Results 51 to 60 of about 732 (166)

Juvenile systemic lupus erythematosus presenting as pancarditis

Pediatric Rheumatology Online Journal, 2019
Background Systemic lupus erythematosus (SLE) is a chronic autoimmune disease with marked variation in its clinical presentation. Juvenile SLE (jSLE) accounts for 15–20% of all cases and is diagnosed when SLE manifests before 18 years of age. Pancarditis
D. O’Leary, C. O’Connor, L. Nertney, E. J. MacDermott, D. Mullane, O. Franklin, O. G. Killeen   +6 more
doaj   +1 more source

Biomarkers for systemic lupus erythematosus: A scoping review

Immunity, Inflammation and Disease, Volume 12, Issue 10, October 2024.
Abstract Background In recent years, newly discovered potential biomarkers have great research potential in the diagnosis, disease activity prediction, and treatment of systemic lupus erythematosus (SLE). Objective In this study, a scoping review of potential biomarkers for SLE over several years has identified the extent to which studies on biomarkers
Su‐jie Zhang, Rui‐yang Xu, Long‐li Kang   +2 more
wiley   +1 more source

Increased Fas and Bcl-2 Expression on Peripheral Blood T and B Lymphocytes from Juvenile-Onset Systemic Lupus Erythematosus, but not from Juvenile Rheumatoid Arthritis and Juvenile Dermatomyositis

Clinical and Developmental Immunology, 2006
Defective regulation of apoptosis may play a role in the development of autoimmune diseases. Fas and Bcl-2 proteins are involved in the control of apoptosis.
Bernadete L. Liphaus, Maria H. B. Kiss, Solange Carrasco, Claudia Goldenstein-Schainberg   +3 more
doaj   +1 more source

Correlation of single nucleotide polymorphisms in the AGT gene with susceptibility to systemic lupus erythematosus in Northeast China

International Journal of Immunogenetics, Volume 51, Issue 2, Page 81-88, April 2024.
Abstract To investigate the correlation between susceptibility to systemic lupus erythematosus (SLE) and single nucleotide polymorphisms (SNPs) rs699, rs4762 and rs1926723 in the AGT gene in the population of Northeast China, while also introducing a new method for early detection of SLE.
Huitao Wu, Xuan Zhang, Guiling Lin, Qi Zhang, Ziman He, Zhe Wang, Wenlu Xu, Xiyu Yin, Linglan Su, Yanping Zhuang, Aimin Gong   +10 more
wiley   +1 more source

Modern treatment options for systemic lupus erythematosus in children (literature review)

Современная ревматология
The treatment of juvenile-onset systemic lupus erythematosus (jSLE) is a complex task in view of the diversity of clinical manifestations and the course of the disease as well as the high risk of organ damage.
M. I. Kaleda, I. P. Nikishina
doaj   +1 more source

Association of TNFAIP3 (rs10499194) and TNF-α (rs1800629) gene polymorphisms with susceptibility to systemic lupus erythematosus with juvenile onset and its clinical phenotypes in the Russian pediatric population

Современная ревматология, 2023
Numerous recent studies have shown that TNFAIP3 and TNF-α gene polymorphisms are associated with susceptibility to certain autoimmune and inflammatory diseases, including systemic lupus erythematosus (SLE), systemic scleroderma, rheumatoid arthritis ...
M. Yu. Krylov, M. I. Kaleda, E. Yu. Samarkina   +2 more
doaj   +1 more source

Atherosclerosis Progression in the APPLE Trial Can Be Predicted in Young People With Juvenile‐Onset Systemic Lupus Erythematosus Using a Novel Lipid Metabolomic Signature

Arthritis &Rheumatology, Volume 76, Issue 3, Page 455-468, March 2024.
Objective Patients with juvenile‐onset systemic lupus erythematosus (JSLE) have increased atherosclerosis risk. This study investigated novel atherosclerosis progression biomarkers in the Atherosclerosis Prevention in Pediatric Lupus Erythematosus (APPLE) trial, the largest investigator‐led randomized control trial of atorvastatin versus placebo for ...
Junjie Peng, Pierre Dönnes, Stacy P. Ardoin, Laura E. Schanberg, Laura Lewandowski, on behalf of APPLE trial investigators and Childhood Rheumatology Research Alliance (CARRA), Stacy Ardoin, Esi Morgan Dewitt, C. Egla Rabinovich, Janet Ellis, Kelly Mieszkalski, Janet Wootton, Peter Chira, Joyce Hsu, Tzielan Lee, Christy Sandborg, Jan Perea, Beth Gottlieb, Patricia Irigoyen, Jennifer Luftig, Shaz Siddiqi, Zhen Ni, Marilynn Orlando, Eileen Pagano, Andrew Eichenfield, Lisa Imundo, Deborah Levy, Philip Kahn, Candido Batres, Digna Cabral, Kathleen A. Haines, Yukiko Kimura, Suzanne C. Li, Jennifer Weiss, Mary Ellen Riordan, Beena Vaidya, Emily von Scheven, Michelle Mietus‐Snyder, Earl Silverman, Lawrence Ng, Suzanne Bowyer, Susan Ballinger, Thomas Klausmeier, Debra Hinchman, Andrea Hudgins, Marilynn Punaro, Shirley Henry, Shuzen Zhang, Nora G. Singer, Elizabeth B. Brooks, Stacy Miner, Nancy Szabo, Lisabeth Scalzi, David Sherry, Libby Dorfeld, Sarajane Wilson, Jenna Tress, Deborah McCurdy, Tatiana Hernandez, Jyotsna Vitale, Marisa Klein‐Gitelman, Angela Kress, Nicole Lowe, Falguni Patel, Carol Wallace, Stephanie Hamilton, Richard Silver, Katie Caldwell, Diane Kamen, Linda Wagner‐Weiner, Becky Puplava, Atanas Lonchev, Gloria Higgins, Monica Bacani, Hermine Brunner, Cynthia Rutherford, Jamie Meyers‐Eaton, Shannen Nelson, Alexei Grom, Larry Jung, Teresa Conway, Lacey Frank, Lori Kuss, Jenny Soep, Hazel Senz, Ann Reed, Thomas Mason, Jane Jaquith, Diana E. Paepke‐Tollefsrud, George Robinson, Elizabeth C. Jury, Coziana Ciurtin   +91 more
wiley   +1 more source

Clinical and laboratorial outcome of different age-onset systemic lupus erythematosus patients in Jiangsu, China: a multicentre retrospective study

Scientific Reports, 2022
Studies on clinical features of systemic lupus erythematosus among different age-onset patients are lacking in China. This multicentre study aimed to systemically compare clinical manifestations, comorbidities, organ involvement, and laboratory findings ...
Lihui Wen, Ziyan Chen, Ziyi Jin, Wenyou Pan, Lin Liu, Min Wu, Fuwan Ding, Huaixia Hu, Xiang Ding, Hua Wei, Yaohong Zou, Xian Qian, Meimei Wang, Jian Wu, Juan Tao, Jun Tan, Zhanyun Da, Miaojia Zhang, Jing Li, Xuebing Feng, Jun Liang, Huayong Zhang, Lingyun Sun   +22 more
doaj   +1 more source

Factors affecting bone mineral density in children and adolescents with systemic lupus erythematosus [PDF]

Annals of Pediatric Endocrinology & Metabolism
Purpose Patients with juvenile-onset systemic lupus erythematosus (JSLE) are at a high risk of entering adulthood with disease-related morbidities like reduced bone mass and osteoporosis.
Su Jin Park, Soo Yeun Sim, Dae Chul Jeong, Byung-Kyu Suh, Moon Bae Ahn   +4 more
doaj   +1 more source

Juvenile-onset systemic lupus erythematosus (jSLE) – Pathophysiological concepts and treatment options

Best Practice & Research Clinical Rheumatology, 2017
The systemic autoimmune/inflammatory condition systemic lupus erythematosus (SLE) manifests before the age of 16 years in 10-20% of all cases. Clinical courses are more severe, and organ complications are more common in patients with juvenile SLE. Varying gender distribution in different age groups and increasing severity with younger age and the ...
Hedrich, CM, Smith, EMD, Beresford, MW
openaire   +2 more sources