Results 21 to 30 of about 20,657 (229)
Cell Death and Differentiation, 2022 Atrophic (“dry”) form of age-related macular degeneration (AMD) is a leading cause of vision loss characterized by macular retinal pigment epithelium (RPE) and the ensuing photoreceptor degeneration.
M. Zou +12 more
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BET Inhibitor JQ1 Blocks Inflammation and Bone Destruction [PDF]
Journal of Dental Research, 2014 BET proteins are a group of epigenetic regulators controlling transcription through reading acetylated histone tails and recruiting transcription complexes. They are considered as potential therapeutic targets in many distinct diseases. A novel synthetic bromodomain and extraterminal domain (BET) inhibitor, JQ1, was proved to suppress oncogene ...
S, Meng +10 more
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Journal of experimental & clinical cancer research : CR, 2023 Background Advanced gastric cancer (GC) is a lethal malignancy, harboring recurrent alterations in cell cycle pathway, especially the CDKN2A-CDK4/CDK6/CCND1 axis.
Mei Feng +3 more
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Bromodomain inhibitor JQ1 reversibly blocks IFN-γ production [PDF]
Scientific Reports, 2019 AbstractAs a class, ‘BET’ inhibitors disrupt binding of bromodomain and extra-terminal motif (BET) proteins, BRD2, BRD3, BRD4 and BRDT, to acetylated histones preventing recruitment of RNA polymerase 2 to enhancers and promoters, especially super-enhancers, to inhibit gene transcription.
Gibbons, Hunter R. +5 more
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The BET Inhibitor JQ1 Potentiates the Anticlonogenic Effect of Radiation in Pancreatic Cancer Cells
Frontiers in Oncology, 2022 We reported previously that the BET inhibitor (BETi) JQ1 decreases levels of the DNA repair protein RAD51 and that this decrease is concomitant with increased levels of DNA damage.
Patrick L. Garcia +8 more
doaj +1 more source
Scientific Reports, 2021 Microglia, resident macrophages of the brain that act as primary immune cells, play essential roles in innate immunity and neuroinflammatory pathologies.
Mina Baek +7 more
doaj +1 more source
Respiratory Research, 2023 Background Pulmonary arterial hypertension (PAH) encompasses a group of diseases characterized by raised pulmonary vascular resistance, resulting from vascular remodelling and inflammation.
S. Mumby +9 more
semanticscholar +1 more source
Metformin and JQ1 synergistically inhibit obesity-activated thyroid cancer [PDF]
Endocrine-Related Cancer, 2018 Compelling epidemiological evidence shows a strong positive correlation of obesity with thyroid cancer.In vivostudies have provided molecular evidence that high-fat-diet-induced obesity promotes thyroid cancer progression by aberrantly activating leptin-JAK2-STAT3 signaling in a mouse model of thyroid cancer (ThrbPV/PVPten+/−mice).
Sunmi, Park +3 more
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Oncogenesis, 2021 Targeting the epigenome to modulate gene expression programs driving cancer development has emerged as an exciting avenue for therapeutic intervention.
Jack Calder +4 more
doaj +1 more source
Cell Reports, 2020 Summary: JQ1 is a BET-bromodomain inhibitor that has immunomodulatory effects. However, the precise molecular mechanism that JQ1 targets to elicit changes in antibody production is not understood. Our results show that JQ1 induces apoptosis, reduces cell
Isabella Y. Kong +18 more
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