Results 71 to 80 of about 333,292 (305)

Relational Contracts and Job Design [PDF]

open access: yes
This paper analyzes the problem of optimal job design when there is only one contractible and imperfect performance measure for all tasks whose contribution to firm value is non-veritable.
Anja Schöttner
core  

Image and Reality: the Case of Job Satisfaction [PDF]

open access: yes, 2006
This study makes a distinction between two types of utility. Experienced utility is defined as the job satisfaction derived from the present job, estimated by using a subjective evaluation of job satisfaction.
Theodossiou, Ioannis   +2 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

Impact of work design on psychological work reactions and job performance among technical workers: A longitudinal study in Malaysia

open access: yes, 2010
Work design has long been found to affect employee well-being, but scholars have begun to question whether the established theoretical relations regarding work design continue to hold given the enormous changes in the nature of work during the past two ...
Panatik, Siti Aisyah
core  

The Swedish Contribution to Job Quality

open access: yes, 2022
What is distinctive about the Swedish contribution to progressive worklife reform, and what does it contribute to the current job quality literature?
Hampson, Ian, Sandberg, Åke
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

open access: yesMolecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim   +3 more
wiley   +1 more source

Changing work engagement: The longitudinal effect of a job redesign intervention among public sector employees [PDF]

open access: yesStrategic Management, 2017
Work or employee engagement might be increased through job re-design interventions such as top-down managerial interventions, bottom-up job crafting or bipolar ideals.
Hernaus Tomislav   +2 more
doaj  

Organisational climate and its effect on job engagement: exploring the mediating effect of employees level of job satisfaction

open access: yes, 2013
This study examined two under-researched organisational climate facets, integration and family-focused supervisor support, as predictors of employees' job engagement.
Koch, Timothy C
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

open access: yesMolecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq   +8 more
wiley   +1 more source

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