Results 101 to 110 of about 9,292,676 (297)

The Performance of Portuguese Job-centers

Ekonomiaz. Revista vasca de Economía, 2018
This paper analyzes the performance of the country-wide system of 86 job-centers in Portugal, which have the public mandate of matching unemployed individuals with vacancies. The paper uses a rich micro dataset for the years 1998-2002 which allows the construction of individual unemployment duration spells and subsequent employment outcomes, while ...
Dario Sciulli, Antonio Gomes de Menezes
openaire   +3 more sources

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

PERFORMANCE BASED PAY AS A DETERMINANT OF JOB SATISFACTION: A STUDY IN MALAYSIA GIATMARA CENTERS [PDF]

Compensation management literature highlights that performance based pay has two major characteristics: participation in pay systems and adequacy of pay.
Nurzawani ZAKARIA, Mohd Hamran MOHAMAD, Nurhana M RAFIUDDIN, Aniza WAMIN, Azman ISMAIL, Norashikin Sahol HAMID   +5 more
core  

Regulation of the lncRNA NEAT1 by p53‐ΔNp63 crosstalk modulates the DNA damage response and therapeutic efficacy in HNSCC

Molecular Oncology, EarlyView.
In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico, Veronica La Banca, Silvia D'Amico, Stefano Scalera, Sara Nicolai, Angelo Peschiaroli   +5 more
wiley   +1 more source

JOB-monitor 2012-2016

, 2017
De JOB-monitor is in 2001 door Jongeren Organisatie Beroepsonderwijs (JOB) opgezet om de tevredenheid van mbo-studenten te meten. Elke twee jaar laat JOB de monitor uitvoeren door onderzoeksbureau ResearchNed.
Brukx, D.A.P., Bendig-Jacobs, J., Jongeren Organisatie Beroepsonderwijs - JOB, Wartenbergh-Cras, F.P.   +3 more
core   +2 more sources

Job Satisfaction and Job Performance Among Critical Care Nurses: The Moderating Role of Work Engagement in Public Hospitals

Risk Management and Healthcare Policy
Ola Naiem Al-Fuqaha,1 Ahmad Rayan,1 Manal Hassan Baqeas,2,3 Wafaa Tawfiq Alqadrie,4 Fadwa Alhalaiqa,5 Abdul-Monim Batiha,6 Ahmad M Rayani7 1Faculty of Nursing, Zarqa University, Zarqa, Jordan; 2School of Nursing, La Trobe University, Bundoora, Australia;
Al-Fuqaha ON, Rayan A, Baqeas MH, Alqadrie WT, Alhalaiqa F, Batiha AM, Rayani AM   +6 more
doaj  

Paclitaxel induces NM2‐dependent cellular contraction through GEF‐H1 dissociation from microtubules and RhoA/ROCK activation in cancer cells

Molecular Oncology, EarlyView.
Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez, Rafael Pérez‐Díaz, Hugo Ramos‐Solano, Marina Garrido‐Casado, Vanessa C. Talayero, Miguel Vicente‐Manzanares   +5 more
wiley   +1 more source