Phosphorylation of an RNA‐Binding Protein Rck/Me31b by Hippo Is Essential for Adipose Tissue Aging
Aging Cell, EarlyView.Evolutionary conserved Hippo/Mst1 signaling non‐canonically regulates the stability of mRNAs through directly phosphorylating a subset of RNA binding proteins to stabilize lipolytic mRNAs. Hpo pathway contributes to the regulation of Drosophila lifespan by modulating the expression and activity of Me31b/RCK, which subsequently affects mRNA levels of ...
Eunbyul Yeom +26 more
wiley +1 more source
EFFECT OF SOMAN ON JNK AND P38 MITOGEN ACTIVATED PROTEIN KINASE (MAPK) PATHWAYS [PDF]
Military Medical Science Letters, 2012 Jaroslav Pejchal +8 more
openaire +1 more source
The FASEB Journal, 2014 Mitogen activated protein kinases (MAPKs) play an important role in cell grow, proliferation and apoptosis in the heart. The MAPK family involves three major subgroups including extracellular signal‐regulated protein kinase (ERK1/2), p38, and c‐jun N‐terminal kinases (JNK). Despite many studies demonstrating anti‐hypetrophic action of AMP‐kinase (AMPK),
Giselle Barreto +3 more
openaire +2 more sources
Mechanistic Insights Into 5′‐tiRNA‐His‐GTG Mediated Activation of the JNK Pathway in Skin Photoaging
Aging Cell, EarlyView.5′‐tiRNA‐His‐GTG expression level is upregulated in the photoaging cell model. 5′‐tiRNA‐His‐GTG negatively regulates the expression of NUP98, thereby activating the JNK signaling pathway to regulate cell senescence. ABSTRACT UV exposure leads to skin damage, thus inducing skin aging.
Lihao Liu +10 more
wiley +1 more source
The molecular landscape of AL amyloidosis
British Journal of Haematology, EarlyView.Within the bone marrow, the clonal plasma cell population exhibits an abnormal expression of non‐coding RNAs, which, in turn, upregulates anti‐apoptotic genes (BCL2, MCL1, BCL2L1), leading to an anti‐apoptotic effect that promotes plasma cell survival.
Tal Zvida‐Bloch +4 more
wiley +1 more source
A Monte Carlo study of ligand-dependent integrin signal initiation [PDF]
arXiv, 2010 Integrins are allosteric cell adhesion receptors that control many important processes, including cell migration, proliferation, and apoptosis. Ligand binding activates integrins by stabilizing an integrin conformation with separated cytoplasmic tails, thus enabling the binding of proteins that mediate cytoplasmic signaling.
arxiv
Targeting Regulation of Macrophage to Treat Metabolic Disease: Role of Phytochemicals
Cell Proliferation, EarlyView.One‐third of the world's population is affected by metabolic syndrome. Complicated pathogenesis and limited drugs cause the growing prevalence of metabolic syndrome. Macrophage‐mediated metaflammation is closely associated with the development of metabolic syndrome. The role of phytochemicals targeting macrophages in the treatment of metabolic syndrome
Zeting Ye +6 more
wiley +1 more source
Peptides targeting the mitogen-activated protein kinase pathway (JNK/Jun) fail to reduce infarct volume after permanent MCAO in Sprague Dawley rats [PDF]
, 2012 Cindy Si +6 more
openalex +2 more sources
MAPK Signaling Pathways in Hepatic Ischemia/Reperfusion Injury
Journal of Inflammation Research, 2023 Bo Yu,* Yalong Zhang,* Tianyu Wang, Jiayu Guo, Chenyang Kong, Zhongbao Chen, Xiaoxiong Ma, Tao Qiu Department of Organ Transplantation, Renmin Hospital of Wuhan University, Wuhan, Hubei Province, People’s Republic of China*These authors ...
Yu B +7 more
doaj
Type II tumour necrosis factor-α receptor (TNFR2) activates c-Jun N-terminal kinase (JNK) but not mitogen-activated protein kinase (MAPK) or p38 MAPK pathways [PDF]
, 2001 Orla J. Jupp +7 more
openalex +1 more source