Results 71 to 80 of about 1,352 (181)

Lymphocyte apoptosis and its association with the inflammatory markers and disease severity in juvenile-onset systemic lupus erythematosus patients

Pediatric Rheumatology Online Journal
Background The defective clearance of apoptotic bodies in juvenile-onset systemic lupus erythematosus (jSLE) potentially leads to the persistence of autoreactive lymphocytes and the perpetuation of the autoimmune response. These factors contribute to the
Eman Eissa, Rania Kandil, Dalia Dorgham, Raghda Ghorab, Naglaa Kholoussi   +4 more
doaj   +1 more source

Antibodies against endogenous retroviruses

Immunological Reviews, Volume 328, Issue 1, Page 300-313, November 2024.
Summary The human genome harbors hundreds of thousands of integrations of ancient retroviruses, amassed over millions of years of evolution. To reduce further amplification in the genome, the host prevents transcription of these now endogenous retroviruses (ERVs) through epigenetic repression and, with evolutionary time, ERVs are incapacitated by ...
Mihaela Chisca, Jean‐David Larouche, Qi Xing, George Kassiotis   +3 more
wiley   +1 more source

Juvenile systemic lupus erythematosus presenting as pancarditis

Pediatric Rheumatology Online Journal, 2019
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with marked variation in its clinical presentation. Juvenile SLE (jSLE) accounts for 15–20% of all cases and is diagnosed when SLE manifests before 18 years of age. Pancarditis
D. O’Leary, C. O’Connor, L. Nertney, E. J. MacDermott, D. Mullane, O. Franklin, O. G. Killeen   +6 more
doaj   +1 more source

Biomarkers for systemic lupus erythematosus: A scoping review

Immunity, Inflammation and Disease, Volume 12, Issue 10, October 2024.
Abstract Background In recent years, newly discovered potential biomarkers have great research potential in the diagnosis, disease activity prediction, and treatment of systemic lupus erythematosus (SLE). Objective In this study, a scoping review of potential biomarkers for SLE over several years has identified the extent to which studies on biomarkers
Su‐jie Zhang, Rui‐yang Xu, Long‐li Kang   +2 more
wiley   +1 more source

Lymphocyte subset distribution during longitudinal follow-up in JSLE patients, stratified into treatment-naïve and treated groups.

, 2022
(A) Percentages of lymphocyte subsets in 34 JSLE patients during active disease and follow-up until inactive disease (treatment-naïve patients = 15, treated patients = 19), (B) Disease activity measured by SLEDAI-2K during active disease and follow-up ...
Butsabong Lerkvaleekul (12055191), Kanchana Tangnararatchakit (4856476), Soamarat Vilaiyuk (10027924), Nopporn Apiwattanakul (7298975), Nisa Jirapattananon (12055194), Supanart Srisala (7432034)   +5 more
core   +1 more source

Correlation of single nucleotide polymorphisms in the AGT gene with susceptibility to systemic lupus erythematosus in Northeast China

International Journal of Immunogenetics, Volume 51, Issue 2, Page 81-88, April 2024.
Abstract To investigate the correlation between susceptibility to systemic lupus erythematosus (SLE) and single nucleotide polymorphisms (SNPs) rs699, rs4762 and rs1926723 in the AGT gene in the population of Northeast China, while also introducing a new method for early detection of SLE.
Huitao Wu, Xuan Zhang, Guiling Lin, Qi Zhang, Ziman He, Zhe Wang, Wenlu Xu, Xiyu Yin, Linglan Su, Yanping Zhuang, Aimin Gong   +10 more
wiley   +1 more source

Modern treatment options for systemic lupus erythematosus in children (literature review)

Современная ревматология
The treatment of juvenile-onset systemic lupus erythematosus (jSLE) is a complex task in view of the diversity of clinical manifestations and the course of the disease as well as the high risk of organ damage.
M. I. Kaleda, I. P. Nikishina
doaj   +1 more source

Atherosclerosis Progression in the APPLE Trial Can Be Predicted in Young People With Juvenile‐Onset Systemic Lupus Erythematosus Using a Novel Lipid Metabolomic Signature

Arthritis &Rheumatology, Volume 76, Issue 3, Page 455-468, March 2024.
Objective Patients with juvenile‐onset systemic lupus erythematosus (JSLE) have increased atherosclerosis risk. This study investigated novel atherosclerosis progression biomarkers in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, the largest investigator‐led randomized control trial of atorvastatin versus placebo for ...
Junjie Peng, Pierre Dönnes, Stacy P. Ardoin, Laura E. Schanberg, Laura Lewandowski, on behalf of APPLE trial investigators and Childhood Rheumatology Research Alliance (CARRA), Stacy Ardoin, Esi Morgan Dewitt, C. Egla Rabinovich, Janet Ellis, Kelly Mieszkalski, Janet Wootton, Peter Chira, Joyce Hsu, Tzielan Lee, Christy Sandborg, Jan Perea, Beth Gottlieb, Patricia Irigoyen, Jennifer Luftig, Shaz Siddiqi, Zhen Ni, Marilynn Orlando, Eileen Pagano, Andrew Eichenfield, Lisa Imundo, Deborah Levy, Philip Kahn, Candido Batres, Digna Cabral, Kathleen A. Haines, Yukiko Kimura, Suzanne C. Li, Jennifer Weiss, Mary Ellen Riordan, Beena Vaidya, Emily von Scheven, Michelle Mietus‐Snyder, Earl Silverman, Lawrence Ng, Suzanne Bowyer, Susan Ballinger, Thomas Klausmeier, Debra Hinchman, Andrea Hudgins, Marilynn Punaro, Shirley Henry, Shuzen Zhang, Nora G. Singer, Elizabeth B. Brooks, Stacy Miner, Nancy Szabo, Lisabeth Scalzi, David Sherry, Libby Dorfeld, Sarajane Wilson, Jenna Tress, Deborah McCurdy, Tatiana Hernandez, Jyotsna Vitale, Marisa Klein‐Gitelman, Angela Kress, Nicole Lowe, Falguni Patel, Carol Wallace, Stephanie Hamilton, Richard Silver, Katie Caldwell, Diane Kamen, Linda Wagner‐Weiner, Becky Puplava, Atanas Lonchev, Gloria Higgins, Monica Bacani, Hermine Brunner, Cynthia Rutherford, Jamie Meyers‐Eaton, Shannen Nelson, Alexei Grom, Larry Jung, Teresa Conway, Lacey Frank, Lori Kuss, Jenny Soep, Hazel Senz, Ann Reed, Thomas Mason, Jane Jaquith, Diana E. Paepke‐Tollefsrud, George Robinson, Elizabeth C. Jury, Coziana Ciurtin   +91 more
wiley   +1 more source

Severe Juvenile-Onset Systemic Lupus Erythematosus: A Case Series-Based Review and Update

Children, 2023
Juvenile-onset systemic lupus erythematosus (jSLE) is a multisystemic disease diagnosed in young patients based on the clinical criteria of the European League Against Rheumatism (EULAR) and the American College of Rheumatology (ACR).
Sergi Huerta-Calpe, Ignacio Del Castillo-Velilla, Aida Felipe-Villalobos, Iolanda Jordan, Lluïsa Hernández-Platero   +4 more
doaj   +1 more source

Increased Fas and Bcl-2 Expression on Peripheral Blood T and B Lymphocytes from Juvenile-Onset Systemic Lupus Erythematosus, but not from Juvenile Rheumatoid Arthritis and Juvenile Dermatomyositis

Clinical and Developmental Immunology, 2006
Defective regulation of apoptosis may play a role in the development of autoimmune diseases. Fas and Bcl-2 proteins are involved in the control of apoptosis.
Bernadete L. Liphaus, Maria H. B. Kiss, Solange Carrasco, Claudia Goldenstein-Schainberg   +3 more
doaj   +1 more source