Results 71 to 80 of about 12,767,435 (355)

Examining the Relationship Between Job Burnout and Job Performance in Emergency Medical Technicians of Esfarayen Faculty of Medical Sciences [PDF]

Beyhagh
Background and Aims: Emergency medical workers are the first to experience stressful situations, and these stresses in the long term lead to job burnout, which may overshadow their performance.
Sara AbediKooshki
doaj  

Role ambiguity and job performance of employees in the service sector SMEs in Malaysia [PDF]

, 2011
Small and medium size enterprises (SMEs) play a crucial role in the economic development of Malaysia, of which the majority are in the service sector.Employees of the service sector SMEs have often been associated with low level of job performance and ...
June Hamy Beris, L.A. Sethela, Mahmood, Rosli   +1 more
core  

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Investigating the Organizational and Psychological Factors Affecting the Development and Improvement of Faculty Members\' Job Performance

Rāhburdhā-yi Mudīriyyat dar Niẓām-i Salāmat, 2017
Background: Knowing factors affecting the creation and development of faculty members' job performance is very useful for educational, research and therapeutic activities.
Abbas Sabet, Hossein Yadolahi Khales, Saeed Razeghi, Mohammad Hossein Shakarizadeh Shirazi   +3 more
doaj  

Positive affect and job performance in psychiatric nurses: A moderated mediation analysis

Nursing Open, 2023
Aims The aims of this research were (a) to determine if job satisfaction plays an intermediary role between positive affect and job performance; (b) to explore whether the mediating process of positive affect affecting job performance through job ...
Xiucheng Ma, Dongmei Wu, Xiaofeng Hou
doaj   +1 more source

Job-demand for Learning and Job-related Learning: the Mediating Effect of Job Performance Improvement Initiatives

, 2007
This study examined whether job-performance-improvementinitiatives mediate the relationship between individuals’ job-demand for learning and job-related learning. Data were obtained from 115 full-time employees in a diverse range of occupations.
Bartram, Timothy, Bartram, T, Loon, Mark, Loon, M, Loon, Mark Kong Chew, Bartram, T.   +5 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Is Job Performance Affected By Job Motivation and Job Satisfaction?

KnE Social Sciences, 2018
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A Eliyana, D Sawitri, H Bramantyo
openaire   +2 more sources

Epigenetic heterogeneity and plasticity in therapy‐induced tumor states through single‐cell multi‐omics

Molecular Oncology, EarlyView.
Single‐cell multi‐omics reveals epigenetic heterogeneity across therapy‐adaptive tumor states, including quiescent/dormant, drug‐tolerant persister, and EMT‐like phenotypes. By linking regulatory features with state‐associated biomarkers, these approaches inform biomarker‐guided therapeutic strategies for evolving tumors.
Hee Jung Kim, Hwiyeong Lee, Jin Hong, Daechan Park   +3 more
wiley   +1 more source

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

FEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn, Barbara Seroka, Ryszard Lazny, Zenon Lotowski, Thore Rohwerder   +4 more
wiley   +1 more source