King, Kiss-Toth, Kiss-Toth, Kiss-Toth, Koo, Lai, Levchenko, Li, Majesky, Mata, McCarthy, Michnick, Mii, Morton, Ohoka, Remy, Remy, Robinson, S. Kim Suvarna, Saka, Sato, Satterthwaite, Schwarzer, Seher, Sheila E. Francis, Stary, Stary, Stary, Steven K. Dower, Surapisitchat, Takeishi, Touyz, Warner, Wilkin, Xia, Yamakawa, Yang, Yue   +58 more
core   +1 more source

Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells

Molecular Oncology, EarlyView.
We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller, Susanne Ebner, Carmen Haselrieder, Julia K. Günther, Astrid Drasche, Sophie Strich, Chiara Volani, Andrea Medici, Aleksandar Nikolajevic, Alex Deltedesco, Johannes E. Sigmund, Michael J. Blumer, Martin Hermann, Johanna Vanacker, Gerald Brandacher, Eduard Stefan, Omar Torres‐Quesada, Jakob Troppmair   +17 more
wiley   +1 more source

Effect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease [Retraction]

International Journal of COPD, 2023
Liu CY, Wu JH, Chen ZY, et al. Int J Chron Obstruct Pulmon Dis. 2021;16:2375–2383. The Editor and Publisher of International Journal of Chronic Obstructive Pulmonary Disease are retracting the published article.
Liu CY, Wu JH, Chen ZY, Zhang Y, Huang CL, Lin AM, Xu XT, Gao XH   +7 more
doaj  

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

CO₂ Sorption and Regeneration Properties of K₂CO₃/Al₂O₃-Based Sorbent at High Pressure and Moderate Temperature

Applied Sciences, 2022
In this study, the CO2 sorption mechanisms and regeneration properties of alumina-based sorbent using K2CO3 loading under high-pressure and moderate temperature conditions were examined.
Do-Yeong Ryu, Seongbin Jo, Tae-Young Kim, Soo-Yeong In, Jin-Hyeok Woo, Jong-Heon Lee, Ho-Jin Chae, Jae-Kuk Kim, Jae-Eun Hwang, Jae-Chang Kim, Soo-Chool Lee   +10 more
doaj   +1 more source