Results 91 to 100 of about 1,352 (181)
Investigating the role of neutrophil extracellular traps in the pathogenesis of juvenile-onset systemic Lupus Erythematosus (JSLE) [PDF]
Background: JSLE is a multisystem autoimmune disorder characterised by the production of autoantibodies against nuclear self-antigens. Activated neutrophils may undergo cell death by NETosis, forming NETs comprising of DNA.
Makuloluwa, Kanchani
core +1 more source
Revista Brasileira de Reumatologia, 2012 OBJETIVOS: Determinar a frequência de anticorpos contra componentes da cromatina no lúpus eritematoso sistêmico juvenil (LESJ) e correlacionar a presença desses autoanticorpos com manifestações clínicas e atividade da doença.
Silene Peres Keusseyan +5 more
doaj +1 more source
Juvenile Systemic Lupus Erythematosus (JSLE): A Literature Review
Medical & Clinical Case Reports JournalJuvenile systemic lupus erythematosus (JSLE) is a rare but clinically impactful autoimmune disease characterized by multisystem inflammation driven by dysregulated autoantibody production. Compared to adult-onset lupus, JSLE follows a more aggressive course, with earlier onset, severe visceral involvement and greater cumulative organ damage.
Sarila Hali Kloster Lopes +13 more
openaire +1 more source
A case of Juvenile Systemic Lupus Erythematosus in a pre-pubertal child with atopic eczema
Journal of the Pakistan Medical AssociationJuvenile Systemic Lupus Erythematosus (JSLE) is a subset of SLE, with onset before eighteen years of age and associated with increased mortality and morbidity. JSLE is a complex autoimmune disease with respect to its underlying genetics.
Ghazal Afzal +2 more
doaj +1 more source
Serum cystatin C and βeta-2 microglobulin as potential biomarkers in children with lupus nephritis
The Turkish Journal of Gastroenterology, 2023 Objectives: In this study, we aimed to assess serum levels of Cystatin C (Cys C) and beta-2 microglobulin (β2M) in juvenile systemic lupus erythematosus (JSLE) patients and to investigate their role as potential biomarkers of lupus nephritis (LN) and ...
Eman Baraka +3 more
doaj
Dysregulation of complement factor H in juvenile-onset systemic lupus erythematosus patients
The Turkish Journal of Gastroenterology, 2022 Objectives: This study aims to evaluate the expression pattern of factor H in peripheral blood and the frequency of factor H autoantibodies in plasma of juvenile-onset systemic lupus erythematosus (jSLE) patients compared to healthy controls ...
Eman Eissa +3 more
doaj
Evaluation of bone health problems among a group of children with rheumatological diseases
Egyptian Pediatric Association GazetteBackground Bone health problems such as decreased bone mineral density (BMD), osteopenia, and osteoporosis are major concerns during childhood as this period is the most critical for the development of optimum bone mass which is an essential determinant ...
Hala Lotfy +3 more
doaj +1 more source
, 2018 Supplemental material for The effectiveness and safety of biological therapeutics in juvenile-onset systemic lupus erythematosus (JSLE): a systematic review by E Peterknecht, M P Keasey and M W Beresford in ...
E Peterknecht (5876006) +2 more
core +1 more source
Brazilian Journal of Medical and Biological Research, 2007 We assessed the risk factors associated with death in patients hospitalized for juvenile systemic lupus erythematosus (JSLE) and evaluated the autopsy reports.
M.M.M. Faco +5 more
doaj
Scientific ReportsWhile adaptive immune responses have been studied extensively in SLE (systemic lupus erythematosus), there is limited and contradictory evidence regarding the contribution of natural killer (NK) cells to disease pathogenesis.
Anna Radziszewska +7 more
doaj +1 more source