Results 61 to 70 of about 297,973 (327)

Chlorogenic Acid Attenuates Dextran Sodium Sulfate-Induced Ulcerative Colitis in Mice through MAPK/ERK/JNK Pathway

BioMed Research International, 2019
Objective Observe the protective effect of chlorogenic acid on dextran sulfate-induced ulcerative colitis in mice and explore the regulation of MAPK/ERK/JNK signaling pathway.
Wenyan Gao, Chang-hong Wang, Li Yu, Tianjiao Sheng, Zhuolin Wu, Xiaoqian Wang, Dongqi Zhang, Yi-fan Lin, Yang Gong   +8 more
semanticscholar   +1 more source

Network Motifs in JNK Signaling [PDF]

Genes & Cancer, 2013
Multiple growth factors and extracellular signals can lead to activation of the c-Jun amino N-terminal protein kinase (JNK) pathway. Activation of JNK can in turn lead to a multitude of downstream changes in phosphorylation and transcriptional activation within the cell. Mapping the upstream and downstream connectivity within the JNK network reveals an
Vasudha, Sehgal, Prahlad T, Ram
openaire   +2 more sources

Axonal stress kinase activation and tau misbehavior induced by kinesin-1 transport defects [PDF]

, 2009
Many neurodegenerative diseases exhibit axonal pathology, transport defects, and aberrant phosphorylation and aggregation of the microtubule binding protein tau. While mutant tau protein in frontotemporal dementia and parkinsonism linked to chromosome 17
Falzone, Tomas Luis, Goldstein, Lawrence S. B., Lillo, Concepción, Rodrigues, Elizabeth M., Stokin, Gorazd B., Westerman, Eileen L., Williams, David S.   +6 more
core   +1 more source

Bim and Bmf synergize to induce apoptosis in Neisseria gonorrhoeae infection [PDF]

, 2009
: Bcl-2 family proteins including the pro-apoptotic BH3-only proteins are central regulators of apoptotic cell death. Here we show by a focused siRNA miniscreen that the synergistic action of the BH3-only proteins Bim and Bmf is required for apoptosis ...
A Cuconati, A Gross, A Muller, A Zychlinsky, AG Letai, B Antonsson, C Dehio, CR Hauck, DR Green, E Oda, EM Kupsch, FJ Bauer, G Kroemer, Guido Kroemer, H Kim, H Puthalakath, H Puthalakath, H. Steven Seifert, HL Howie, IM Mosleh, J Zha, JB Bliska, K Lei, K Nakano, K Rajalingam, K Rajalingam, K Wang, Kathleen Gottschalk, Krishnaraj Rajalingam, L Chen, M Naumann, M Naumann, M Naumann, MA Apicella, MC Wei, N Machuy, N Tajeddine, Nikolaus Machuy, O Billker, O Kepp, Oliver Kepp, P Massari, P Muenzner, P Muenzner, PF Cartron, S Cory, S Makino, SE McCaw, SM Frisch, SN Willis, T Kuwana, T Rudel, T Schmelzle, Thomas Rudel, Volker Brinkmann, Yuri Churin, Z Xia   +56 more
core   +9 more sources

Understanding signaling cascades in melanoma [PDF]

, 2008
Understanding regulatory pathways involved in melanoma development and progression has advanced significantly in recent years. It is now appreciated that melanoma is the result of complex changes in multiple signaling pathways that affect growth control,
Akslen L. A., Berger A. J., Berking C., Bhoumik A., Bhoumik A., Chen X., Claffey K. P., Collisson E. A., Coppock D. L., Dahia P. L. M., Dhawan P., Dorsky R. I., Ehebauer M., Eisenmann K. M., Genersch E., Goding C. R., Goodall J., Gorden A., Guldberg P., Gurzov E. N., Herbst R. A., Hingorani S. R., Hughes M. J., Huguier S., Iozzo R. V., Jonsson M., Jorgensen K., Karin M., Kennedy N. J., Kumar R., Lacal P. M., Li N., Maeno K., Meyskens F. L., Miller J. R., Miyazono K., Niu G., Okuyama R., Omholt K., Park B. K., Piek E., Qin J.-Z., Rangaswami H., Rimm D. L., Rofstad E. K., Satyamoorthy K., Soldatencov V. A., Stewart F. A., Tago K.-i., Thomson J. A., Tokita T., Tsai E. Y., Tsao H., van Elsas A., Wu M., Yang J., Yang J., Yang Y. M., Zhou X. P.   +58 more
core   +1 more source

The Role of the Dysregulated JNK Signaling Pathway in the Pathogenesis of Human Diseases and Its Potential Therapeutic Strategies: A Comprehensive Review

Biomolecules
JNK is named after c-Jun N-terminal kinase, as it is responsible for phosphorylating c-Jun. As a member of the mitogen-activated protein kinase (MAPK) family, JNK is also known as stress-activated kinase (SAPK) because it can be activated by ...
Huaying Yan, Lan-fang He, De Lv, Jun Yang, Zhu Yuan   +4 more
semanticscholar   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Effect of Doxofylline on Reducing the Inflammatory Response in Mechanically Ventilated Rats with Chronic Obstructive Pulmonary Disease [Retraction]

International Journal of COPD, 2023
Liu CY, Wu JH, Chen ZY, et al. Int J Chron Obstruct Pulmon Dis. 2021;16:2375–2383. The Editor and Publisher of International Journal of Chronic Obstructive Pulmonary Disease are retracting the published article.
Liu CY, Wu JH, Chen ZY, Zhang Y, Huang CL, Lin AM, Xu XT, Gao XH   +7 more
doaj  

Cop1 constitutively regulates c-Jun protein stability and functions as a tumor suppressor in mice [PDF]

, 2011
Biochemical studies have suggested conflicting roles for the E3 ubiquitin ligase constitutive photomorphogenesis protein 1 (Cop 1; also known as Rfwd2) in tumorigenesis, providing evidence for both the oncoprotein c-Jun and the tumor suppressor p53 as ...
Aleksandra Zwolinska, Angel, Baert, Bannister, Chang, Chen, Danovi, de Launoit, Dentin, Derijard, Dieter Defever, Domenico Migliorini, Dornan, Edwards, Eferl, Enrico Radaelli, Fuchs, Geertrui Denecker, Horn, Jean-Christophe Marine, Karin, Kato, Kominami, Krummel, Kyriakis, Lopez-Bergami, Mariani, Marine, Mendrysa, Morse HC, Nakayama, Ouyang, Qi, Rajesh Vyas, Ramaswamy, Rincon, Rossant, Schreiber, Sven Bogaerts, Tino Hochepied, Vanessa Depaepe, Wang, William C. Skarnes, Zhong   +43 more
core   +2 more sources

Activation of AMPK inhibits inflammatory response during hypoxia and reoxygenation through modulating JNK-mediated NF-κB pathway.

Metabolism: Clinical and Experimental, 2018
BACKGROUND AMP-activated Protein Kinase (AMPK) is a stress-activated kinase that protects against cardiomyocyte injury during ischemia and reperfusion.
Xu Chen, Xuan Li, Wenyan Zhang, Jie He, Bo Xu, Bowen Lei, Zhenhua Wang, Courtney A. Cates, Thomas V. Rousselle, Ji Li   +9 more
semanticscholar   +1 more source