Results 71 to 80 of about 2,216,539 (356)

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source

The factor analysis of organizational commitment, job satisfaction and performance among lecturers in Batam [PDF]

, 2019
This article intended to determine the important elements in commitment, satisfaction and job performance of university lecturers. This study involved 179 respondents from 3 universities located in Batam, Indonesia.
Hazriyanto, Hazriyanto, Ibrahim, Badaruddin   +1 more
core   +2 more sources

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The Effect of Social Media Use on Job Performance: Exploring the Role of Technostress, Social Capital, and Job Satisfaction as Mediators [PDF]

Journal of Systems Thinking in Practice
The primary objective of this study is to examine the relationship between social media use and job performance, with a specific focus on exploring the mediating roles of technostress, social capital, and job satisfaction.
Alireza Amini, Leyla Hatami, Mohammad Taghi Abbasi Shavazi   +2 more
doaj   +1 more source

Job Monitoring in an Interactive Grid Analysis Environment [PDF]

, 2004
The grid is emerging as a great computational resource but its dynamic behavior makes the Grid environment unpredictable. Systems and networks can fail, and the introduction of more users can result in resource starvation.
Ali, Arshad, Anjum, Ashiq, Bunn, Julian, Cavanaugh, Richard, McClatchey, Richard, Newman, Harvey, Steenberg, Conrad, Thomas, Michael, ur Rehman, Wahas, van Lingen, Frank, Willers, Ian   +10 more
core   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function

FEBS Open Bio, EarlyView.
We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke, Michal Banasik, Rokas Juodeikis, Martin J. Warren, Richard W. Pickersgill   +4 more
wiley   +1 more source

Pengaruh Pelatihan dan Karakteristik Pekerjaan Terhadap Prestasi Kerja Perawat di Badan Pelayanan Kesehatan Rumah Sakit Umum Daerah Langsa

Jurnal Manajemen dan Wirausaha, 2010
Job performance for a nurse is very important. One effort to improve job performance is by following training and develop the job characteristics. Langsa DistrictGeneral Hospital has striven to enhance the job performance for the nurses through training ...
Prihatin Lumbanraja, Cut Nizma
doaj  

Automating Fault Tolerance in High-Performance Computational Biological Jobs Using Multi-Agent Approaches [PDF]

, 2014
Background: Large-scale biological jobs on high-performance computing systems require manual intervention if one or more computing cores on which they execute fail.
Alexandrov, Vassil, McKee, Gerard, Varghese, Blesson   +2 more
core   +3 more sources