Results 1 to 10 of about 20,657 (229)
The BET inhibitor JQ1 targets fat metabolism and counteracts obesity
Journal of Advanced ResearchIntroduction: Obesity, one of the most frequent health problems in the adult population, is a condition characterized by excessive white adipose tissue accumulation and accompanied by the increased risk to develop other disorders such as type II diabetes,
Claudia Fornelli +7 more
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Cells, 2023 (+)-JQ1, a specific chemical inhibitor of bromodomain and extraterminal (BET) family protein 4 (BRD4), has been reported to inhibit smooth muscle cell (SMC) proliferation and mouse neointima formation via BRD4 regulation and modulate endothelial nitric ...
Binjie Yan +9 more
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The BRD4 inhibitor JQ1 suppresses tumor growth by reducing c-Myc expression in endometrial cancer
Journal of Translational Medicine, 2022 Background Endometrial cancer (EC) is the most common gynecological malignancy in developed countries. Efficacy of the bromodomain 4 (BRD4) inhibitor JQ1 has been reported for the treatment of various human cancers, but its potential impact on EC remains
Yingxin Pang +9 more
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Effects of BRD4 inhibitor JQ1 on the expression profile of super-enhancer related lncRNAs and mRNAs in cervical cancer HeLa cells [PDF]
PeerJObjective To investigate the effects of bromine domain protein 4 (BRD4) inhibitor JQ1 on the expression profile of super-enhancer-related lncRNAs (SE-lncRNAs) and mRNAs in cervical cancer (CC) HeLa-cells. Methods The CCK8 method was implemented to detect
Jianqing Zheng +3 more
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Synergistic anti-proliferative activity of JQ1 and GSK2801 in triple-negative breast cancer
BMC Cancer, 2022 Background Triple-negative breast cancer (TNBC) constitutes 10–20% of breast cancers and is challenging to treat due to a lack of effective targeted therapies. Previous studies in TNBC cell lines showed in vitro growth inhibition when JQ1 or GSK2801 were
Nanda Kumar Yellapu +6 more
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Antioxidants, 2023 Peritoneal dialysis (PD) is a current replacement therapy for end-stage kidney diseases (ESKDs). However, long-term exposure to PD fluids may lead to damage of the peritoneal membrane (PM) through mechanisms involving the activation of the inflammatory ...
Vanessa Marchant +13 more
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JQ1 as a BRD4 Inhibitor Blocks Inflammatory Pyroptosis-Related Acute Colon Injury Induced by LPS
Frontiers in Immunology, 2021 Endotoxemia is a severe inflammation response induced by infection especially bacterial endotoxin translocation, which severely increases mortality in combination with acute colon injury.
Ling Chen +11 more
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Cells, 2022 Anti-programmed death 1 (PD-1) is a revolutionary treatment for many cancers. The response to anti-PD-1 relies on several properties of tumor and immune cells, including the expression of PD-L1 and PD-1.
Delphine Sauvage +7 more
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(+)-JQ1 Upregulates SIRT3 to Suppress cGAS/STING Pathway-Mediated Neuronal Inflammation and Ferroptosis After Hypoxic-Ischemic Encephalopathy [PDF]
Drug Design, Development and TherapyQianqian Yu,1,2,* Jiahao Ou,1,2,* Yuqi Luo,1,2,* Ming Shen,1,2 Jia Lou,3 Saizhi Jiang,4,5 Lizi Lin,5 Shutian Zhang,5 Jianghu Zhu,1,2 Zhenlang Lin,1,2 Mingchu Fang1,2 1Department of Neonatology, The Second Affiliated Hospital and ...
Yu Q +10 more
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BRD4 inhibition suppresses histone H4 UFMylation to increase ferroptosis sensitivity through TXNIP [PDF]
Cell Death and DiseaseBromodomain Containing 4 (BRD4) inhibition selectively alters gene transcription, which subsequently influences cellular responses to BET inhibitors.
Zhen Yang +10 more
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