Results 61 to 70 of about 167,044 (343)
BMC Neuroscience, 2013 Background The inactivation of c-Jun N-terminal kinase (JNK) is associated with anti-apoptotic and anti-inflammatory effects in cerebral ischemia, which can be induced by an imbalance between upstream phosphatases and kinases.
Zhu JianXi +7 more
doaj +1 more source
Role of JNK signaling in oral cancer: A mini review
Tumor Biology, 2017 JNKs (c-Jun N-terminal kinases) belong to mitogen-activated protein kinases’ family and become activated by several growth factors, stress, radiation, and other extracellular signals.
Ioannis Gkouveris, Nikolaos G Nikitakis
doaj +1 more source
Atrial Natriuretic Peptide Induces Mitogen-Activated Protein Kinase Phosphatase-1 in Human Endothelial Cells via Rac1 and NAD(P)H Oxidase/Nox2-Activation [PDF]
, 2005 The cardiovascular hormone atrial natriuretic peptide (ANP) exerts anti-inflammatory effects on tumor necrosis factor-α–activated endothelial cells by inducing mitogen-activated protein kinase (MAPK) phosphatase-1 (MKP-1).
Brueckl, Corinna +7 more
core +1 more source
Advance in Reversible Covalent Kinase Inhibitors [PDF]
arXiv, 2021 Reversible covalent kinase inhibitors (RCKIs) are a class of novel kinase inhibitors attracting increasing attention because they simultaneously show the selectivity of covalent kinase inhibitors, yet avoid permanent protein-modification-induced adverse effects.
arxiv
Positional information readout in $Ca^{2+}$ signaling [PDF]
Phys. Rev. Lett. 123, 058102 (2019), 2017 Living cells respond to spatial signals. Signal transmission to the cell interior often involves the release of second messengers like $Ca^{2+}$ . They will eventually trigger a physiological response by activating kinases that in turn activate target proteins through phosphorylation. Here, we investigate theoretically how positional information can be
arxiv +1 more source
Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology
International Journal of Molecular Sciences, 2018 Bone undergoes continuous remodeling, which is homeostatically regulated by concerted communication between bone-forming osteoblasts and bone-degrading osteoclasts.
Kyunghee Lee +3 more
semanticscholar +1 more source
Membrane glucocorticoid receptors are localised in the extracellular matrix and signal through the MAPK pathway in mammalian skeletal muscle fibres [PDF]
, 2015 A number of studies have previously proposed the existence of glucocorticoid receptors on the plasma membrane of many cell types including skeletal muscle fibres.
Dietmar Steverding +8 more
core +1 more source
Functions of Bifans in Context of Multiple Regulatory Motifs in Signaling Networks [PDF]
, 2007 Representation of intracellular signaling networks as directed graphs allows for the identification of regulatory motifs. Regulatory motifs are groups of nodes with the same connectivity structure, capable of processing information. The bifan motif, made of two source nodes directly cross-regulating two target nodes, is an over-represented motif in a ...
arxiv +1 more source
Asthmatic airway smooth muscle CXCL10 production: mitogen-activated protein kinase JNK involvement
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2012 CXCL10 (IP10) is involved in mast cell migration to airway smooth muscle (ASM) bundles in asthma. We aimed to investigate the role of cytokine-induced MAPK activation in CXCL10 production by ASM cells from people with and without asthma. Confluent growth-arrested ASM cells were treated with inhibitors of the MAPKs ERK, p38, and JNK and transcription ...
Christopher E. Brightling +11 more
openaire +5 more sources