Results 71 to 80 of about 732 (166)

Serum cystatin C and βeta-2 microglobulin as potential biomarkers in children with lupus nephritis

The Turkish Journal of Gastroenterology, 2023
Objectives: In this study, we aimed to assess serum levels of Cystatin C (Cys C) and beta-2 microglobulin (β2M) in juvenile systemic lupus erythematosus (JSLE) patients and to investigate their role as potential biomarkers of lupus nephritis (LN) and ...
Eman Baraka, Nashwa Hashaad, Walid Abdelhalim, Gehan Elolemy   +3 more
doaj  

Dysregulation of complement factor H in juvenile-onset systemic lupus erythematosus patients

The Turkish Journal of Gastroenterology, 2022
Objectives: This study aims to evaluate the expression pattern of factor H in peripheral blood and the frequency of factor H autoantibodies in plasma of juvenile-onset systemic lupus erythematosus (jSLE) patients compared to healthy controls ...
Eman Eissa, Botros Morcos, Dalia Dorgham, Naglaa Kholoussi   +3 more
doaj  

JSLE and the NLRP3 inflammasome – a novel therapeutic target [PDF]

, 2017
Introduction: Juvenile-onset Systemic Lupus Erythematosus (JSLE) is a severe autoimmune disease causing organ damage and long-term morbidity. Impaired clearance of nuclear debris from cells and upregulated circulating damage-associated molecular patterns (DAMPs) and cytokines are thought to trigger cell death and thus, further increase release of pro ...
openaire  

Investigating phagocytic markers in Juvenile-onset Systemic Lupus Erythematosus (JSLE) monocytes and macrophages [PDF]

, 2013
Background Juvenile-onset systemic lupus erythematosus (JSLE) is a chronic, severe, multi-systemic autoimmune disease. Impaired phagocytic function has been implicated as an initial step in the pathogenesis of this disease, in relation to the clearance of cells undergoing apoptosis. The apoptotic process has been shown to be dysregulated in neutrophils,
openaire   +1 more source

Comment on: Limited sensitivity and specificity of the ACR/EULAR-2019 classification criteria for SLE in JSLE?—observations from the UK JSLE Cohort Study

Rheumatology, 2021
Adriana R, Fonseca, Flavio, Sztajnbok, Marta, Rodrigues, Sheila Knupp, Oliveira, Marcelo G P, Land   +4 more
openaire   +2 more sources

Evaluation of bone health problems among a group of children with rheumatological diseases

Egyptian Pediatric Association Gazette
Background Bone health problems such as decreased bone mineral density (BMD), osteopenia, and osteoporosis are major concerns during childhood as this period is the most critical for the development of optimum bone mass which is an essential determinant ...
Hala Lotfy, Somaia Mostafa, Hadeel Mohamed Seif, Hend Mohamed Abu Shady   +3 more
doaj   +1 more source

Risk factors associated with the death of patients hospitalized for juvenile systemic lupus erythematosus

Brazilian Journal of Medical and Biological Research, 2007
We assessed the risk factors associated with death in patients hospitalized for juvenile systemic lupus erythematosus (JSLE) and evaluated the autopsy reports.
M.M.M. Faco, C. Leone, L.M.A. Campos, M.V. Febrônio, H.H.S. Marques, C.A. Silva   +5 more
doaj  

Active juvenile systemic lupus erythematosus is associated with distinct NK cell transcriptional and phenotypic alterations

Scientific Reports
While adaptive immune responses have been studied extensively in SLE (systemic lupus erythematosus), there is limited and contradictory evidence regarding the contribution of natural killer (NK) cells to disease pathogenesis.
Anna Radziszewska, Hannah Peckham, Nina M. de Gruijter, Restuadi Restuadi, Wing Han Wu, Elizabeth C. Jury, Elizabeth C. Rosser, Coziana Ciurtin   +7 more
doaj   +1 more source

Characterizing juvenile-onset systemic lupus erythematosus: clinical outcomes, disease progression, and determinants in pediatric populations [PDF]

ARP Rheumatology
Introduction: This study aims to delineate the sociodemographic, clinical, and laboratory characteristics of juvenile-onset systemic lupus erythematosus (jSLE) patients.
Gülcan Ozomay Baykal, Betül Sözeri
doaj  

Are Selenium Status and Inflammation Linked to Cardiometabolic Risk Factors in Inborn Errors of Immunity? [PDF]

Nutrients
Rossi RGT, Pereira L, Suano-Souza FI, Andrade IGA, Prado RD, Aranda CS, Previdelli AN, Sarni ROS, Terreri MT.   +8 more
europepmc   +1 more source