Results 31 to 40 of about 732 (166)

What Have We Learnt About the Treatment of Juvenile-Onset Systemic Lupus Erythematous Since Development of the SHARE Recommendations 2012?

Frontiers in Pediatrics, 2022
IntroductionJuvenile-onset systemic lupus erythematous (JSLE) is a rare multisystem autoimmune disorder. In 2012, the Single Hub and Access point for pediatric Rheumatology in Europe (SHARE) initiative developed recommendations for the diagnosis ...
Kathy L. Gallagher, Pallavi Patel, Michael W. Beresford, Michael W. Beresford, Eve Mary Dorothy Smith, Eve Mary Dorothy Smith   +5 more
doaj   +1 more source

P166 Possible new role for HCQ in preventing depression in jSLE? [PDF]

Poster presentations, 2020
Background Hydroxychloroquine (HCQ) is a key immunomodulatory treatment in systemic lupus erythematosus (SLE) with pleiotropic effects. Beyond anti-thrombotic, anti-atherosclerotic and anti-diabetic effects, anti-microbial and anti-cancer are possible roles.
Sara Ganhão, Beatriz Silva, Francisca Aguiar, Mariana Rodrigues, Iva Brito, Margarida Figueiredo-Braga   +5 more
openaire   +1 more source

Role of Chemokine (C–X–C Motif) Ligand 10 (CXCL10) in Renal Diseases

Mediators of Inflammation, Volume 2020, Issue 1, 2020., 2020
Chemokine C–X–C ligand 10 (CXCL10), also known as interferon‐γ‐inducible protein 10 (IP‐10), exerts biological function mainly through binding to its specific receptor, CXCR3. Studies have shown that renal resident mesangial cells, renal tubular epithelial cells, podocytes, endothelial cells, and infiltrating inflammatory cells express CXCL10 and CXCR3
Jie Gao, Lingling Wu, Siyang Wang, Xiangmei Chen, Oleh Andrukhov   +4 more
wiley   +1 more source

Association of STAT4 gene single nucleotide polymorphisms with Iranian juvenile-onset systemic lupus erythematosus patients

The Turkish Journal of Pediatrics, 2017
Juvenile-onset systemic lupus erythematosus (JSLE) is a complex autoimmune disease, characterized by multi-organ involvement. Single nucleotide polymorphisms (SNPs) of signal transducer and activator of transcription 4 (STAT4) gene have been reported to
Arash Salmaninejad, Mahdi Mahmoudi, Saeed Aslani, Shiva Poursani, Vahid Ziaee, Nima Rezaei   +5 more
doaj   +1 more source

CD8+ T-Cells in Juvenile-Onset SLE: From Pathogenesis to Comorbidities

Frontiers in Medicine, 2022
Diagnosis of systemic lupus erythematosus (SLE) in childhood [juvenile-onset (J) SLE], results in a more severe disease phenotype including major organ involvement, increased organ damage, cardiovascular disease risk and mortality compared to adult-onset
Coziana Ciurtin, Coziana Ciurtin, Ines Pineda-Torra, Elizabeth C. Jury, George A. Robinson, George A. Robinson   +5 more
doaj   +1 more source

P3 Is there a relationship between lupus anticoagulant autoantibody and fatigue in jSLE? [PDF]

Poster presentations, 2020
Background Fatigue is a common symptom in systemic lupus erythematosus (SLE) and is associated with poorer quality of life and higher depression scores. Lupus anticoagulant (AcL) refers to a subset of autoantibodies to phospholipids interfering with clotting tests, which major clinical association is thrombosis.
Sara Ganhão, Beatriz Silva, Mariana Rodrigues, Francisca Aguiar, Margarida Figueiredo-Braga, Iva Brito   +5 more
openaire   +1 more source

The Comparison of Nailfold Capillaroscopy between Juvenile Systemic Lupus Erythematosus and Healthy Controls: Correlation with Laboratory and Clinical Parameters

International Journal of Vascular Medicine, Volume 2020, Issue 1, 2020., 2020
Background. Nailfold capillaroscopy is a noninvasive technique to recognize peripheral microangiopathy, which is an important feature in systemic lupus erythematosus (SLE). The aims of the present study were to investigate the prevalence of nailfold capillaroscopy (NFC) changes in juvenile systemic lupus erythematosus (JSLE), find out patterns of these
Seyed-Reza Raeeskarami, Navid Namazi, Raheleh Assari, Seyed-Reza Najafizadeh, Zohreh Hassannejad, Vahid Ziaee, Alberto Caggiati   +6 more
wiley   +1 more source

Safety and immunogenicity of influenza A(H3N2) component vaccine in juvenile systemic lupus erythematosus

Advances in Rheumatology, 2023
Introduction Seasonal influenza A (H3N2) virus is an important cause of morbidity and mortality in the last 50 years in population that is greater than the impact of H1N1.
Nadia Emi Aikawa, Eduardo Ferreira Borba, Verena Andrade Balbi, Adriana Maluf Elias Sallum, Izabel Mantovani Buscatti, Lucia Maria Arruda Campos, Kátia Tomie Kozu, Cristiana Couto Garcia, Artur Silva Vidal Capão, Adriana Coracini Tonacio de Proença, Elaine Pires Leon, Alberto José da Silva Duarte, Marta Heloisa Lopes, Clovis Artur Silva, Eloisa Bonfá   +14 more
doaj   +1 more source

Familial aggregation rate of psoriasis in pediatric rheumatic diseases: A tertiary center cross-sectional study and insights into shared autoimmune pathways

Trends in Pediatrics
Objective: The coexistence of psoriasis and juvenile‑onset systemic lupus erythematosus (jSLE) is rare, and data on familial aggregation of psoriasis across pediatric rheumatic diseases are limited.
Elif Kılıç Könte, Gülesser Eylül Şimşek, Kübra Uçak, Zeynep Torunoğlu, Ece Aslan, Nergis Akay, Ümit Gül, Esma Aslan, Aybüke Günalp, Fatih Haşlak, Mehmet Yıldız, Amra Adroviç, Sezgin Şahin, Kenan Barut, Özgür Kasapçopur   +14 more
doaj   +1 more source

Juvenile and juvenile-onset systemic lupus erythematosus patients: Clinical characteristics, disease activity and damage

Egyptian Pediatric Association Gazette, 2017
Background: The diagnosis of systemic lupus erythematosus (SLE) in children is challenging. The heterogeneous manifestations and disease impact on the child’s growth highlight the importance of timely diagnosis and management.
Rasha E. Gheith, Iman I. El-Gazzar, Hussein S. El Fishawy, Abeer M. Nour El-Din, Dina M.R. Bahgat, Tamer A. Gheita   +5 more
doaj   +1 more source