Results 51 to 60 of about 1,561,827 (296)
pH‐mediated activation of the lysosomal arginine sensor SLC38A9
FEBS Letters, EarlyView.Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley +1 more source
International Journal of Adolescence and YouthThis study explored the mediating role of job search self-efficacy on the relationship between perceived employability and job search behaviour of unemployed youths in Ethiopia by using a mixed-methods approach.
Yohannes Bisa Biramo +3 more
doaj +1 more source
Evaluation of effects of program for improving skills and motivation for employment [PDF]
Psihologija, 2011 Contemporary programs that have been implemented in order to help unemployed reduce time for finding a job are based on clear theoretical background and empirical evidence.
Marić Zorica +1 more
doaj +1 more source
Risks, 2023 Unemployment insurance provides temporary cash benefits to eligible unemployed workers. Benefits are sometimes extended by discretion during economic slumps.
Rich Ryan
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Frontiers in Psychology, 2020 Job search is associated with various obstacles and difficulties that can elicit negative emotions and undermine positive emotions. Having self-compassion may benefit job seekers’ well-being by stimulating more balanced emotional responses to negative ...
Loes M. Kreemers +3 more
doaj +1 more source
Frontiers in Sociology, 2022 The employment psychology of young migrant workers in China has changed drastically in past decades. In particular, the construction industry has been facing labor shortages and aging workforces for years, and the eruption of coronavirus disease 2019 has
Cong Xue +3 more
doaj +1 more source
Why human connection is the true metric of research success
FEBS Open Bio, EarlyView.Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan +3 more
wiley +1 more source