Results 41 to 50 of about 732 (166)

Hepatitis C virus antibodies in high risk juvenile onset systemic lupus erythematosus

Revista Brasileira de Reumatologia, 2016
Objective To evaluate the prevalence of hepatitis C virus (HCV) infection in high risk juvenile systemic lupus erythematosus (JSLE). Study design Forty low income JSLE patients (6M:34F; mean age 19 ± 4.4 yrs; mean disease duration 6 ± 3.2 yrs) were ...
Nádia E. Aikawa, Ana P. Nascimento, André L.S. Hayata, Eloisa Bonfá, Cláudia Goldenstein-Schainberg   +4 more
doaj   +1 more source

Risk factors for subsequent lupus nephritis in patients with juvenile-onset systemic lupus erythematosus: a retrospective cohort study

Pediatric Rheumatology Online Journal, 2023
Background Lupus nephritis (LN) is a crucial organ involvement in systemic lupus erythematosus (SLE). Patients with LN have higher morbidity and mortality rates than those without.
Tzu-Chuan Hsu, Yao-Hsu Yang, Li-Chieh Wang, Jyh-Hong Lee, Hsin-Hui Yu, Yu-Tsan Lin, Ya-Chiao Hu, Bor-Luen Chiang   +7 more
doaj   +1 more source

Reduced expressions of apoptosis-related proteins TRAIL, Bcl-2, and TNFR1 in NK cells of juvenile-onset systemic lupus erythematosus patients: relations with disease activity, nephritis, and neuropsychiatric involvement

Frontiers in Immunology
BackgroundLupus pathogenesis is mainly ascribed to increased production and/or impaired clearance of dead cell debris. Although self-reactive T and B lymphocytes are critically linked to lupus development, neutrophils, monocytes, and natural killer (NK ...
Bernadete L. Liphaus, Bernadete L. Liphaus, Simone C. Silva, Patrícia Palmeira, Clovis A. Silva, Clovis A. Silva, Claudia Goldenstein-Schainberg, Magda Carneiro-Sampaio   +7 more
doaj   +1 more source

Urinary soluble alpha chain of the interleukin-2 receptor as a biomarker of active lupus nephritis in Egyptian children with juvenile systemic lupus erythematosus

The Turkish Journal of Gastroenterology, 2021
Objectives: This study aims to assess the urinary soluble alpha chain of the interleukin-2 receptor (sCD25) concentrations in patients with juvenile systemic lupus erythematosus (JSLE) and to evaluate its validity to be a possible marker of disease ...
Waleed HASSAN, Eman BEHIRY, Marwa MAHGOUB   +2 more
doaj  

Advancements and Challenges in Salivary Metabolomics for Early Detection and Monitoring of Systemic Diseases

MedComm, Volume 6, Issue 10, October 2025.
Salivary metabolomics offers a noninvasive and effective approach for early disease detection and monitoring. Salivary metabolites reflect systemic metabolism, inflammation, and external factors such as diet and stress. Advance in bioinformatics and machine learning facilitates the identification of metabolic biomarkers with high diagnostic accuracy ...
Xinyuan Zhao, Xu Chen, Zihao Zhou, Jiarong Zheng, Yunfan Lin, Yucheng Zheng, Rongwei Xu, Shen Hu, Li Cui   +8 more
wiley   +1 more source

The Anti‐Lupus Plate: Mapping Nutritional Interventions to Inflammatory Pathways in Systemic Lupus Erythematosus

Food Science &Nutrition, Volume 13, Issue 9, September 2025.
The present article links certain nutritional factors to pathways controlling cytokine equilibrium, oxidative damage, endothelium integrity, and regulatory T cell activity. These elements include unsaturated fats, vitamins, polyphenols, probiotics, and fiber‐derived short‐chain fatty acids (SCFAs).
Xiaowei Zhang, Guoliang Fan
wiley   +1 more source

Different Faces for Different Places: Heterogeneity of Neutrophil Phenotype and Function

Journal of Immunology Research, Volume 2019, Issue 1, 2019., 2019
As the most abundant leukocytes in the circulation, neutrophils are committed to innate and adaptive immune effector function to protect the human body. They are capable of killing intruding microbes through various ways including phagocytosis, release of granules, and formation of extracellular traps.
Peiqing Yang, Yanhong Li, Yan Xie, Yi Liu, Alvaro González   +4 more
wiley   +1 more source

Baricitinib Treatment in RNU7‐1‐Associated Aicardi–Goutières Syndrome in a South African Child: A Case Report

American Journal of Medical Genetics Part A, Volume 197, Issue 5, May 2025.
ABSTRACT Aicardi–Goutières syndrome (AGS) is a rare monogenic type I interferonopathy. Janus kinase (JAK) inhibition has emerged as a potential treatment for AGS. RNU7‐1 is one of the most recently discovered genes for AGS, and the clinical effects of JAK inhibition in these patients have not been reported. Here, we describe the diagnosis and treatment
Timothy F. Spracklen, Shehnaaz Akhalwaya, Sally Ackermann, Carolina Uggenti, Luis Seabra, Yanick J. Crow, Kate Webb   +6 more
wiley   +1 more source

Lymphocyte apoptosis and its association with the inflammatory markers and disease severity in juvenile-onset systemic lupus erythematosus patients

Pediatric Rheumatology Online Journal
Background The defective clearance of apoptotic bodies in juvenile-onset systemic lupus erythematosus (jSLE) potentially leads to the persistence of autoreactive lymphocytes and the perpetuation of the autoimmune response. These factors contribute to the
Eman Eissa, Rania Kandil, Dalia Dorgham, Raghda Ghorab, Naglaa Kholoussi   +4 more
doaj   +1 more source

Antibodies against endogenous retroviruses

Immunological Reviews, Volume 328, Issue 1, Page 300-313, November 2024.
Summary The human genome harbors hundreds of thousands of integrations of ancient retroviruses, amassed over millions of years of evolution. To reduce further amplification in the genome, the host prevents transcription of these now endogenous retroviruses (ERVs) through epigenetic repression and, with evolutionary time, ERVs are incapacitated by ...
Mihaela Chisca, Jean‐David Larouche, Qi Xing, George Kassiotis   +3 more
wiley   +1 more source