Results 201 to 210 of about 161,447 (312)

Manipulation of the Unfolded Protein Response by Intracellular Bacterial Pathogens: Mechanisms of ER Hijacking and Therapeutic Implications

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
This review illustrates how intracellular bacterial pathogens—such as Brucella, Mycobacterium tuberculosis, and Legionella—secrete effector proteins that specifically target the IRE1α, PERK, and ATF6 branches of the unfolded protein response (UPR) to hijack ER stress signaling.
Enhui Dai, Dongjie Sun, Yanxiao Zhao, Mengtao Zhang, Yifan Wu, Jiabo Ding   +5 more
wiley   +1 more source

Targeting the MAPK Pathway in Cancer. [PDF]

Int J Mol Sci
Kadasah SF.
europepmc   +1 more source

Biochemical and Physiological Effects of Galanin in Health and Disease

The FASEB Journal, Volume 40, Issue 2, 31 January 2026.
Galanin is a biologically active neuropeptide hormone that mediates its effects through three galanin receptors. Galanin signaling induces changes in glucose homeostasis amongst others and plays a dynamic role in the physiological health of many organ systems.
Patrick Mireles, Yubo Wang, Kathryn Rhodes, Sharon DeMorrow   +3 more
wiley   +1 more source

Dissecting stress-activated protein kinase (SAPK)-signaling pathways using multiplex gene knockout HeLa cells. [PDF]

J Biol Chem
Ito C, Yamamoto M, Yokota N, Nakamura N, Shiomi M, Kizu M, Ichinose M, Fujii S, Fujii T, Fukunaga R.   +9 more
europepmc   +1 more source

Effect of silver nanoparticles on mitogen-activated protein kinases activation: role of reactive oxygen species and implication in DNA damage.

Mutagenesis, 2015
A. Rinna, Z. Magdolénová, A. Hudecova, M. Kruszewski, M. Refsnes, M. Dusinska   +5 more
semanticscholar   +1 more source

Dexamethasone regulates gene expression in chondrocytes through MKP-1 and downregulates cholesterol hydroxylases CH25H and CYP7B1. [PDF]

Inflamm Res
Lehtola T, Pemmari A, Nummenmaa E, Valjus I, Hämäläinen M, Moilanen T, Vuolteenaho K, Moilanen E.   +7 more
europepmc   +1 more source

<i>Cornus controversa</i> Leaf and Stem Extract Attenuates LPS-Induced Inflammatory Responses in RAW 264.7 Macrophages via NF-κB/MAPK Inhibition and AMPK Activation. [PDF]

J Microbiol Biotechnol
Choi SY, Shin MS, Son HJ, Kim SB, Song P, Lee KM.   +5 more
europepmc   +1 more source

Actions of Rho family small G proteins and p21-activated protein kinases on mitogen-activated protein kinase family members

Molecular and Cellular Biology, 1996
J. Frost, Shuichan Xu, M. Hutchison, S. Marcus, M. Cobb   +4 more
semanticscholar   +1 more source

<i>CSRNP1</i> Promotes Apoptosis and Mitochondrial Dysfunction via ROS-Mediated JNK/p38 MAPK Pathway Activation in Hepatocellular Carcinoma. [PDF]

Oncol Res
Shi H, Chen L, Huang J, Lin X, Huang L, Tang M, Lu K, Wang W, Zhu M.   +8 more
europepmc   +1 more source

Pharmacological Inhibition of JNK Signalling Exerts Anti-Neoplastic Effects on SH-SY5Y Human Neuroblastoma Cells. [PDF]

Int J Mol Sci
Granek Z, Siwecka N, Saramowicz K, Galita G, Golberg M, Majsterek I, Rozpędek-Kamińska W.   +6 more
europepmc   +1 more source